Download or read book Synthesis and Surface Functionalization of Iron Oxide Nanoparticles Towards Radiolabelling for the Application in Molecular Imaging written by Aladdin Hussein and published by . This book was released on 2012 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. - Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques - Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike - Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Download or read book Synthesis Surface Functionalization and Biological Testing of Iron Oxide Nanoparticles for Development as a Cancer Therapeutic written by Stanley Eugene Gilliland (III) and published by . This book was released on 2015 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxide nanoparticles are highly researched for their use in biomedical applications such as drug delivery, diagnosis, and therapy. The inherent biodegradable and biocompatible nanoparticle properties make them highly advantageous in nanomedicine. The magnetic properties of iron oxide nanoparticles make them promising candidates for magnetic fluid hyperthermia applications. Designing an efficient iron oxide nanoparticle for hyperthermia requires synthetic, surface functionalization, stability, and biological investigations. This research focused on the following three areas: optimizing synthesis conditions for maximum radiofrequency induced magnetic hyperthermia, designing a simple and modifiable surface functionalization method for specific or broad biological stability, and in vitro and in vivo testing of surface functionalized iron oxide nanoparticles in delivering effective hyperthermia or radiotherapy. The benzyl alcohol modified seed growth method of synthesizing iron oxide nanoparticles using iron acetylacetonate as an iron precursor was investigated to identify significant nanoparticle properties that effect radiofrequency induced magnetic hyperthermia. Investigation of this synthesis under atmospheric conditions revealed a combination of thermal decomposition and oxidation-reduction mechanisms that can produce nanoparticles with larger crystallite sizes and decreased size distributions. Nanoparticles were easily surface functionalized with (3-Glycidyloxypropyl)trimethoxysilane (GLYMO) without the need for organic-aqueous phase transfer methods. The epoxy ring on GLYMO facilitated post-modifications via a base catalyzed epoxy ring opening to obtain nanoparticles with different terminal groups. Glycine, serine, [gamma]-aminobutryic acid (ABA), (S)-( - )-4-amino-2-hydroxybutyric acid (SAHBA), ethylenediamine, and tetraethylenepentamine were successful in modifying GLYMO coated-iron oxide nanoparticles to provide colloidal and varying biological stability while also allowing for further conjugation of chemotherapeutics or radiotherapeutics. The colloidal stability of cationic and anionic nanoparticles in several biologically relevant media was studied to address claims of increased cellular uptake for cationic nanoparticles. The surface functionalized iron oxide nanoparticles were investigated to determine effects on cellular uptake and viability. In vitro tests were used to confirm the ability of iron oxide nanoparticles to provide effective hyperthermia treatment. S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (DOTA) was coupled to SAHBA and carboxymethylated polyvinyl alcohol surface functionalized iron oxide nanoparticles and radiolabeled with 177Lu. The capability of radiolabeled iron oxide nanoparticles for delivering radiation therapy to a U87MG murine orthotopic xenograft model of glioblastoma was initially investigated.
Download or read book Expanding Applications of Iron Oxide Nanoparticles by Surface Functionalization written by Chuansong Duanmu and published by . This book was released on 2009 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this dissertation, research efforts mainly focused on exploring the applications of superparamagnetic iron oxide nanoparticles (SPIONs) in MR imaging and nanocatalysis via surface functionalization.
Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-09-08 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
Download or read book Green Nanochemistry written by and published by . This book was released on 2012 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine.
Download or read book Iron Oxide Nanoparticle Surface Modification written by Richard Hoff and published by . This book was released on 2019 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional nanomaterials can be engineered to aid in the diagnosis of diseases, enable efficient drug delivery, monitor treatment progress over time, and evaluate treatment outcomes. This strategy, known as theranostics, focuses on the combination of diagnostic and therapeutic techniques to provide new clinically safe and efficient personalized treatments. The evaluation of different nanomaterials' properties and their customization for specific medical applications has therefore been a significant area of interest within the scientific community. Iron oxide nanoparticles, specifically those based on iron (II, III) oxide (magnetite, Fe3O4), have been prominently investigated for biomedical, theranostic applications due to their documented superparamagnetism, high biocompatibility, and other unique physicochemical properties. The aim of this thesis is to establish a viable set of methods for preparing magnetite (iron oxide) nanoparticles through hydrothermal synthesis and modifying their surfaces with organic functional groups in order to both modulate surface chemistry and facilitate the attachment of molecules such as peptides via covalent bond formations. Modifying their surfaces with biomolecules such as peptides can further increase their uptake into cells, which is a necessary step in the mechanisms of their desired biomedical applications. The methods of nanoparticle synthesis, surface functionalization, and characterization involving electron microscopy (e.g., SEM, TEM), zeta potential measurements, size analysis (i.e., DLS), and FT-IR spectroscopy will be presented.
Download or read book Molecular Imaging written by Bernhard Schaller and published by BoD – Books on Demand. This book was released on 2012-03-16 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book gives an exceptional overview of molecular imaging. Practical approach represents the red thread through the whole book, covering at the same time detailed background information that goes very deep into molecular as well as cellular level. Ideas how molecular imaging will develop in the near future present a special delicacy. This should be of special interest as the contributors are members of leading research groups from all over the world.
Download or read book Metal Oxide Nanoparticles written by Oliver Diwald and published by John Wiley & Sons. This book was released on 2021-09-10 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ein umfassendes Referenzwerk für Chemiker und Industriefachleute zum Thema Nanopartikel Nanopartikel aus Metalloxid sind ein wesentlicher Bestandteil zahlreicher natürlicher und technologischer Prozesse ? von der Mineralumwandlung bis zur Elektronik. Darüber hinaus kommen Metalloxid-Nanopartikel in Pulverform im Maschinenbau, in der Elektronik und der Energietechnik zum Einsatz. Das Werk Metal Oxide Nanoparticles: Formation, Functional Properties and Interfaces stellt die wichtigsten Synthese- und Formulierungsansätze bei der Nutzung von Metalloxid-Nanopartikeln als Funktionsmaterialien vor. Es werden die üblichen Verarbeitungswege erklärt und die physikalischen und chemischen Eigenschaften der Partikel mithilfe von umfassenden und ergänzenden Charakterisierungsmethoden bewertet. Dieses Werk kann als Einführung in die Formulierung von Nanopartikeln, ihre Grenzflächenchemie und ihre funktionellen Eigenschaften im Nanobereich genutzt werden. Darüber hinaus dient es zum vertiefenden Verständnis, denn das Buch enthält detaillierte Angaben zu fortschrittlichen Methoden bei der physikalischen, chemischen, Oberflächen- und Grenzflächencharakterisierung von Metalloxid-Nanopartikeln in Pulvern und Dispersionen. *Erläuterung der Anwendung von Metalloxid-Nanopartikeln und der wirtschaftlichen Auswirkungen *Betrachtung der Partikelsynthese, einschließlich der Grundsätze ausgewählter Bottom-up-Strategien *Untersuchung der Formulierung von Nanopartikeln mit einer Auswahl von Verarbeitungs- und Anwendungswegen *Diskussion der Bedeutung von Partikeloberflächen und -grenzflächen für Strukturbildung, Stabilität und funktionelle Materialeigenschaften *Betrachtung der Charakterisierung von Metalloxid-Nanopartikeln auf verschiedenen Längenskalen In diesem Buch finden Forscher im akademischen Bereich, Chemiker in der Industrie und Doktoranden wichtige Erkenntnisse über die Synthese, Eigenschaften und Anwendungen von Metalloxid-Nanopartikeln.
Download or read book Biocompatible Hybrid Oxide Nanoparticles for Human Health written by Inna V. Melnyk and published by Elsevier. This book was released on 2019-06-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocompatible Hybrid Oxide Nanoparticles for Human Health: From Synthesis to Applications explores the synthesis, structure, properties and applications of functionalized oxide nanoparticles. The books shows the applications of materials depending on their composition and structure, with a focus on silicon, titanium and iron oxides, each of which was chosen because of their unique features, including silica because it is chemically resistant to most organic solvents, harmless to living organisms, can thicken flowable formulations, and increase the strength of materials, titania for its unique chemical, optical, electrophysical and bactericidal properties, and iron-containing materials because they possess important magnetic properties. - Shows how oxide nanoparticles are being used to solve current problems in the fields of environmental protection, medicine, and in the creation of "smart" materials - Includes case studies that explore the major characteristics and applications of silica, titania and iron oxide nanomaterials - Discusses the use of biocompatible oxide nanostructures in the development of new sensing technology
Download or read book Characterization and Functionalization of Iron oxide Nanoparticles for Use as Potential Agents for Cancer Thermotherapy written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents experimental studies of iron oxide nanoparticle synthesis, functionalization, and intracellular hyperthermal effects on murine macrophages as a model in vitro system. Colloidal suspensions of magnetic nanoparticles (MNPs) are of particular interest in Magnetic Fluid Hyperthermia (MFH). Iron oxide nanoparticles (IONPs) have garnered great interest as economical, biocompatible hyperthermia agents due to their superparamagnetic activity. Here we seek to optimize the synthetic reproducibility and in vitro utilization of IONPs for application in MFH. We compared aqueous synthetic protocols and various protective coating techniques using various analytical techniques and in vitro assays to assess the biocompatibility and feasibility of the various preparations of nanoparticles. Using a co-precipitation of iron salts methodology, iron oxide nanoparticles (IONPs) with an average diameter of 6-8nm were synthesized and stabilized with carboxylates. By performing calorimetry measurements in an oscillating magnetic field (OMF) with a frequency of 500 kHz and field strength of 0.008Tesla the superparamagnetic behavior of these particles was confirmed. To further investigate these IONPs in a biological application, citric acid-stabilized particles, in conjunction with heat generated by these IONPs when exposed to an OMF, were assessed to determine their effects on cell viability in a RAW 267.4 murine macrophage model system. Our results show that 91.5-97% of cells that have ingested IONPs die follow exposure to an OMF. Importantly, neither the IONPs (at applicable concentrations) nor the OMF show cytotoxic effects. These particular particles have promising preliminary results as hyperthermic agents in both the current literature and simple, proof-of-concept experiments in our laboratory setting. We present experimental results for the synthesis, characterization, and utilization of iron oxide nanoparticles in MFH. Our results show that while IONPs have potential in MFH, efforts to advance IONPs from laboratory to clinical contexts, where reliable generative techniques and consistent performance properties are necessary, will require an understanding of the influence of the diverse intrinsic structural and magnetic characteristics as well as surface chemistry of nanoparticles, as well as the mechanisms of particle uptake and cell death due to intracellular hyperthermia.
Download or read book Design of Functionalized Nanoparticles as Imaging Agents for Cancer written by José Alejandro Barreto Solano and published by . This book was released on 2012 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the synthesis and characterization of three different generations of iron oxide magnetic nanoparticles derivatized with macrocyclic ligands for application as bi-modal imaging agents in the detection of cancer tumors by Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). The nanoparticles have been modified with polyethyleneglycol (PEG) in order to avoid uptake by the Reticuloendothelial System (RES), whilst the macrocyclic ligands have been introduced for chelation of the radionuclide 64Cu2+, which is detectable by PET. Apart from being a platform for the transport of the radionuclide complexes, the magnetic nanoparticles themselves act as MRI contrast agents and can be used for hyperthermia treatment of cancer due to their super paramagnetic nature. Synthesis of the first generation nanoparticles involved co precipitation of the core nanoparticles from a solution of iron(II) and iron(III) salts through addition of base. The macrocycles 1,4-bis(2-pyridylmethyl)-1,4,7-triazacyclononane (dmptacn), 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) were reacted with glycidyloxypropyltriethoxysilane (GPTES) to form the corresponding siloxane derivatives, which were then hydrolyzed over the surface of the nanoparticles to form a stable coating. Macrocycle loadings of the order of 0.2 mmol/g were achieved using this methodology, and the mean diameter of the nanoparticles was found to be ca. 7 nm, respective of the ligand used. Light scattering measurements showed that the particles form aggregates in solution, with a hydrodynamic size of 150-200 nm. The nanoparticles could be rapidly radiolabeled with 64Cu2+. Challenge experiments performed with an excess of cyclam indicated that the nanoparticles derivatized with dmptacn were the most resistant to 64Cu2+ leaching. These particles were also found to be the most stable in rat plasma. A second generation of nanoparticles was synthesized in order to diminish the aggregation of the nanoparticles. This involved synthesis of the core nanoparticles by co precipitation, followed by surface coating with oleic acid, which provided enhanced stability (reduced aggregation) in organic media. Displacement of the oleic acid chains with polyethylene glycol silane (PEG-silane) derivatives was used to produce a stable coating on the nanoparticles and to render them water soluble. Two different PEG-silane molecules, with different PEG chain lengths (Mn 250 and 600), were used to modified the nanoparticles. It was found that the nanoparticles coated with the longer PEG chains (PEG600) were less susceptible to aggregation in aqueous media. The nanoparticles were also functionalized with different macrocycles through amide coupling to the terminal carboxylic acid groups of the PEG chains. The nanoparticles were found to bind 64Cu2+both specifically (via the macrocycles) and nonspecifically, however the weakly boundions could be removed by addition of cyclam. In addition to MRI and PET, these second generation nanoparticles would be suitable for use in hyperthermia treatment as they possess a good specific absorption rate. The third generation nanoparticles consisted of iron oxide particles synthesized by thermal decomposition of iron oleate in the presence of oleic acid. Substitution of the surface oleate molecules by ligand exchange reaction with a PEG 600-silane derivative produced water dispersible nanoparticles with narrower size distribution and smaller hydrodynamic size than the first two generations of nanoparticles. The nanoparticles were found to accumulate in the liver after injection, as revealed by in vivo imaging studies performed on rats. The particles were further functionalized with the 64Cu2+ complex of a new dmptacn derivative, via the free carboxyl groups of the PEG chains, to produce an agent suitable for dual modal MRI-PET imaging.
Download or read book Metal Oxide Nanoparticles in Organic Solvents written by Markus Niederberger and published by Springer Science & Business Media. This book was released on 2009-09-17 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Oxide Nanoparticles in Organic Solvents discusses recent advances in the chemistry involved for the controlled synthesis and assembly of metal oxide nanoparticles, the characterizations required by such nanoobjects, and their size and shape depending properties. In the last few years, a valuable alternative to the well-known aqueous sol-gel processes was developed in the form of nonaqueous solution routes. Metal Oxide Nanoparticles in Organic Solvents reviews and compares surfactant- and solvent-controlled routes, as well as providing an overview of techniques for the characterization of metal oxide nanoparticles, crystallization pathways, the physical properties of metal oxide nanoparticles, their applications in diverse fields of technology, and their assembly into larger nano- and mesostructures. Researchers and postgraduates in the fields of nanomaterials and sol-gel chemistry will appreciate this book’s informative approach to chemical formation mechanisms in relation to metal oxides.
Download or read book Synthesis and Functionalization of Iron Oxide Nanoparticles and Their Application in Hybrid Materials written by Phillip Georg Daniel and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Applications of Magnetic Nanoparticles written by Nguyen TK Thanh and published by CRC Press. This book was released on 2018-02-06 with total page 1137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.
Download or read book Iron Oxide Nanoparticles and Their Applications written by Patricia Villegas and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxide nanoparticles demonstrate a number of unique properties, including superparamagnetism, biocompatibility, and non-toxicity, which make them an ideal candidate for a variety of applications, as described in this book. Chapter One deals with the recent advances in various synthetic procedures of iron oxide-based nanocomposites, their characterization methods, and their potential applications in energy storage devices, supercapacitors, fuel cells, and more. Chapter Two summarizes current applications of immobilized enzymes based on iron oxide magnetic nanoparticles and discusses future growth prospects. Chapter Three reviews the properties and applications of enzymatic sensors in exploiting tyrosinase, glucose oxidase, and other enzymes for sensing a broad range of biomedical species. Chapter Four discusses magnetic magnetite and maghemite iron oxide nanoparticles from a variety of perspectives. Chapter Five describes how nano iron oxides could be used to remove pollutants from the environment. Chapter Six provides a comprehensive review of the catalytic applications of iron oxide nanoparticles in organic synthesis, high temperature reactions, gas-phase processes, wastewater treatment and supercritical upgradation of heavy petroleum oils. Chapter Seven details the photocatalytic degradation of a class of toxic, aromatic pollutants, namely, phenols and substituted phenols using different types of photocatalysts in the nano size range for effective removal these compounds from water bodies. Lastly, Chapter Eight elucidates various magnetic nanomaterials-based adsorbents used in adsorption techniques for wastewater treatment.
