Download or read book Surface Modification of Nanoparticles for Targeted Drug Delivery written by Yashwant V Pathak and published by Springer. This book was released on 2019-03-11 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.
Download or read book Surface modified PLGA Nanoparticles for Targeted Drug Delivery to Neurons written by Jingyan Li and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Functionalization and Surface Treatment of Nanoparticles written by Marie-Isabelle Baraton and published by . This book was released on 2003 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis, Functionalization and Surface Treatment of Nanoparticles is an area of crucial importance in the emerging field of nanotechnology. Controlling the surface chemical composition and mastering its modification at the nanometer scale are critical issues for high-added value applications involving nanoparticles. The basic applications of surface functionalization range from altering the wetting or adhesion characteristics and improving the nanoparticles dispersion in matrices to enhancing the catalytic properties and ordering the interfacial region, and such. The creation of specific surface sites on nanoparticles for selective molecular attachment is considered a promising approach for their applications in nanofabrication, nanopatterning, selfassembly, nanosensors, bioprobes, drug delivery, pigments, photocatalysis, LEDs, etc. This book presents novel and improved synthesis methods and approaches for controlling and functionalizing the nanoparticle surfaces to enhance the overall performance of the nanoparticles for targeted applications.
Download or read book Nanoparticulate Drug Delivery Systems written by Deepak Thassu and published by CRC Press. This book was released on 2007-03-30 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e
Download or read book Nanotechnology for Cancer Therapy written by Mansoor M. Amiji and published by CRC Press. This book was released on 2006-12-19 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo
Download or read book Surface Modification of Caboxyl functionalized Polymeric Nanoparticles for Attachment of Targeting Peptides written by Amit Kulkarni and published by . This book was released on 2009 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular targeting of drug delivery systems represents a promising approach to reduce adverse effects by limiting release of pharmacological agent to desired target site. Controlled surface modification of nanoparticles by specific ligands can facilitate maximum receptor binding and cellular internalization, thereby increasing efficacy of targeting. This research attempts to establish the foundation for ligand-mediated, covalent surface modification of prefabricated carboxyl functionalized polymeric nanoparticles. Control over size and surface charges affecting stability is demonstrated through fabrication of particles in the absence and presence of a stabilizer. Covalent conjugation chemistry for amidation of surface carboxyl groups to amine-bearing ligands is explored and challenges in separating unbound ligands without compromising particle stability are presented. Successful synthesis and purification of a transcytosis-facilitating peptide sequence ( -RYRGDLGRR- ) and its analogues are outlined. Lastly, increased transport of peptide-modified nanoparticles across BeWo cell monolayers, an in vitro model of the human placenta is demonstrated. Preliminary competition studies showing this increased transport of peptide-functionalized particles to be a result of receptor mediated interactions are put forth. In summary, we provide sufficient experimental evidence to suggest increased transport properties of modified particles to be dependent on covalent surface conjugation of appropriate ligands. This establishes the foundation to evaluate controlled expression of targeting ligands for optimizing targeting efficiency of delivery systems.
Download or read book Nanomaterials for Drug Delivery and Therapy written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2019-03-14 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers
Download or read book Drug Delivery with Targeted Nanoparticles written by Yılmaz Çapan and published by CRC Press. This book was released on 2021-11-30 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.
Download or read book Nanoparticles for Drug Delivery written by K. S. Joshy and published by Springer Nature. This book was released on 2021-06-21 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the reader to drug delivery with specific emphasis on the use of nanoparticles. It covers properties, characterization, and preparation of different types of nanoparticles and discusses recent advances in their structural design and biomedical application, as well as the issues and challenges associated with their design and use. Some of the topics covered include the potential application of nanoparticles in biomedical fields, hazards associated with use of nanoparticles for drug delivery, size-dependent factors in drug delivery applications, different organic, inorganic and their hybrid systems used in drug delivery, etc. It also highlights use of nanoparticles in controlled and targeted drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release. Additionally, it also focuses on biomimetic nanoparticles, challenges faced in the designing of nanoparticles for drug delivery in cancer, viral and bacterial diseases. The contents of this volume will be useful to researchers and professionals working on advances in targeted drug delivery systems.
Download or read book Nanoscale Materials in Targeted Drug Delivery Theragnosis and Tissue Regeneration written by Sudesh Kumar Yadav and published by Springer. This book was released on 2016-06-04 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind to offer a comprehensive and up-to-date discussion of the use of nanoscale materials for biomedical applications, with a particular focus on drug delivery, theragnosis and tissue regeneration. It also describes in detail the methods used in the preparation of nanoparticles. Response of nanoparticles in biological systems are also explored. Nanotechnology has led to the advent of a new field, nanomedicine, which focuses on the use of nanomaterials as drug-delivery vehicles to develop highly selective and effective drugs. The combination of molecular imaging and nanotechnology has produced theragnostic nanoparticles, which allow the simultaneous detection and monitoring of diseases. Nanotechnology can also be combined with biomaterials to create scaffolds for tissue regeneration. Further, significant advances have been made in the areas of drug delivery, theragnostic nanoparticles and tissue regeneration materials. Some nanomedicines and tissue regeneration materials are already commercially available, while others are undergoing clinical trials, and promising results have been documented. Despite the rapid advances in nanomedicine, there is a relative dearth of literature on the biomedical applications of nanoscale materials.
Download or read book Nanoparticle Drug Delivery Systems for Cancer Treatment written by Hala Gali-Muhtasib and published by CRC Press. This book was released on 2020-02-19 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
Download or read book Role of Novel Drug Delivery Vehicles in Nanobiomedicine written by Rajeev K. Tyagi and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Nanotechnology and Nanomedicine introduces non-experts to the world of nanomedicine and its evolving organizational infrastructure. Considering the fluid nature of nano breakthroughs and the delicate balance between benefits and consequences as they apply to medicine, readers at all levels will gain a practical, understandable base of information on these developments so that they may take the greatest advantage of them. This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects and provides an ideal foundation upon which to plan and make decisions.
Download or read book Pharmaceutical Nanotechnology written by Volkmar Weissig and published by Humana. This book was released on 2020-08-14 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details protocols on formulation, surface modification, characterization, and application of a variety of pharmaceutical nanocarriers such as micelles, nanoparticles, dendrimers, carbon dots, polymersomes, and others. Chapters are targeted toward investigators working in academic and industrial laboratories conducting research in the broad field of pharmaceutical sciences, with an emphasis on drug delivery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Pharmaceutical Nanotechnology: Basic Protocols aims to be a source of inspiration to all investigators who are interested in the potential of the merger of nanotechnology with pharmaceutical sciences.
Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2019-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.
Download or read book Handbook of Research on Nano Drug Delivery and Tissue Engineering written by Rajakumari Rajendran and published by CRC Press. This book was released on 2022-03-10 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading researchers in the nanomedicine field from industry, academia, and government and private research institutions across the globe, the volume provides an up-to-date report on topical issues in nano-drug delivery and nanotechnological approaches to tissue engineering. The volume offers research on a variety of diverse nano-based drug delivery systems along with discussions of their efficacy, safety, toxicology, and applications for different purposes. Focusing on nanotechnology approaches to tissue engineering, this volume considers the use of hydrogel systems, nanoceria and micro- and nano-structured biomaterials for bone tissue engineering, mesenchymal stem cells, and more.
Download or read book Drug Delivery Using Nanomaterials written by Yasser Shahzad and published by CRC Press. This book was released on 2022-01-18 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.
Download or read book Nanoparticles in Healthcare written by Dileep Francis and published by Materials Research Forum LLC. This book was released on 2024-03-15 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers the use of nanoparticles in therapeutics, diagnostics, and drug delivery. Topics covered include nanomaterial fabrication, surface modification and applications; toxicity of plant-based nanomaterials; the use of herbal extracts; bioimaging; metal doped nanoparticles for drug delivery; nanoparticles designed for specific neurodegenerative conditions; theranostic nanoparticles in treating lung diseases; and glioma nanotherapy. Keywords: Nanoparticles, Toxicity, Plant-based Nanomaterials, Bioimaging, Diagnostic Nanotechnologies, Metal Doped Nanoparticles, Wound Healing, Neurodegenerative Diseases, Theranostic Nanoparticles, Lung Diseases, Glioma Therapy, Drug Delivery Systems.
