Download or read book Synthesis of Bicyclo 4 2 0 Octane 7 8 diol for the Verification of a Reported Rearrangement of Cyclooctatetraene written by Elbert C. Herrick and published by . This book was released on 1949 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Part I Studies Concerned with the Synthesis of Octalene and Bicyclo 6 2 0 Deca 1 3 5 7 9 pentaene Part II The Rearrangements of Monosubstituted Cyclo ctatetraenes written by Greg Alan Bullock and published by . This book was released on 1968 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methodologies of Bicyclo 2 2 2 octane Compounds and Progress Toward the Total Synthesis of Parthenolide written by Courtney Arielle Roberts and published by . This book was released on 2016 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Chapter 1, rearrangements of 4-substituted bicyclo[2.2.2]oct-2-enyl-5-selenophenyl esters are explored. Reduction of the esters under radical-generating conditions initially generates a bicyclo[2.2.2]oct-5-en-2-yl radical which can rearrange to a bicyclo[3.2.1]oct-6-en-2-yl radical via a cyclopropylcarbinyl radical. Although the bicyclo[3.2.1]octene system exhibits greater strain than does the bicyclo[2.2.2]octene system, radical-stabilizing substituents can reverse this preference. The product ratios are influenced by the interplay of ring strain and radical stability. In addition, the rearranged products favored the equatorial over the axial isomers, which can be explained by torsional steering. In Chapter 2, different approaches to the synthesis of the optically active bicyclo[2.2.2]octane-2,5-diones are presented. A stereoselective Diels-Alder cycloaddition was explored to construct the bicyclo[2.2.2]octane skeleton in an efficient manner. This approach was hindered by unexpected polymerization and lack of stereoselectivity. A different method of synthesizing the optically active bicyclo[2.2.2]octane-2,5-dione featuring a diastereoselective 1,4-addition is also presented. In Chapter 3, progress toward the total synthesis of parthenolide is described. The synthetic route relies on ring-closing metathesis to close the 10-membered carbocycle of the natural product. The efforts leading up to and including the key ring-closing step are described. Specific attention is given to different methods for overcoming the difficulties associated with medium-sized ring formation.
Download or read book Side Reactions in Organic Synthesis written by Florencio Zaragoza Dörwald and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates
Download or read book Chemistry for Pharmacy Students written by Professor Satyajit D. Sarker and published by John Wiley & Sons. This book was released on 2013-05-28 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student... the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read." –Journal of Chemical Biology, May 2009 Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural products chemistry (in relation to drug molecules). Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy- in relation to drug action and toxicity. Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry. accessible introduction to the key areas of chemistry required for all pharmacy degree courses student-friendly and written at a level suitable for non-chemistry students includes learning objectives at the beginning of each chapter focuses on the physical properties and actions of drug molecules
Download or read book Orbital Interaction Theory of Organic Chemistry written by Arvi Rauk and published by John Wiley & Sons. This book was released on 2004-04-07 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical introduction to orbital interaction theory and its applications in modern organic chemistry Orbital interaction theory is a conceptual construct that lies at the very heart of modern organic chemistry. Comprising a comprehensive set of principles for explaining chemical reactivity, orbital interaction theory originates in a rigorous theory of electronic structure that also provides the basis for the powerful computational models and techniques with which chemists seek to describe and exploit the structures and thermodynamic and kinetic stabilities of molecules. Orbital Interaction Theory of Organic Chemistry, Second Edition introduces students to the fascinating world of organic chemistry at the mechanistic level with a thoroughly self-contained, well-integrated exposition of orbital interaction theory and its applications in modern organic chemistry. Professor Rauk reviews the concepts of symmetry and orbital theory, and explains reactivity in common functional groups and reactive intermediates in terms of orbital interaction theory. Aided by numerous examples and worked problems, he guides readers through basic chemistry concepts, such as acid and base strength, nucleophilicity, electrophilicity, and thermal stability (in terms of orbital interactions), and describes various computational models for describing those interactions. Updated and expanded, this latest edition of Orbital Interaction Theory of Organic Chemistry includes a completely new chapter on organometallics, increased coverage of density functional theory, many new application examples, and worked problems. The text is complemented by an interactive computer program that displays orbitals graphically and is available through a link to a Web site. Orbital Interaction Theory of Organic Chemistry, Second Edition is an excellent text for advanced-level undergraduate and graduate students in organic chemistry. It is also a valuable working resource for professional chemists seeking guidance on interpreting the quantitative data produced by modern computational chemists.
Download or read book The Vocabulary and Concepts of Organic Chemistry written by Milton Orchin and published by John Wiley & Sons. This book was released on 2005-07-08 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a basic reference providing concise, accurate definitions of the key terms and concepts of organic chemistry. Not simply a listing of organic compounds, structures, and nomenclatures, the book is organized into topical chapters in which related terms and concepts appear in close proximity to one another, giving context to the information and helping to make fine distinctions more understandable. Areas covered include: bonding, symmetry, stereochemistry, types of organic compounds, reactions, mechansims, spectroscopy, and photochemistry.
Download or read book Surface Organometallic Chemistry Molecular Approaches to Surface Catalysis written by Jean-Marie Basset and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface organometallic chemistry is a new field bringing together researchers from organometallic, inorganic, and surface chemistry and catalysis. Topics ranging from reaction mechanisms to catalyst preparation are considered from a molecular basis, according to which the "active site" on a catalyst surface has a supra-molecular character. This. the first book on the subject, is the outcome of a NATO Workshop held in Le Rouret. France, in May. 1986. It is our hope that the following chapters and the concluding summary of recommendations for research may help to provide a definition of surface organometallic chemistry. Besides catalysis. the central theme of the Workshop, four main topics are considered: 1) Reactions of organometallics with surfaces of metal oxides, metals. and zeolites; 2) Molecular models of surfaces, metal oxides, and metals; 3) Molecular approaches to the mechanisms of surface reactions; 4) Synthesis and modification of zeolites and related microporous solids. Most surface organometallic chemistry has been carried out on amorphous high-surf ace-area metal oxides such as silica. alumina. magnesia, and titania. The first chapter. contributed by KNOZINGER. gives a short summary of the structure and reactivity of metal oxide surfaces. Most of our understanding of these surfaces is based on acid base and redox chemistry; this chemistry has developed from X-ray and spectroscopic data, and much has been inferred from the structures and reactivities of adsorbed organic probe molecules. There are major opportunities for extending this understanding by use of well-defined (single crystal) oxide surfaces and organometallic probe molecules.
Download or read book Natural Bioactive Products in Sustainable Agriculture written by Joginder Singh and published by Springer Nature. This book was released on 2020-05-11 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses various aspects of bioactive natural products employed in the agrochemical and agriculture sectors. It covers the use of plants, microorganisms, and microbial metabolites as eco-friendly, cost-effective, and sustainable alternatives to chemicals in the field of agriculture. Written by active researchers and academics, the book highlights state-of-art products in the field, as well as the gaps, challenges, and obstacles associated with the use of plants, microbes and their products. Given its scope, it is a valuable resource for the scientific community and professionals in enterprises wanting insights into the latest developments and advances in the context of biological products, including their applications, traditional uses, modern practices, and strategies to harness their full potential.
Download or read book Metathesis Polymerization of Olefins and Polymerization of Alkynes written by Yavuz İmamoğlu and published by Springer Science & Business Media. This book was released on 1998 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from inorganic, organic and polymer chemists, who join forces to report on the state of the art in ring opening metathesis polymerization, acyclic diene metathesis and alkyne polymerization. Topics covered are: mechanism of ROMP reactions, new catalysts for ROMP, new products by ROMP, new catalysts for ADMET, new products by ADMET, degradation of polymers by metathesis reactions, alkyne polymerization and metathesis, and industrial applications of metathesis reactions.
Download or read book Modern Arylation Methods written by Lutz Ackermann and published by John Wiley & Sons. This book was released on 2009-04-22 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, arylation methods are belonging to the most important reaction types in organic synthesis. Lutz Ackermann, a young and ambitious professor has gathered a number of top international authors to present the first comprehensive book on the topic. Starting from a historical review, the book covers hot topics like Palladium-catalyzed arylation of N-H and alpha-C-H-acidic Bonds, Copper-catalyzed arylation of N-H and O-H Bonds, direct arylation reactions, carbanion aromatic synthesis, arylation reactions of alkenes, alkynes and much more. This compact source of high quality information is indispensable to synthetic chemists and those working in the pharmaceutical and chemical industry.
Download or read book Organic Chemistry written by Pierre Vogel and published by John Wiley & Sons. This book was released on 2019-10-07 with total page 1382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the background, tools, and models required to understand organic synthesis and plan chemical reactions more efficiently Knowledge of physical chemistry is essential for achieving successful chemical reactions in organic chemistry. Chemists must be competent in a range of areas to understand organic synthesis. Organic Chemistry provides the methods, models, and tools necessary to fully comprehend organic reactions. Written by two internationally recognized experts in the field, this much-needed textbook fills a gap in current literature on physical organic chemistry. Rigorous yet straightforward chapters first examine chemical equilibria, thermodynamics, reaction rates and mechanisms, and molecular orbital theory, providing readers with a strong foundation in physical organic chemistry. Subsequent chapters demonstrate various reactions involving organic, organometallic, and biochemical reactants and catalysts. Throughout the text, numerous questions and exercises, over 800 in total, help readers strengthen their comprehension of the subject and highlight key points of learning. The companion Organic Chemistry Workbook contains complete references and answers to every question in this text. A much-needed resource for students and working chemists alike, this text: -Presents models that establish if a reaction is possible, estimate how long it will take, and determine its properties -Describes reactions with broad practical value in synthesis and biology, such as C-C-coupling reactions, pericyclic reactions, and catalytic reactions -Enables readers to plan chemical reactions more efficiently -Features clear illustrations, figures, and tables -With a Foreword by Nobel Prize Laureate Robert H. Grubbs Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis is an ideal textbook for students and instructors of chemistry, and a valuable work of reference for organic chemists, physical chemists, and chemical engineers.
Download or read book CRC Handbook of Organic Photochemistry and Photobiology written by Axel G. Griesbeck and published by CRC Press. This book was released on 2012 with total page 943 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title includes research from experts in organic chemistry & many other disciplines. There are sections on new terminology, the usefulness of particular reactions & experimental details.
Download or read book A Textbook Of Organic Chemistry written by Raj K. Bansal and published by New Age International. This book was released on 2007 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers nearly all topics in Organic Chemistry taught upto the B.Sc. level. Topics like resonance, H-bond, hybridization, IUPAC nomenclature, acid-base theory of organic compounds, stereochemistry, structure reactivity relationship and spectroscopy have been introduced early in the book. Subsequent chapters deal with synthetic polymers, aliphatic and aromatic hydrocarbons, alcohols and phenols, ethers, aldehydes, carboxylic acids and their derivatives, amines, carbohydrates, organometallics and terpenes. These topics have been discussed in-depth and in a comprehensive manner. A great deal of attention has been focussed on chemical reactions and their mechanisms. The scope and limitations of the reactions have been stated. Certain topics of general interest namely C.N.G., L.P.G., simple drugs, DNA finger printing, PUFA, trans fatty acids, soaps and detergents, pesticides, industrial alcohols, coal tar, octane number, chromatography, and artificial sweeteners have been highlighted at appropriate places. Also included are approximately 900 in-text and end-of-the-chapter problems, and a set of Multiple Choice Questions (MCQ) at the end of each chapter. A glossary of important terms is also included. This book has been designed as a comprehensive textbook for students upto B.Sc. level. In addition, the book will be immensely useful for those preparing for competitive examinations like I.I.T., AIEEE, medical entrance and others.
Download or read book Eco friendly Synthesis of Fine Chemicals written by Roberto Ballini and published by Royal Society of Chemistry. This book was released on 2009 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: During these early years, the chronic toxicological properties of chemicals were often completely unknown and many unwittingly became indispensable tools of the trade. Early pioneers in green chemistry included Trost (who developed the atom economy principle) and Sheldon (who developed the E-Factor). These measures were introduced to encourage the use of more sustainable chemistry and provide some benchmarking data to encourage scientists to aspire to more benign synthesis. Green chemistry is essentially the design of chemical processes and procedures that reduce or eliminate the use, or the generation, of hazardous substances. Green chemistry is a growing area of research and an increasing number of researchers are now involved in this field. The number of publications has dramatically increased and new recognition of advances made is necessary with respect to other research areas.
Download or read book Principles of Organometallic Chemistry written by G. E. Coates and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Organometallic Compounds (1960) was used not only by specialists but also as an undergraduate textbook. The third edition, recently published in two volumes, is about three times the length of the second and contains considerably more factual material than is appropriate for a student textbook. Therefore we believe that a shorter treatment would be welcome. In planning this book the authors have emphasized matters more of prin ciple than of detail, and have included in the first two chapters some general discussion of the properties and syntheses of organometallic compounds that is not to be found in the larger work. Some aspects of the organic chemistry of arsenic, and of silicon with particular reference to silicone polymers, are also included. Most university teachers of chemistry are becoming seriously concerned about the relentless increase in the amount and complexity of the material that is squeezed into undergraduate chemistry courses. With this in mind the authors have tried to cut detail to a minimum, but readers will find that the relative amount presented varies considerably between the various topics discussed. In general the treatment is more extensive than usual only if either or both of these conditions are met: (1), the subject has significant bearing on other major branches of chemistry including im portant industrial processes; (2), the topic is commonly misunderstood or found to be confusing.
Download or read book Active Oxygen in Chemistry written by Christopher S. Foote and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies.
