Download or read book Handbook of Synthetic Substrates written by H.C. Hemker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for a handbook on the use of synthetic substrates for assay of proteases of the coagulation and fibrinolytic systems became evident several years ago during the activities of the Subcommittee on Synthetic Substrates of the International Committee on Thrombosis and Haemo stasis (lCTH). Production of such a handbook, which was recommended during discussions of the ICTH at its meeting in London in 1979 was made possible by the generous efforts of Professor HC Hemker with the aid of several contributors with particular interests in the use of synthetic substrates in coagulation and fibrinolysis. As current Chairman and Secretary General of the ICTH we would like to express our sincere thanks to Professor Hemker for producing this handbook and look for ward to seeing the benefits of this tremendous effort reflected in the advancement of our understanding of thrombosis and hemostasis and the transfer of such knowledge into improved diagnosis and treatment of thrombotic and hemorrhagic disorders. Craig M Jackson Professor of Biological Chemistry Washington University School of Medicine, St. Louis, MO Chairman, ICTH Harold R Roberts Professor of Internal Medicine University of North Carolina, Chapel Hill, NC Secretary General, ICTH ix Foreword The advent of synthetic substrates for the study of blood coagulation and fibrinolysis was a significant step forward in the investigation of these systems. Both basic research and clinical laboratory investigations can profit from these advanced tools.

Download or read book Pharmacology written by R.R. Levine and published by CRC Press. This book was released on 2000-04-15 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.

Download or read book Creoles their Substrates and Language Typology written by Claire Lefebvre and published by John Benjamins Publishing. This book was released on 2011-02-17 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since creole languages draw their properties from both their substrate and superstrate sources, the typological classification of creoles has long been a major issue for creolists, typologists, and linguists in general. Several contradictory proposals have been put forward in the literature. For example, creole languages typologically pair with their superstrate languages (Chaudenson 2003), with their substrate languages (Lefebvre 1998), or even, creole languages are alike (Bickerton 1984) such that they constitute a “definable typological class” (McWhorter 1998). This book contains 25 chapters bearing on detailed comparisons of some 30 creoles and their substrate languages. As the substrate languages of these creoles are typologically different, the detailed investigation of substrate features in the creoles leads to a particular answer to the question of how creoles should be classified typologically. The bulk of the data show that creoles reproduce the typological features of their substrate languages. This argues that creoles cannot be claimed to constitute a definable typological class.

Download or read book Polymeric Coating of Supporting Substrates Background Information for Proposed Standards written by and published by . This book was released on 1987 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Establishment of a Production ready Manufacturing Process Utilizing Thin Silicon Substrates for Solar Cells written by Robert A. Pryor and published by . This book was released on 1979 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Thin films of gallium arsenide on low cost substrates written by Rockwell International. Electronics Research Center and published by . This book was released on 1979 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Evaluation of Enzyme Inhibitors in Drug Discovery written by Robert A. Copeland and published by John Wiley & Sons. This book was released on 2005-04-01 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.

Download or read book The Ecological Status of European Rivers Evaluation and Intercalibration of Assessment Methods written by Mike T. Furse and published by Springer Science & Business Media. This book was released on 2009-03-20 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The monitoring of benthic diatoms, macrophytes, macroinvertebrates and fish will be the backbone of future water management in Europe. This book describes and compares the relevant methodologies and tools, based on a large data set covering rivers in most parts of Europe. The 36 articles presented will provide scientists and water managers with a unique insight into background and application of state-of-the-art monitoring tools and techniques.

Download or read book Phage Display written by Tim Clackson and published by OUP Oxford. This book was released on 2004-03-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book is designed to enable researchers to design and undertake all aspects of a phage display project, from designing an experimental strategy and constructing a library to performing selections and analyzing the results.All of the protocols and chapters are extensively cross-referenced, allowing readers to move beyond the specific examples provided in order to customize the procedures for their own protein or selection system of interest. Phage Display is an up-to-date, comprehensive and integrated experimental guide to the technique, which is essential reading for anyone currently using, or wishing to use the technique for basic research and drug discovery.

Download or read book Biochemistry written by David E. Metzler and published by Academic Press. This book was released on 2001-03-23 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. It also features: thousands of literature references that provide introduction to current research as well as historical background; twice the number of chapters of the first edition; and each chapter contains boxes of information on topics of general interest. -- Publisher description.

Download or read book Biology of Antithrombins written by Geza Sas and published by CRC Press. This book was released on 1989-11-30 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication covers topics related to the biochemistry and clinical significance of the proteins displaying thrombin-inhibiting activity. Only in the past twenty-five years has the biological significance of proteins inhibiting blood coagulation been recognized. These inhibitors play a key role in the regulation of blood coagulation by controlling the activated serine proteinases. Certain proteins, the antithrombins, exert their effect upon thrombin leading to a reduction in the rate of fibrin formation. Important work has been done with thrombosis; chronic liver disease; disseminated intravascular coagulation; thromboembolic episodes during pregnancy, delivery; and oral contraceptive therapy. Substitution of purified, concentrated antithrombin III fractions has proven to be an effective and safe therapy for patients with antithrombin-III deficiencies. This important addition to scientific literature is of value to those of hematology, thrombosis research, transfusion technology and biochemistry.

Download or read book Food Facts And Principles written by N. Shakuntala O. Manay and published by New Age International. This book was released on 2001 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Book Deals With Foods From The Point Of View Of Cultural Practices In India. Each Food Is Discussed From The Point Of Its Production, Processing And Utilization In The Indian Context. Foods Of Special Importance In The Indian Diet Like Pulses, Spices And Nuts Are Considered At Length. The Book Gives A Comprehensive Account Of Foods And Their Products With Regard To Production, Composition, Nutritive Value, Uses And Preservation. Indigenous Food Preparations Based On Fermented Rice And Pulse, Milk And Indian Confectionery Have Been Discussed. Various Laws Issued By The Government To Control Food Quality Are Highlighted. Food Is More Than Nutrients. In Addition To Nursing Our Body And Promoting Good Health, Foods Have An Affect On Our Mind, Emotion And Spiritual Life. There Is Of Late, A Great Awareness In The Relationship Of Food And Spiritual Life. Hence, A New Chapter On Nutrition, Health And Food Consciousness Is Included In The Second Edition.

Download or read book Optical Thin Films written by James D. Rancourt and published by SPIE Press. This book was released on 1996 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical, user-oriented reference for engineers who must incorporate and specify coatings for filters, antiglare effects, polarization, or other purposes in optical or electro-optical systems design. It focuses on preparation techniques and characteristics of commercially available products and provides information needed to determine what type of filter is needed to solve a particular problem, what its limitations are, and how to care for it.

Download or read book Proteins Peptides and Amino Acids SourceBook written by John Stephen White and published by Springer Science & Business Media. This book was released on 2002-04-15 with total page 1071 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins, Pep tides and Amino Acids SourceBook is the second in a series of reference books conceived to cover the explosive growth in commercially available biological reagents. The success of our first reference work, Source Book of Enzymes published in 1997, encouraged us to continue this series. Choosing proteins, peptides, and amino acids as the subject matter for the second volume was simple, given their preeminence in regulating biochemical processes and their importance to modern molecular biology. The SourceBook series was inspired by our difficulty in locating a suitable replacement for a depleted reagent in the midst of an urgent research project. To our dismay, we found the reagent supplier out of business and the product line no longer available. Other reagent catalogs on our library bookshelf offered a narrow selection and incom plete functional information. We were ultimately able to locate a satisfactory alternative only by making countless inquiries and paging through innumerable product catalogs and technical data sheets. We needed-but could not find-a single resource that cataloged available compounds, organized them in a logical and accessible format, provided critical technical information to distinguish one from another, and told us where we could buy them.

Download or read book Protein Phosphorylation written by Grahame Hardie and published by OUP Oxford. This book was released on 1999-10-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reversible phosphorylation is one of the major mechanisms of controlling protein activity in all eukaryotic cells. This new edition of Protein Phosphorylation: A Practical Approach provides a comprehensive description of current methods used to study protein phosphorylation and the kinases and phosphatases which catalyse it. It includes protocols for studying phosphorylation in intact cells; analysis of signal transduction pathways, kinase specificity, and kinase interactions; assay and purification of kinases and phosphatases; and identification of substrates. Also covered are cloning and expression protocols and advice on the crystallization of kinases and phosphatases. Protein Phosphorylation: A Practical Approach 2e will therefore be of great value to any researcher investigating aspects of reversible protein phosphrylation.

Download or read book Fundamentals of Water Treatment Unit Processes written by David Hendricks and published by CRC Press. This book was released on 2016-04-19 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carefully designed to balance coverage of theoretical and practical principles, Fundamentals of Water Treatment Unit Processes delineates the principles that support practice, using the unit processes approach as the organizing concept. The author covers principles common to any kind of water treatment, for example, drinking water, municipal wastew

Download or read book Thermal Spray 2007 Global Coating Solutions Proceedings of the 2007 International Thermal Spray Conference written by Edited by Basil R. Marple, Margaret M. Hyland, Yuk-Chiu Lau, Chang-Jiu Li, Rogerio S. Lima, Ghislain Montavon and published by ASM International. This book was released on with total page 1246 pages. Available in PDF, EPUB and Kindle. Book excerpt: