Download or read book Synthesis and Characterization of Ruthenium and Manganese Mono and Bimetallic Complexes Towards the Photoactivated Release of Therapeutic Molecules written by Rachael Pickens and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Cyclometalated Ruthenium II Complexes for Applications in Photoactivated Cancer Therapy written by Julia A. McCain and published by . This book was released on 2016 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Download or read book Ruthenium Complexes written by Alvin A. Holder and published by John Wiley & Sons. This book was released on 2018-02-27 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.
Download or read book Synthesis and Characterization of Ruthenium Complexes with N N P P and N P 2 Donor Sets written by Xinwei Yang and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of nonlinear effects, both the theory and measurement techniques have been developed significantly, especially since the invention of the laser. However, structure-NLO property relationships for organometallics as well as their NLO mechanisms are far less explored than those of organic molecules and inorganic salts. The greater flexibility and exceptionally large NLO responses of organometallic compounds attracts chemists to this field. Modification of coordinated co-ligands in organometallic systems has influence on the NLO merit by introducing new electronic charge-transfer transitions, oxidation state and coordination sphere of the metal centers. In this work, the donor sets of the ruthenium complexes were modified from the most investigated (P-P)(P-P) to (N-N)(P-P) and (N-P)2 and a series of ruthenium complexes were synthesized and characterized. In Chapter 2, the study of the Ru(N-N)(P-P) complexes is detailed. Three bidentate diphosphine ligands (dppe, dppb and dppf) and one diimine ligand (tert-Bu-bpy) were selected for this study as the diphosphine and diimine ligands, respectively. Ruthenium halide and mono-alkynyl complexes were obtained successfully. Their optical, electrochemical and spectroelectrochemical properties were examined and are discussed. The formation of eta3- and eta1-butenynyl complexes was confirmed by single-crystal X-ray diffraction. Attempts towards bis-alkynyl complexes were made, but no conclusive evidence could be obtained to confirm the successful synthesis of this species. In Chapter 3, the focus of the work is the study of ruthenium complexes with a (N-P)2 donor set. Two iminophosphine ligands, 2-(diphenylphosphino)pyridine (PPh2py) and 8-(diphenylphosphino)quinoline (PPh2qn), were selected for this study. The cis-RuCl2(N-P) complexes and the corresponding dimers were synthesized and characterized. Their optical and electrochemical properties were measured and are discussed. In Chapter 4, the quadratic and cubic nonlinear optical properties of organometallic complexes were explored by hyper-Rayleigh scattering (HRS) and frequency-depentdent Z-scan techniques, respectively. The first hyperpolarizabilities of the ruthenium halide and mono-alkynyl complexes described in Chapter 2 were determined by HRS measurements. The second hyperpolarizabilities of some organometallic complexes synthesized by the Humphrey group and the collaborators were measured by the Z-scan technique.
Download or read book Design Synthesis and Characterization of Ruthenium ii and Rhenium i Complexes with Functionalized Ligands for Photo And Electrochemi Luminescence Solvatochromism Molecular Recognition and HPLC Separation Studies written by Meijin Li and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Design, Synthesis and Characterization of Ruthenium(II) and Rhenium(I) Complexes With Functionalized Ligands for Photo-and Electrochemi- Luminescence, Solvatochromism, Molecular Recognition and HPLC Separation Studies" by Meijin, Li, 李梅金, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DESIGN, SYNTHESIS AND CHARACTERIZATION OF RUTHENIUM(II) AND RHENIUM(I) COMPLEXES WITH FUNCTIONALIZED LIGANDS FOR PHOTO- AND ELECTROCHEMI- LUMINESCENCE, SOLVATOCHROMISM, MOLECULAR RECOGNITION AND HPLC SEPARATION STUDIES Submitted by LI MEIJIN for the degree of Doctor of Philosophy at The University of Hong Kong in July 2006 A series of ruthenium(II) and rhenium(I) diimine complexes containing thia-, selena- and aza-crowns derived from 1,10-phenanthroline, [Ru(bpy) (phen-3S)](ClO ) 2 4 2 (phen-3S = 1,13-dioxa-4,7,10-trithiacyclopentadecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-2S)](ClO ) (phen-2S = 1,7,10,16-tetraoxa-4,13-dithiacyclohexa- 2 4 2 dodecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-S)](ClO ) (phen-S = 1,4,10,13- 2 4 2 tetraoxa-7-thiacyclopentadecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-Se)](ClO ) 2 4 2 (phen-Se = 1,4,10,13-tetraoxa-7-selenacyclopentadecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-OEt](ClO ) (phen-OEt = 5,6-diethoxy-[1,10]phenanthroline), 2 4 2 [Ru(bpy) (phen-2NH)](ClO ) (phen-2NH = 1,13-diaxa-4,7,10-trioxacyclopenta- 2 4 2 decano[2,3-f][1,10]phenanthroline), [Re(CO) (py)(phen-3S)]PF, [Re(CO) (py)(phen-S)]OTf 3 6 3 and [Re(CO) (py)(phen-Se)]OTf have been synthesized and characterized, and their photophysics, electrogenerated chemiluminescence (ECL) and electrochemistry were studied. Their interaction with metal ions was investigated by UV-vis, luminescence, NMR spectroscopy and ECL. [Ru(bpy) (phen-3S)](ClO ) and [Re(CO) (py)(phen-3S)]
Download or read book Synthesis and Characterization of Ruthenium Polypyridyl Complexes written by Sangsub Han and published by . This book was released on 2000 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds written by Michał Pawel Łomzik and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main goal of this thesis was synthesis and preliminary characterization of novel ruthenium(II) polypyridyl complexes bearing biologically active molecules as potential theranostic agents. Luminescence for the diagnostic applications, and cytotoxicity for the anticancer, therapeutic applications are considered as the theranostic properties. Four new ligands containing biologically active moieties - 5-(4-4'-methyl-[2,2'-bipyridine]-4-ylbut-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (L1), 3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L2), 5,5-dimethyl-3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L3) and [1-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)-2,5-dioxoimidazolidin-4-yl]urea (L4) were synthesized and characterized. The ligands were used to obtain nine novel ruthenium(II) polypyridyl complexes. Six complexes were synthesized with ligand L1 ([Ru(bpy)2(L1)]2+, [Ru(Mebpy)2(L1)]2+, [Ru(tBubpy)2(L1)]2+, [Ru(Phbpy)2(L1)]2+, [Ru(dip)2(L1)]2+, [Ru(SO3dip)2(L1)]2-) and three with ligands L2, L3 and L4 ([Ru(bpy)2(L2)]2+, [Ru(bpy)2(L3)]2+, [Ru(bpy)2(L4)]2+) (bpy = 2,2'-bipyridine, Mebpy = 4,4'-dimethyl-2,2-bipyridine, tBubpy = 4,4'-tert-butyl-2,2'-bipyridine, Phbpy = 4,4'-diphenyl-2,2-bipyridine, dip = 4,7-diphenyl-1,10-phenantroline and SO3dip = 4,7-di-(4-sulfonatophenyl)-1,10-phenantroline). The spectroscopic and photophysical properties of those complexes were determined. The presence of ligands L1-L4 in the structure of the complex decreased luminescence quantum yield and luminescence lifetime in comparison with unmodified [Ru(bpy)3]2+ complex. The theoretical calculations have shown that ligands L1-L4 do not have influence on ruthenium core geometry. However, they increased the energy of the HOMO that resulted in a shorter band gap. The simulated electronic absorption spectra were in a good agreement with the experimental data. The interactions between the studied ruthenium complexes and human serum albumin (HSA) were investigated. All studied Ru(II) complexes exhibited strong affinity to HSA with the association constant 105 M-1s-1, which suggests formation of Ru complex-HSA adducts. It was also determined that ruthenium complexes most likely bind to the hydrophobic pocket of protein, located in Sudlow's site I in the subdomain II A. Preliminary cytotoxicity evaluation for the studied ruthenium complexes showed their cytotoxic activity towards cancer cell lines. Those results, together with good luminescence properties of the studied ruthenium complexes (luminescence lifetimes and luminescence quantum yield) make them interesting candidates for potential theranostic applications.
Download or read book Synthesis and Characterization of Building Blocks and Polynuclear Complexes of Ruthenium Osmium and Manganese written by 郭俊芳 and published by . This book was released on 2008 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Manganese IV Tetraphenylporphyrin Complexes written by Mark J. Camenzind and published by . This book was released on 1983 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of a Photoactivatable Ruthenium II Complex Bearing 2 9 diphenyl 1 10 phenanthroline written by Najwa Mansour and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Ruthenium Polypyridyl Complexes for Application in Photodynamic Therapy written by Colin R. Spencer and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Download or read book The Synthesis and Characterization of Manganese IV Porphyrin Com Plexes written by Bruce Curtis Schardt and published by . This book was released on 1984 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Evaluation of Manganese I Photoinduced CO releasing Molecules and Water soluble Lanthanide Cages written by Shabnam Pordel and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon monoxide (CO) is a toxic gas that has been known as the “silent killer” for decades. At high concentrations, CO reacts with hemoglobin, impairing its ability to transfer oxygen throughout the body. At low concentrations, however, CO has anti-cancer and anti-inflammatory effects. CO has also been shown to increase the sensitivity of certain types of cancer cells to the reactive oxygen species (ROS) produced by chemotherapeutics, thereby reducing drug resistance. One way to deliver CO in a controlled and safe manner is through the use of photoCORMs, or photoactivated CO releasing molecules. Transition metal-based photoCORMs are a class of molecules that release CO by breaking the M-CO bond upon exposure to light. In Chapters 2 and 3, my research study the effect of ligand set variation (both electronically and sterically) around the Mn(I) metal center on the photophysical and photochemical properties, as well as the assignment of photochemical intermediate formation during visible light irradiation. In Chapter 4, we designed a system that combined photo-activated CO delivery and singlet oxygen (1O2). The photophysical and photochemical properties of two Mn(I)-based photoCORMs sensitized with a luminescent BODIPY, as well as their ability to generate singlet oxygen during visible light irradiation were investigated.iv In Chapter 5, my focus was on water-soluble 3D supramolecular coordination cages (SCCs). The internal cavity incorporated in these structures allows them to encapsulate various guest molecules. Water-soluble Ln(III)-based SCCs are scarce, and the arrangement of water molecules inside the cavity, as well as the recognition properties of the latter, are mostly unknown. The study of such interactions would be of interest to the growing field of SCCs. To this end, we designed and synthesized a water-soluble Eu(III)-based supramolecular coordination cage with the general formula of Eu2L3 and a triplestranded helicate structure. The guest binding properties of the Eu2L3 cage were studied with smaller mono- and di-cationic organic guests through 1H NMR titration in D2O
Download or read book Synthesis and Characterization of Ruthenium II hispolon Complexes written by Carmen Kloer and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ruthenium written by Gary P. Keeler and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ruthenium is exceedingly rare, as it is only the 74th most abundant metal on Earth. The element is generally found in ores with the other platinum group metals in the Ural Mountains and in North and South America. Ruthenium containing-complexes are well suited for biological application owning to the unique properties of ruthenium. For example, ruthenium complexes have been utilized as cellular imaging tools, radiopharmaceutical imaging tools, and as replacements to platinum-based drugs in fighting several diseases such as cancer, malaria, Leishmania major, and Trypanosoma cruzi, to name a few. This book discusses the synthesis of ruthenium as well as the physicochemical properties and applications.
Download or read book Synthesis and Investigations of Monometallic and Bimetallic Ruthenium Complexes Exhibiting Proton coupled Electron transfer Reactions written by Sharon Vannessa Ezell and published by . This book was released on 1993 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
