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Book Synthesis Characterization and Anticancer Studies of Multinuclear Ruthenium II Arene Complexes Based on a Dendritic Scaffold

Download or read book Synthesis Characterization and Anticancer Studies of Multinuclear Ruthenium II Arene Complexes Based on a Dendritic Scaffold written by Preshendren Govender and published by . This book was released on 2010 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Syntheses Characterization and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands

Download or read book Syntheses Characterization and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands written by Stephen Mensah and published by . This book was released on 2019 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platinum-based drugs have over the years been administered in the treatment of tumours.Unfortunately, platinum resistance and the severe side effects associated with the treatments has necessitated the research for new anti-cancer drugs. Ruthenium(II) and Ruthenium(III) complexes have shown promise as useful alternative anticancer agents. The lead candidates include the Ru(II) complex RAPTA-C, a ruthenium(II)-arene complex [Ru(Îʺ6-p-cymene)Cl2(1,3,5-triaza-7-phosphaadamantane)] and the Ru(III) complex NAMI-A [imidazoleH][trans-Ru(imidazole) (dimethyl sulfoxide)Cl4]. Both compounds have shown potent cytotoxic activity in several primary human tumor models. Unfortunately, NAMI-A could not advance in clinical evaluations due to limited efficacy in vivo, while the clinical evaluation of RAPTA-C is unknown. Therefore, there is a need for novel cancer therapeutics that have high biological activity, are relatively easy to synthesize, and can readily be modified. This work focuses on the use of 2-acetylpyridine and 2-pyridinecarboxaldehyde for the synthesis, characterization, and preliminary evaluation of derivatives of both the RAPTA-C and NAMI-A anticancer complexes containing Schiff base ligands. Here, the results of the synthesis of these compounds and their subsequent characterization using 1H NMR, MS, fluorescence and UV-Vis spectroscopies are presented.

Book Synthesis Nanoparticle Encapsulation and Magnetic Resonance Studies of Metal based Anticancer Complexes

Download or read book Synthesis Nanoparticle Encapsulation and Magnetic Resonance Studies of Metal based Anticancer Complexes written by Gregory MacNeil and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of cisplatin, metal complexes continue to gain interest as anticancer agents. Though a breadth of research has been conducted in this field, many pitfalls and questions remain, such as off-target activity and how exactly metal complexes exhibit their activity. In the search for novel complexes that address these issues, ruthenium and copper have become leading choices. Though a vast array of complexes employing these metals have been reported, their clinical development has often been hindered by low activity and a lack in understanding of their mechanism of action. The work in this thesis looks to address these issues in two ways: (i) by developing novel complexes and methods to breath new life into well-studied metal compounds and (ii) employ magnetic resonance spectroscopies to examine their behaviour in relevant biological environments. Chapter 2 discusses the synthesis of a novel Ru(II)-arene complex appended with a selective estrogen receptor modifier to target breast cancer. These novel complexes were subjected to several different cell assays, including the National Cancer Institute NCI-60 screen, which showed increased activity over the inactive parent ruthenium scaffolds. Chapter 3 presents 19F magnetic resonance imaging methods to develop the theranostic applications of a CF3-appended Keppler-type Ru(III) complex. It is shown that these methods can be used to spatially resolve redox and speciation events in tumour tissues, which is important to understanding their mechanism of action. Chapter 4 presents a robust method to encapsulate these CF3 appended Ru(III) anticancer complexes in polymer nanoparticles to increase their aqueous stability. Cell studies revealed an over 10-fold increase in anticancer activity over the free complexes. Chapter 5 presents and in-depth magnetic resonance study of the aqueous solution behaviour of the copper anticancer complex CasIII-ia. EPR and NMR studies were used to characterize Cu species following dissolution in complex solutions containing HSA, and in the presence of whole cells. Finally, Chapter 6 presents a novel Ru(II)-Ru(III) complex combing the unique biological activities of an organometallic Ru(II) RAPTA-type scaffold and a Ru(III) Keppler-type coordination complex. Cytotoxicity studies of the new dinuclear complex show increased activity relative to mononuclear parent compounds.

Book Synthesis and characterization of hetero multinuclear ruthenium platinum complexes and assessment of their potential as anticancer agents

Download or read book Synthesis and characterization of hetero multinuclear ruthenium platinum complexes and assessment of their potential as anticancer agents written by Isabelle Taylor and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Ruthenium II Polypyridyl Complexes as Potential Anticancer Drugs

Download or read book Ruthenium II Polypyridyl Complexes as Potential Anticancer Drugs written by Yanling Chen and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on biological activities of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anticancer activity both in vitro and in vivo.1−3 The mononuclear RPC, [(phen)2Ru(tatpp)]2+ (MP) and related dinuclear complex [(phen)2Ru(tatpp)Ru(phen)2]4+ (P) have been shown to both intercalate with DNA and shown potentiated DNA cleavage under anaerobic and reducing conditions4−5, as well as shown good selectivity and cytotoxicity towards malignant cell lines in vitro and tumors in vivo.5 Both complexes contain the redox-active tatpp ligand which is thought to be an essential component for the observed biological activities. This thesis is focused on developing improvements to the stereoselective syntheses of the chiral complexes, [delta][delta]-P and [delta]-MP. It is also investigated the synthesis of a new analogue [(phen)2Ru(tadbp)]2+ (B) and its chiral form [delta]-B which contains a modified tatpp ligand that is only capable of binding one Ru ion. Moreover this thesis explores the ability of these large complexes to traverse the cell membranes and get into cells and cell nuclei by isolating treated cells and nuclei and determining their ruthenium content by graphite furnace atomic absorption method (GFAAS). The GFAAS data show that the two examined complexes [delta][delta]-P and [delta]-MP are able to quickly penetrate into cancer cells (H-358) and concentrate in nuclei, which is postulated due to their high binding affinity to DNA.

Book Thiolato Bridged Arene Ruthenium Complexes Synthesis Molecular Structure Reactivity and Anticancer Activity of the Dinuclear Complexes arene sub 2 sub Ru sub 2 sub SR sub 2 sub Cl sub 2 sub

Download or read book Thiolato Bridged Arene Ruthenium Complexes Synthesis Molecular Structure Reactivity and Anticancer Activity of the Dinuclear Complexes arene sub 2 sub Ru sub 2 sub SR sub 2 sub Cl sub 2 sub written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Design Synthesis and Activation of Ruthenium Arene Anticancer Complexes

Download or read book Design Synthesis and Activation of Ruthenium Arene Anticancer Complexes written by Soledad Betanzos Lara and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Synthesis Characterization and Anticancer Effect of Photoactivatable Ruthenium II Bipyridyl Complexes in Vitro and in Vivo

Download or read book Synthesis Characterization and Anticancer Effect of Photoactivatable Ruthenium II Bipyridyl Complexes in Vitro and in Vivo written by Stephanie J. Mehanna and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Synthesis Spectroscopic Characterization and Antitumoural Evaluation of Cationic Ruthenium II Cp Arene Full sandwich Complexes for the Treatment of Cancer

Download or read book Synthesis Spectroscopic Characterization and Antitumoural Evaluation of Cationic Ruthenium II Cp Arene Full sandwich Complexes for the Treatment of Cancer written by Bradley Thomas Loughrey and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Dimethyl Sulfoxide Ruthenium II Complexes of Thiosemicarbazones and Semicarbazone Synthesis Characterization and Biological Studies

Download or read book Dimethyl Sulfoxide Ruthenium II Complexes of Thiosemicarbazones and Semicarbazone Synthesis Characterization and Biological Studies written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: