Download or read book Synthesis Characterisation and Antitumour Activity of Platinum and Ruthenium Complexes Containing Derivatives of Ethylenediamine EDTA and Mercaptoheterocycles written by Joseph Jolley and published by . This book was released on 1998 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Study of Platinum II and Platinum IV Complexes of EDTA Derivatives as Potential Antitumour Agents written by Colm J. Campbell and published by . This book was released on 1996 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Syntheses Characterization and Preliminary Evaluation of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands written by Stephen Mensah and published by . This book was released on 2019 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platinum-based drugs have over the years been administered in the treatment of tumours.Unfortunately, platinum resistance and the severe side effects associated with the treatments has necessitated the research for new anti-cancer drugs. Ruthenium(II) and Ruthenium(III) complexes have shown promise as useful alternative anticancer agents. The lead candidates include the Ru(II) complex RAPTA-C, a ruthenium(II)-arene complex [Ru(Îʺ6-p-cymene)Cl2(1,3,5-triaza-7-phosphaadamantane)] and the Ru(III) complex NAMI-A [imidazoleH][trans-Ru(imidazole) (dimethyl sulfoxide)Cl4]. Both compounds have shown potent cytotoxic activity in several primary human tumor models. Unfortunately, NAMI-A could not advance in clinical evaluations due to limited efficacy in vivo, while the clinical evaluation of RAPTA-C is unknown. Therefore, there is a need for novel cancer therapeutics that have high biological activity, are relatively easy to synthesize, and can readily be modified. This work focuses on the use of 2-acetylpyridine and 2-pyridinecarboxaldehyde for the synthesis, characterization, and preliminary evaluation of derivatives of both the RAPTA-C and NAMI-A anticancer complexes containing Schiff base ligands. Here, the results of the synthesis of these compounds and their subsequent characterization using 1H NMR, MS, fluorescence and UV-Vis spectroscopies are presented.
Download or read book Synthesis Characterization and Anti tumour Activity of Platinum Complexes written by S. J. Haneef and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ruthenium and Other Non Platinum Metal Complexes in Cancer Chemotherapy written by Etienne Baulieu and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book Synthesis and characterization of new potentially anticancer mixed metal ruthenium III platinum II dimers and trimers and the interactions of the trimer Na2 trans cis trans Ru III Cl4 DMSO S u pyz 2Pt II Cl2 with DNA written by Amnon Herman and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and characterization of hetero multinuclear ruthenium platinum complexes and assessment of their potential as anticancer agents written by Isabelle Taylor and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anticancer Activity of Some Ruthenium Complexes written by Pankaj Hazarika and published by LAP Lambert Academic Publishing. This book was released on 2014-06-24 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ruthenium complexes are also important as antitumor agents and some are currently under clinical trials. It follows a novel mechanism of action with the prospect of non-cross-resistance, reduced toxicity and acquires different activity. The Ruthenium complexes are suitable towards cisplatin resistance cancer cells, and efficiently exert antitumor action, which may be in part due to the ability of ruthenium complexes to mimic the binding of iron to certain biological molecules that in fact exploits a mechanism for non-toxic transport of iron inside the body. This property is especially attractive for ruthenium complexes. The ability of ruthenium to mimic iron in binding to certain biological molecules make these complexes well suitable for medicinal use, and as an alternative for the platinum anticancer drugs in the treatment of cancer cells, resistant to cisplatin and its analogues. The water soluble Ru complexes are usually suitable for medicinal use, and several Ru based drugs have shown good anticancer activity.The Ru complexes have certain advantages than the platinum complexes due to its solubility in water and low toxicity.
Download or read book Platinum IV Complexes as Prospective Anticancer Agents written by Xiao Liu and published by . This book was released on 2023* with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, Pt(II)-based chemotherapy drugs, such as cisplatin, oxaliplatin, and carboplatin, have been among the most effective drugs for cancer treatment. They have been widely used in various malignant solid tumors, including lung cancer, colorectal cancer, testicular cancer, ovarian cancer, bladder cancer, and head and neck cancer. Despite the well-documented success, there are still challenges to be addressed, such as intrinsic and acquired resistance, as well as side effects including nephrotoxicity, neurotoxicity, and cardiotoxicity. To maximize their effectiveness and broaden their therapeutic potential, researchers have devoted a lot of effort to exploring new derivatives and combination therapies. Among these efforts, Pt(IV) complexes, acting as prodrugs that can be activated to release active Pt(II) species, have exhibited great promise. Tremendous efforts have been devoted to exploring new synthesis approaches, elucidating structure-activity relationships, and designing novel Pt(IV) complexes that incorporate biologically active or therapeutically effective ligands. The aim is to enhance drug efficiency through increasing cytotoxicity, achieving more targeted delivery, enabling oral availability, and circumventing drug resistance, among other goals.The specific areas of focus include i) Analysis of the reduction capacity, including the determination of reduction potential (Ep) and the assessment of reduction in the presence of small reducing agents like ascorbic acid; ii) lipophilicity versus cellular accumulation; iii) stability study; iv) binding with 9-methylguanine (a simple DNA model); v) biological activities including cytotoxicity, ROS generation, cellular accumulation, COX inhibition, apoptosis induction, and more.
Download or read book New Antitumor active Dinuclear Platinum II Complexes written by Seiji Komeda and published by . This book was released on 2002 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of New Ruthenium 2 Compounds with Potential Anticancer Activity written by Barbara Serli and published by . This book was released on 2004 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Ruthenium Based Complexes Having Potential Anticancer Activity written by Julie Risse and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Anticancer Activity of Long Chain Isonicotinic Ester Ligand Containing Arene Ruthenium Complexes and Nanoparticles written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Antitumor Activity of Some Platinum Complexes written by Sheryl Lynn Doran and published by . This book was released on 1984 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Strategies for the Design of Platinum Anticancer Drug Candidates written by Justin Jeff Wilson and published by . This book was released on 2013 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: (cont'd) Chapter 6. Synthesis, Characterization, and Cytotoxicity of Platinum(IV) Dicarbamate Complexes The reaction of cis,cis,trans-[Pt(NH3)2Cl2(OH)2] with alkyl and aryl isocyanates (RNCO) in DMF afforded dicarbamate complexes of the general formula cis,cis,trans- [Pt(NH 3)2Cl 2(O 2CNHR)2]. The resulting complexes were fully characterized by X-ray crystallography, multinuclear NMR spectroscopy, and cyclic voltammetry. The anticancer activities of these complexes were assessed in human lung cancer (A549) and human lung fibroblast (MRC-5) cell lines. Although no clear structure-activity relationships could be delineated, the complexes exhibited activity on the same order of magnitude as that of the clinically established drug cisplatin. Therefore, the reaction of cis,cis,trans-[Pt(NH3)2Cl 2(OH)2] with isocyanates provides a powerful new synthetic pathway to functionalize platinum(IV) anticancer agents. Appendix A. Aqueous Electrochemistry of a Platinum(IV) Prodrug Electrochemical studies of cis,cis,trans-[Pt(NH3)2Cl2(OAc) 2] in aqueous media were carried out. Cyclic voltammetry in pH 7.4 phosphate-buffered saline with glassy carbon and Pt disk working electrodes gave substantially different peak potentials for the irreversible reduction feature. Under these conditions, the glassy carbon electrode was plated with platinum metal derived from the platinum(IV) complex, as determined by cyclic voltammetry and chronoamperometry experiments. The bulk electrolysis of cis,cis,trans-[Pt(NH3)2Cl2(OAc)2] in aqueous solution at a carbon felt working electrode was investigated by 1H NMR spectroscopy. These studies indicate ligand loss upon reduction from both axial and equatorial sites of the platinum(IV) complex. Appendix B. Targeting the Mitochondria with Platinum Anticancer Agents using Mitochondria-Penetrating Peptides Early results of a collaborative effort with the lab of Professor Shana 0. Kelley at the University of Toronto to deliver platinum anticancer agents to the mitochondria are presented. Succinylacetone (Hsuccac) was used as a leaving group ligand for a cis-diammineplatinum(II) complex. The complex [Pt(succac)(NH 3)2](NO3), which contains a terminal, uncoordinated carboxylic acid functional group, was prepared and fully characterized. This complex was conjugated to a mitochondria-penetrating peptide (MPP) using standard solid-phase coupling chemistry. The anticancer activity of the Pt-MPP construct was tested in both wild-type and cisplatin-resistant ovarian cancer cell lines, A2780 and A2780CP70. Although less potent than cisplatin, the construct is equally toxic to both cell lines, thereby indicating that targeting the mitochondria provides a viable strategy for circumventing resistance to platinum drugs. Appendix C. Synthesis and Characterization of Several Novel Platinum Complexes Throughout the course of this thesis work, several platinum complexes were synthesized and characterized, but ultimately not fully pursued as potential anticancer agents. These species include platinum compounds with dichloroacetate, 2,2'-bis(1- methylimidazolyl)phenylmethoxymethane (BIPhMe), nitrogen mustard-containing, and nitroimidazole-derivatized ligands. The syntheses and characterization of these compounds are reported. Crystal structures are described for several of them.
Download or read book Characterization of the Anticancer Properties of Ruthenium derived Compounds written by Vania Vidimar and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Water soluble Arene Ruthenium Complexes Containing Pyridinethiolato Ligands Synthesis Molecular Structure Redox Properties and Anticancer Activity of the Cations sup 6 sup arene Ru i p i SC sub 5 sub H sub 4 sub NH sub 3 sub sup 2 sup written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
