Download or read book Surface Modification of Caboxyl functionalized Polymeric Nanoparticles for Attachment of Targeting Peptides written by Amit Kulkarni and published by . This book was released on 2009 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular targeting of drug delivery systems represents a promising approach to reduce adverse effects by limiting release of pharmacological agent to desired target site. Controlled surface modification of nanoparticles by specific ligands can facilitate maximum receptor binding and cellular internalization, thereby increasing efficacy of targeting. This research attempts to establish the foundation for ligand-mediated, covalent surface modification of prefabricated carboxyl functionalized polymeric nanoparticles. Control over size and surface charges affecting stability is demonstrated through fabrication of particles in the absence and presence of a stabilizer. Covalent conjugation chemistry for amidation of surface carboxyl groups to amine-bearing ligands is explored and challenges in separating unbound ligands without compromising particle stability are presented. Successful synthesis and purification of a transcytosis-facilitating peptide sequence ( -RYRGDLGRR- ) and its analogues are outlined. Lastly, increased transport of peptide-modified nanoparticles across BeWo cell monolayers, an in vitro model of the human placenta is demonstrated. Preliminary competition studies showing this increased transport of peptide-functionalized particles to be a result of receptor mediated interactions are put forth. In summary, we provide sufficient experimental evidence to suggest increased transport properties of modified particles to be dependent on covalent surface conjugation of appropriate ligands. This establishes the foundation to evaluate controlled expression of targeting ligands for optimizing targeting efficiency of delivery systems.
Download or read book Chitooligosaccharides written by Se-Kwon Kim and published by Springer Nature. This book was released on 2022-02-23 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines the production of chitooligossacharides and their derivatives and discusses their main biological activities, biomedical applications and their role in disease prevention. Chitooligosaccharides are products of chitosan or chitin degradation, prepared by enzymatic or chemical hydrolysis of chitosan, and they consist mainly of N-acetyl glucosamine and glucosamine bonded with a glycosidic bond. Compared to chitin and chitosan, chitooligossacharides offer advantages for large-scale and commercial applications due to their solubility in water and lower molecular weight. Written by leading experts, this book is divided into four parts. The first part provides a general introduction to chitooligossacharides. The second part focuses on the bioproduction of chitooligossacharides through enzymatic synthesis and also covers physical and chemical methods of synthesis. The third part explores the major biological activities of chitooligosaccharides, including antioxidant, antimicrobial, anti-allergic, anti-inflammatory, anti-cancer and neuroprotective activities, and discusses the disease preventing mechanisms of chitooligosaccharides. In this section, readers will also find about the latest in vivo studies which support the use of chitooligosaccharides in the prevention and control of disease. The final part highlights important biomedical applications of chitooligosaccharides, including in tissue engineering, drug delivery and wound healing applications. It also includes the volume editor’s perspective on the health and safety risks of chitooligosaccharides. Given its scope, this book is useful not only for researches in the field but also for students interested in biomaterials, pharmaceuticals, marine biotechnology, nutraceuticals and food science.
Download or read book Surface Modification of Nanoparticles for Targeted Drug Delivery written by Yashwant V Pathak and published by Springer. This book was released on 2019-03-11 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.
Download or read book Single Chain Polymer Nanoparticles written by José A. Pomposo and published by John Wiley & Sons. This book was released on 2017-08-18 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Download or read book Fluorescent Nanodiamonds written by Huan-Cheng Chang and published by John Wiley & Sons. This book was released on 2018-11-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive reference on fluorescent nanodiamond physical and chemical properties and contemporary applications Fluorescent nanodiamonds (FNDs) have drawn a great deal of attention over the past several years, and their applications and development potential are proving to be manifold and vast. The first and only book of its kind, Fluorescent Nanodiamonds is a comprehensive guide to the basic science and technical information needed to fully understand the fundamentals of FNDs and their potential applications across an array of domains. In demonstrating the importance of FNDs in biological applications, the authors bring together all relevant chemistry, physics, materials science and biology. Nanodiamonds are produced by powerful cataclysmic events such as explosions, volcanic eruptions and meteorite impacts. They also can be created in the lab by high-pressure high-temperature treatment of graphite or detonating an explosive in a reactor vessel. A single imperfection can give a nanodiamond a specific, isolated color center which allows it to function as a single, trapped atom. Much smaller than the thickness of a human hair, a nanodiamond can have a huge surface area that allows it to bond with a variety of other materials. Because of their non-toxicity, nanodiamonds may be useful in biomedical applications, such as drug delivery and gene therapy. The most comprehensive reference on a topic of rapidly increasing interest among academic and industrial researchers across an array of fields Includes numerous case studies and practical examples from many areas of research and industrial applications, as well as fascinating and instructive historical perspectives Each chapter addresses, in-depth, a single integral topic including the fundamental properties, synthesis, mechanisms and functionalisation of FNDs The first book published by the key patent holder with his research group in the field of FNDs Fluorescent Nanodiamonds is an important working resource for a broad range of scientists and engineers in industry and academia. It will also be a welcome reference for instructors in chemistry, physics, materials science, biology and related fields.
Download or read book Nanostructured Biomaterials for Regenerative Medicine written by Vincenzo Guarino and published by Woodhead Publishing. This book was released on 2019-10-05 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured Biomaterials for Regenerative Medicine focuses on the definition of new trends for the design of biomaterials for biomedical applications. It includes the ex novo synthesis as well as technological strategies to manipulate them into appropriate two-dimensional (2D) and three-dimensional (3D) forms, in order to impart all the main physical, chemical, structural and biological properties requested to achieve desired clinical efficacy. This book aims at offering a concise overview of innovative platforms based on nanostructured biomaterials as a function of their chemical nature - established by a consolidated material classification i.e., polymer, ceramics and metals. For each class, emerging bioinspired systems with rapid expansion in the biomedical research area and fabricated via new enabling technologies will be proposed for the use in tissue repair/regeneration and nanomedicine. This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine. Classifies materials into three classes for comprehensive discussion Discusses design techniques to create innovative nanostructured biomaterials Looks at enabling technologies and strategies for emerging applications
Download or read book Polymer Capsules written by Ye Liu and published by CRC Press. This book was released on 2019-05-10 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are one of the most versatile and important materials used for capsule preparation despite various others available. Suitably formulated capsules can securely protect ingredients, deliver them to targeted sites, and release them expeditiously, improving functions and minimizing adverse effects. New polymers are constantly being explored to develop more efficient capsules as they are routinely used in pharmaceuticals, consumer healthcare products, nutrients, and food. This book focuses on the current state of the art of polymer-based capsules and delivery systems. It describes the formulation processes of capsules developed from redox-responsive polymers and polymer-functionalized carbon nanotubes, in addition to shedding light on coacervation of polymers for encapsulation. It reviews different active ingredients that can be used with polymer capsules in various products, encapsulation of essential oils using such capsules, and development of polymer capsules of cells and bacteriophages.
Download or read book Non Thermal Plasma Technology for Polymeric Materials written by Sabu Thomas and published by Elsevier. This book was released on 2018-10-08 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-Thermal Plasma Technology for Polymeric Materials: Applications in Composites, Nanostructured Materials and Biomedical Fields provides both an introduction and practical guide to plasma synthesis, modification and processing of polymers, their composites, nancomposites, blends, IPNs and gels. It examines the current state-of-the-art and new challenges in the field, including the use of plasma treatment to enhance adhesion, characterization techniques, and the environmental aspects of the process. Particular attention is paid to the effects on the final properties of composites and the characterization of fiber/polymer surface interactions. This book helps demystify the process of plasma polymerization, providing a thorough grounding in the fundamentals of plasma technology as they relate to polymers. It is ideal for materials scientists, polymer chemists, and engineers, acting as a guide to further research into new applications of this technology in the real world. Enables materials scientists and engineers to deploy plasma technology for surface treatment, characterization and analysis of polymeric materials Reviews the state-of-the-art in plasma technology for polymer synthesis and processing Presents detailed coverage of the most advanced applications for plasma polymerization, particularly in medicine and biomedical engineering, areas such as implants, biosensors and tissue engineering
Download or read book Nanomaterials for Cancer Therapy written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2006-07-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.
Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Download or read book Green Nanomaterials written by Shakeel Ahmed and published by Springer Nature. This book was released on 2020-03-16 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises a collection of chapters on advances in green nanomaterials. The book looks at ways to establish long‐term safe and sustainable forms of nanotechnology through implementation of nanoparticle biosynthesis with minimum impact on the ecosystem. The book looks at synthesis, processing, and applications of metal and metal oxide nanomaterials and also at bio-nanomaterials. The contents of this book will prove useful for researchers and professionals working in the field of nanomaterials and green technology.
Download or read book Green Synthesis of Nanoparticles Applications and Prospects written by Quaiser Saquib and published by Springer Nature. This book was released on 2020-10-19 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes various strategies for the synthesis of green nanoparticles using plant extracts and microbes, including the advantages and disadvantages of different methods and their applications. After discussing strategies for and the potential of green synthesis of noble metal nanoparticles, it highlights the role of the solvent system. The book then explores the stability/toxicity of nanoparticles and the associated-surface engineering techniques for achieving biocompatibility, and examines the antimicrobial efficacy of green nanoparticles with regard to various bacterial pathogens, as well as the underlying cytotoxicity mechanisms. Lastly, the book addresses the potential applications of various green nanoparticles in cancer theranostics, and reviews a number of plant-mediated nanoparticles as potential pharmaceutical agents. Given its scope, the book will be of interest to all scientists and students wanting to learn more about the synthesis and applications of green nanoparticles.
Download or read book Polymer Composites with Functionalized Nanoparticles written by Krzysztof Pielichowski and published by Woodhead Publishing. This book was released on 2018-09-22 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer Composites with Functional Nanoparticles: Synthesis, Properties, and Applications reviews the latest research in the area of polymer nanocomposites and functionalized nanoparticles, providing an introduction for those new to the field, and supporting further research and development. The book helps researchers and practitioners better understand the key role of nanoparticle functionalization for improving the compatibility of inorganic metallic nanomaterials with organic polymers, and for the fabrication of nanostructured materials with special properties. A range of nanoparticles, such as carbon nanotubes are covered, along with descriptions of the methods of functionalization to support better compatibility with polymer matrices. The book also discusses the various applications of this technology, including uses in electronics and the medical and energy industries. Summarizes the latest research in functionalized nanoparticles for modification of polymer matrices, providing a valuable platform for further research Includes functionalization of a range of nanoparticles for incorporation into nanocomposites, including carbon nanotubes, graphene, gold and silver, silica and clay Provides detailed coverage of application areas, including energy, electronics, biomedical applications, and end-of-life considerations
Download or read book Polymer and Polymer Hybrid Nanoparticles written by Stanislav Rangelov and published by CRC Press. This book was released on 2013-08-28 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric and hybrid nanoparticles have received increased scientific interest in terms of basic research as well as commercial applications, promising a variety of uses for nanostructures in fields including bionanotechnology and medicine. Condensing the relevant research into a comprehensive reference, Polymer and Polymer-Hybrid Nanoparticles: Fr
Download or read book Handbook of Nanomaterials for Industrial Applications written by Chaudhery Mustansar Hussain and published by Elsevier. This book was released on 2018-07-19 with total page 1143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nanomaterials for Industrial Applications explores the use of novel nanomaterials in the industrial arena. The book covers nanomaterials and the techniques that can play vital roles in many industrial procedures, such as increasing sensitivity, magnifying precision and improving production limits. In addition, the book stresses that these approaches tend to provide green, sustainable solutions for industrial developments. Finally, the legal, economical and toxicity aspects of nanomaterials are covered in detail, making this is a comprehensive, important resource for anyone wanting to learn more about how nanomaterials are changing the way we create products in modern industry. Demonstrates how cutting-edge developments in nanomaterials translate into real-world innovations in a range of industry sectors Explores how using nanomaterials can help engineers to create innovative consumer products Discusses the legal, economical and toxicity issues arising from the industrial applications of nanomaterials
Download or read book Nanostructures for Cancer Therapy written by Alexandru Mihai Grumezescu and published by Elsevier. This book was released on 2017-04-11 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area
Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
