Download or read book Subcellular Distribution and Microdosimetry Studies for Boron Neutron Capture Therapy written by Tien Nguyen and published by . This book was released on 1991 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Physics Dosimetry and Microdosimetry of Boron Neutron Capture Therapy written by Zamir Ghani and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A validated experimental and numerical procedure is described detailing macroscopic and microscopic dose calculations forming the basis of a protocol for the pre-clinical biological characterisation of the University of Birmingham's BNCT facility. Fundamental reference dosimetric measurements have been carried out at the University of Birmingham's accelerator based NCT facility and the Massachusetts Institute of Technology (MIT) research reactor to characterise macroscopic and microscopic doses and derive correction factors for the irradiation of V79 cells incubated in boric acid and irradiated as monolayers. On and off-axis thermal neutron, fast neutron and photon doses have been measured and calculated with standard macroscopic dosimetry techniques (foils and ion chambers) from which normalised MCNPX calculations are used to derive perturbation factors and off-axis corrections for cell flask irradiations. Microdosimetric correction factors are calculated for the boron dose component using Monte Carlo methods to simulate lithium ion and alpha particle tracks in semi-stochastic geometries representative of cell monolayer irradiations, incubated in a medium with 50ppm boric acid. Further simulations of recoil protons from nitrogen capture reactions allow for the calculation of correction factors for the non-uniform distribution of the nitrogen dose at the cellular level.
Download or read book Progress in Neutron Capture Therapy for Cancer written by B.J. Allen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the odds are not evenly distributed. Prognosis for some cancers is good, but for others, few patients will survive 12 months. This latter group of cancers is characterised by a proclivity to disseminate malignant cells in the host organ. The degree of surgery possible may be limited by the critical nature of the organ, and chemotherapy and radiotherapy are of palliative value only. In some cases systemic metastases occur, but in other cases, failure to achieve local control results in death. First among these cancers are the high grade brain tumours, astrocytoma 3,4 and glioblastoma multiforme. Local control of these tumours should lead to cure. Other cancers melanoma metastatic to the brain, for which a useful palliative therapy is not yet available, and pancreatic cancer for which localised control at an early stage could bring about improved prognosis. Patients with these cancers have little grounds for hope. Our primary objective is to reverse this situation with Neutron Capture Therapy (NCT). The purpose of this fourth symposium is to hasten the day whereby patients with these cancers can reasonably hope for substantial remissions. The first symposium on NCT was held in Boston in 1983, followed by Tokyo in 1985 and Bremen, Germany in 1988.
Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Download or read book International Journal of Radiation Biology written by and published by . This book was released on 1994 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1995 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.
Download or read book Transactions of the American Nuclear Society written by and published by . This book was released on 1996 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetics and Biodistribution of Boron Compounds written by Crister Ceberg and published by . This book was released on 1994 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Modern Technology of Radiation Oncology written by Jake Van Dyk and published by Medical Physics Publishing Corporation. This book was released on 1999 with total page 1106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details technology associated with radiation oncology, emphasizing design of all equipment allied with radiation treatment. Describes procedures required to implement equipment in clinical service, covering needs assessment, purchase, acceptance, and commissioning, and explains quality assurance issues. Also addresses less common and evolving technologies. For medical physicists and radiation oncologists, as well as radiation therapists, dosimetrists, and engineering technologists. Includes bandw medical images and photos of equipment. Paper edition (unseen), $145.95. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1992-04 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
Download or read book Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy written by Robert G. Zamenhof and published by . This book was released on 1994 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neutron Dosimetry written by H. G. Menzel and published by . This book was released on 1997 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book KURRI Progress Report written by Kyōto Daigaku. Genshiro Jikkenjo and published by . This book was released on 2000 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
