Download or read book Super Pixel Diffuse Optical Tomography written by Karla Michelle Bergonzi and published by . This book was released on 2017 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging has long held promise as a clinical, bedside neuroimaging tool; however, the performance has been lacking compared to functional Magnetic Resonance Imaging (fMRI), the gold standard of functional brain imaging. Recently, High-Density Diffuse Optical Tomography (HD-DOT) has matched image resolution with fMRI and has adapted an fMRI technique which assays cerebral function without requiring task performance, known as resting-state functional connectivity, for use with optical data. HD-DOT uses safe, near-infrared light delivered via optical fibers to the head to measure oxygenation changes in the brain. The system performance of HD-DOT has been validated using tasks and resting-state functional connectivity in healthy adults but has not yet transitioned to a bedside neuroimaging tool. The final limitations are ergonomic in nature, including large console sizes and heavy caps.In this dissertation, we utilize advances in CMOS camera sensor designs to improve the ergonomics of HD-DOT systems for use in clinical care settings. The primary advantage we are leveraging to improve HD-DOT ergonomics is the increased sensitivity of CMOS sensors compared to previously used detectors. This increased sensitivity allows for a reduction in the optical fiber diameters without compromising data quality. The reduced fiber diameters significantly decrease the weight of the cap, improving wearability. The secondary advantage of CMOS sensors are their small form factors which allow for a significantly reduced console size, improving the portability of the system. The disadvantage of CMOS sensors are the low dynamic ranges (DNR), which are 100-fold lower than the DNR necessary for HD-DOT neuroimaging. To combat this disadvantage, we have developed a Super Pixel HD-DOT (SP-DOT) algorithm which uses pixel binning and electronic noise reduction to meet the required specifications for HD-DOT neuroimaging. This dissertation reports the development, testing, and validation of the SP-DOT system. Collectively, this dissertation demonstrates that advanced SP-DOT offers a practical solution to imaging brain activity in the clinic with fMRI-comparable spatial resolution.As a preliminary investigation into the utility of HD-DOT in the clinic, we imaged acute stroke patients at the bedside using a first generation, APD-based HD-DOT system with large optical fibers. By optimizing the location of the cap, we were able to image key areas of the brain while maintaining system portability and moderate cap wearability. We had success collecting resting-state data from these acute stroke patients for use in functional connectivity analysis. We developed a "Similarity" metric for each stroke patient, which is a measure of how similar the stroke patients' connectivity maps are to a healthy cohort. This similarity metric is significantly reduced over the damaged hemisphere in stroke patients and also correlates with neurological impairment.
Download or read book Diffuse Optical Tomography written by Huabei Jiang and published by CRC Press. This book was released on 2018-09-03 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging. This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including: Early-stage detection of breast tumors and prostate cancer "Real-time" functional brain imaging Joint imaging to treat progressive diseases such as arthritis Monitoring of tumor response New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.
Download or read book New Approaches to Higher Resolution Imaging in Diffuse Optical Tomography written by Ari Goldberg and published by . This book was released on 2004 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diffuse Optical Tomography and Fluorescence Diffuse Optical Tomography written by Baohong Yuan and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Diffuse Optical Tomography written by J. H. Eberly and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diffuse Optical Tomography written by J. H. Eberly and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Compressive Diffuse Optical Tomography Based on Structured Light and Monte Carlo Methods written by Ruoyang Yao and published by . This book was released on 2018 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coded Optical Imaging written by Jinyang Liang and published by Springer Nature. This book was released on with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identifying and Addressing the Error Sources in Diffuse Optical Tomography written by Murat Güven and published by ProQuest. This book was released on 2007 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Shape based image reconstruction methods for hyperspectral diffuse optical tomography written by Fridrik Larusson and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Super Resolution Optical Imaging and Microscopy written by Junle Qu and published by John Wiley & Sons. This book was released on 2023-12-15 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Super Resolution Optical Imaging and Microscopy Extremely comprehensive resource containing cutting-edge and practical knowledge of super-resolution optical imaging This book covers both the basic principles and specific technical details of super-resolution microscopy techniques. It covers the criteria to choose different fluorophores for various SRM methods and critically assesses the nitty-gritty of associated problems that are often encountered in practical applications. A progressive guide to designing the next generation of advanced fluorophores to meet the goal of advanced SR imaging studies is also put forward. Written by two well-qualified authors, the book contains exclusive content to enhance readers’ understanding on innovation of newer SRM technologies. Sample topics covered in the book include: Optical techniques, fluorescent probe design, and algorithm development Recent highlight and breakthroughs in biology using SRM methods The overall success of SRM in biological inventions The future direction and scope of the field This book is an invaluable resource for chemists and researchers/scientists involved in designing newer fluorescent materials for SRM studies. It can also assist biologists engaged in advanced biological studies using SRM by guiding them through sample preparation, image processing, and precautions to be taken in practical imaging studies.
Download or read book Diffuse Optical Tomography written by Ruixin Jiang and published by . This book was released on 2012 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse Optical Tomography has drawn more and more interests in the biomedical field over the recent couple of decades due to its ability to noninvasively recover not only tissue structural information but also functional and molecular properties. The contrasts that optical parameters could demonstrate in DOT are usually higher than those of the conventional methods. Based on these contrasts, different approaches had been developed applying DOT for imaging, and so far lots of efforts were spent on detecting breast cancer by imaging tissue absorption and scattering coefficients as well as hemoglobin concentration and oxygen saturation level. In this work, we tried to expand the ability of DOT in breast cancer detection by introducing Phase-contrast diffuse optical tomography (PCDOT). PCDOT uses near-infrared diffusing light to non-invasively reconstruct tissue refractive index (RI) distribution. RI depends on the tissue's physical and chemical properties and previous study revealed that it might serve as a promising imaging parameter in breast cancer detection. We've first developed a 2-step method to improve the PCDOT image both qualitatively and quantitatively at single-wavelength; then we've introduced a multispectral PCDOT algorithm to more efficiently reconstruct RI simultaneously with other tissue functional parameters and attempted to improve this algorithm by different structural regularization methods.
Download or read book High resolution Three D Diffuse Optical Tomography for Non invasive Functional Brain Imaging in the Sub centimeter Range written by and published by . This book was released on 2014 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sparse Reconstruction Methods in Fluorescence Diffuse Optical Tomography written by An Jin and published by . This book was released on 2012 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plasmonics and Super Resolution Imaging written by Zhaowei Liu and published by CRC Press. This book was released on 2017-06-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasmonics is an emerging field mainly developed within the past two decades. Due to its unique capabilities to manipulate light at deep subwavelength scales, plasmonics has been commonly treated as the most important part of nanophotonics. Plasmonic-assisted optical microscopy techniques, especially super-resolution microscopy, have shown tremendous potential and attracted much attention. This book aims to collect cutting-edge studies in various optical imaging technologies with advanced performances that are enabled or enhanced by plasmonics. The basic working principles, development details, and potential future direction and perspectives are discussed. Edited by Zhaowei Liu, a prominent researcher in the field of super-resolution microscopy, this book will be an excellent reference for anyone in the field of nanophotonics, plasmonics, and optical microscopy.
Download or read book Advanced Photon Counting written by Peter Kapusta and published by Springer. This book was released on 2015-04-23 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules. Combining spectrum and lifetime provides a “fingerprint” for identifying such molecules in the presence of a background. Used together with confocal detection, this permits single-molecule spectroscopy and microscopy in addition to ensemble measurements, opening up an enormous range of hot life science applications such as fluorescence lifetime imaging (FLIM) and measurement of Förster Resonant Energy Transfer (FRET) for the investigation of protein folding and interaction. Several technology-related chapters present both the basics and current state-of-the-art, in particular of TCSPC electronics, photon detectors and lasers. The remaining chapters cover a broad range of applications and methodologies for experiments and data analysis, including the life sciences, defect centers in diamonds, super-resolution microscopy, and optical tomography. The chapters detailing new options arising from the combination of classic TCSPC and fluorescence lifetime with methods based on intensity fluctuation represent a particularly unique highlight.
Download or read book Atlas of Optical Coherence Tomography for Glaucoma written by Donald L. Budenz and published by Springer Nature. This book was released on 2020-07-03 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Optical Coherence Tomography for Glaucoma is a case-based atlas intended to teach the reader how to interpret the results of OCT in glaucoma patients and glaucoma suspects. After a brief description of how OCT is used in particular situations, chapters depict actual case presentations from authors’ practices with legends that describe the case and how OCT is used to make the diagnosis of glaucoma or glaucoma progression. Emphasis is placed on where OCT can lead the clinician astray by providing false positive or false negative results resulting in misdiagnosis. The intention of the format is to make it easily digestible in a weekend read and make the practitioner comfortable with OCT interpretation. Examples are presented from all of the available OCT manufacturers.
