Download or read book Studying the healing and long term outcomes of two partial thickness wound models using different wound dressings written by Matilda Karlsson and published by Linköping University Electronic Press. This book was released on 2019-11-08 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Safe and effective wound dressing treatments are important for proper wound healing. Such procedures therefore need to be evidence-based regarding the most important outcome measures such as healing time, less discomfort for the patient, duration of hospital care and, importantly, less scarring. As the relation between longer healing times and more severe scarring is known, it is important to find dressing treatments that reduces such complications by providing fast and proper wound healing. In this thesis, four established wound dressing treatments (hydrofibre covered with film; porcine xenografts and polyurethane foam, with and without silver), were evaluated for two types of acute, partial thickness wounds: split thickness skin graft (STSG) donor sites and partial thickness burn wounds in two randomised, controlled clinical trials (RCT) with longterm scar follow ups. The relations between factors thought to influence wound healing and scarring as sex, infection, wound extent and depth, healing time and skin grafting were also investigated in these two wound models. Methods: Data from these trials were collected on sex, infection rates, wound depth and extent, need of skin grafting, healing times and scarring frequency together with demographic data. Scars were evaluated at 8 years in Study II and III and at 6 and 12 months after injury in Study V. Results: Two dressing treatments; hydrofibre covered with film and porcine xenografts gave significantly faster healing of the STSG donor sites than the standard of care (SOC) dressing, the polyurethane foam. The hydrofibre was thereafter implemented as the new SOC at the department. The long-term scar follow up showed that the hydrofibre group was most satisfied with their donor site scar, providing further evidence for the implementation of this dressing strategy. From the observer’s perspective no differences were found between these treatment groups. For partial thickness burns the treatment with a silvercontaining foam dressing showed significantly shorter healing time, whereas for the scars, no difference between dressing groups could be detected. A number of factors were identified that affected healing time: for donor sites only male sex was associated with shorter healing time. Sex was also the only factor that influenced donor site scarring, where female patients, both subjectively and objectively, were rated with higher scores (worse outcome). For partial thickness burns a larger extent of the burn wound, presence of deep dermal burns, and the need of skin grafting, all had a negative impact on both healing time and final scar. The final scar was also significantly affected by longer wound healing times and infection. Conclusion: The results suggest that the use of hydrofibre dressings covered with film on donor sites resulted in positive short-term and long-term outcomes. Regarding partial thickness burns, silver foam dressing resulted in faster healing but as for the final scar, no difference could be seen. Several factors were associated with longer healing times and more severe scarring such as: female sex, larger burns, deep dermal burns, skin grafting, and infection. Longer healing times were related to more severe scarring. Bakgrund: Säkra och effektiva förbandsbehandlingar är av stor klinisk betydelse. Därför behövs evidensbaserade sårbehandlingar med fokus på de viktigaste utfallen som läkningstid, minskning av patientens lidande, vårdtid och mindre ärrbildning. Eftersom förhållandet mellan längre läkningstid och mer allvarlig ärrbildning är känt är det viktigt att hitta sårbehandlingar som minskar komplikationer, ger snabb läkning av såret och acceptabla ärr. I denna avhandling utvärderades etablerade sårbehandlingar (hydrofiber täckt med film, xenotransplantat från gris och polyurethanskumsförband, med och utan silver), för två typer av akuta delhudskador; tagställen för delhudstransplantatet och dermala brännskador, i två randomiserade kontrollerade kliniska studier. Förhållandet mellan påverkansfaktorer såsom kön, infektion, sårdjup, såromfattning, läkningstid och hudtransplantation och utfall för läknings- och ärresultat har också undersökts. Metoder: Data för kön, infektionsfrekvens, sårdjup och omfattning, behov av hudtransplantat, läkningstid och ärrbildning från två randomiserade kontrollerade studier samlades in tillsammans med demografisk data. Ärren utvärderades efter 8 år i studie II och III samt vid 6 och 12 månader efter skada i studie V. Resultat: Två sårbehandlingar; hydrofiber täckt med film och xenotransplantat från gris visade signifikant snabbare reepitalisering av tagställen än standardförbandet (polyuretanskum). Hydrofibern implementerades som den nya standardbehandlingen på kliniken. Den långsiktiga ärruppföljningen avslöjade att gruppen med hydrofiber var den mest nöjda med sina tagställes-ärr, vilket gav ytterligare styrka till genomförandet av behandlingen. Ur observatörsperspektivet hittades inga skillnader mellan dessa grupper. För dermala brännskador gav behandlingen med silverinnehållande skumförband signifikant bättre läkningsresultat, för ärrbildning upptäcktes inte någon skillnad mellan grupperna. Ett antal faktorer som påverkade läkningstider identifierades; för tagställen gav endast manligt kön kortare läkningstider. Kön var också den enda faktorn som påverkade tagställets ärrresultat där kvinnor, både subjektivt och objektivt, bedömdes med högre poäng (sämre utfall). För dermala brännskador var det faktorer såsom en större omfattning av brännskadorna, närvaron av djupa dermala brännskador och behovet av hudtransplantation som hade negativ påverkan på både läkningstider och slutliga ärr-resultat. Det slutliga ärrutfallet påverkades också signifikant av längre läkningstider och infektion. Konklusion: Data tyder på att användningen av hydrofiber täckt med film på tagställen gav positiva resultat både på kort- och lång sikt. När det gäller förband för dermala brännskador resulterade silverskumförband i snabbare läkning men vad gäller ärr kunde ingen skillnad hittas. Flera faktorer var relaterade till längre läkningstider och mer ärrbildning som kvinnligt kön, större omfattning av brännskador, djupa dermala brännskador, hudtransplantation och infektion. Längre läkningstider var relaterat till mer allvarlig ärrbildning.
Download or read book Bioengineered Skin Substitutes for the Management of Burns written by C.T. Pham and published by . This book was released on 2006 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Wounds Wound Dressings and Wound Healing written by Melvin A. Shiffman and published by Springer Nature. This book was released on 2020-08-04 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses wound care in vascular surgery, neurosurgery and lower extremity ulcers, while also providing detailed information on the latest concepts in antimicrobial therapy. The book presents essential content on the assessment, care, measurement and repair of wounds, and describes important scientific aspects as well as current clinical techniques. Due to the various topics covered, the book offers a valuable resource not only for plastic surgeons, but also for neurosurgeons, vascular surgeons and all clinicians who are interested in learning about current antimicrobial agents and their use.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Acute and Chronic Wounds written by Ruth Bryant and published by Elsevier Health Sciences. This book was released on 2015-11-24 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prevent and manage wounds with this expert, all-inclusive resource! Acute & Chronic Wounds: Current Management Concepts, 5th Edition provides the latest diagnostic and treatment guidelines to help you provide quality care for patients with wounds. This textbook presents an interprofessional approach to maintaining skin integrity and managing the numerous types of skin damage including topics that range from the physiology of wound healing, general principles of wound management, vulnerable patient populations, management of percutaneous tubes, and specific care instructions to program development. Written by respected nursing educators Ruth Bryant and Denise Nix, this bestselling reference also provides excellent preparation for all wound certification exams. A comprehensive approach to the care of patients with acute and chronic wounds guides students and health care providers to design, deliver and evaluate quality skin and wound care in a systematic fashion; the comprehensive approach includes the latest advances in diagnosis, differentiation of wound types, nutrition, prevention, treatment, and pharmacology. Self-assessment questions and answers in each chapter help you assess your knowledge and prepare for all wound certification exams. Checklists offer a concise, easy-to-read summary of the steps needed to achieve the best patient care outcomes. Risk assessment scales help in determining a patient's risk for developing a wound, and wound classification tools identify the proper terminology to be used in documentation. Learning objectives at the beginning of each chapter focus your study on the most important content. Principles for practice development boost outcomes and productivity in agencies and institutions, home care, acute care, long-term care, and long-term acute care settings. NEW coverage includes the latest guidelines from WOCN, AAWC, NPUAP, EPUAP, and PPPIA, and the American College of Physicians. New sections cover the prevention and management of biofilm, the new skin tear classification system, MASD and MARCI, CTP terminology and classification scheme, and integration of the Health Belief Model. NEW! Additional full-color photographs show the differential diagnosis of types of skin damage, management of fistulas, and NPWT procedures. NEW! Clinical Consult features help in applying concepts to clinical practice, showing students and health care professionals how to assess, manage, and document real-life patient and staff encounters using the ADPIE framework. NEW two-color illustrations and design make the book more visually appealing.
Download or read book Guided Regeneration of the Human Skin written by Erika Nyman and published by Linköping University Electronic Press. This book was released on 2015-03-17 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day and in all parts of the world, humans experience different grades of wounding and tissue loss of the skin, thus initiating one of the most complex biological processes. Acute and chronic wounds, as well as the additional problem of skin scarring, involve not only great suffering for the patient but also extensive health care costs for the society. Although the wound-healing process is a wellstudied field much knowledge must be gained to unlock the door to regenerative pathways in humans. Epidermis heals by complete regeneration, but dermal and full thickness injuries heal with fibrosis and scar formation. In Papers I and II, we studied whether dermal scarring could be turned into regeneration by using two different types of threedimensional dermal scaffolds. In Paper I, we studied a solid scaffold made of poly(urethane urea), initially in vitro then followed by in vivo studies. In Paper II, we intradermally injected a liquid three-dimensional scaffold consisting of porous gelatin spheres in human healthy volunteers. Both materials showed ingrowth of functional fibroblasts and blood vessels and appeared to stimulate regeneration while slowly degrading. This finding could be of significant clinical importance, for example in burn wound care or after cancer surgery. In Papers III and IV, we wanted to study the effects of amniotic fluid and hyaluronic acid on adult wound healing, because early fetal wounds re-epithelialize rapidly and naturally heal dermis by regeneration without the need of a dermal scaffold. Amniotic fluid, naturally rich in hyaluronic acid, induced an accelerated reepithelialization of adult human wounds in vitro, and hyaluronic acid seemed to be important for this effect. Stimulation with exogenous hyaluronic acid in vivo induced accelerated re-epithelialization and an altered protein expression in healthy human volunteers. The inflammatory phase of wound healing, as measured by tissue viability imaging, was not affected by hyaluronic acid. Elucidating the effects of amniotic fluid and hyaluronic acid on the wound-healing process may allow improved treatment of wounds with impaired healing. Studies on finding new dermal scaffolds and studies on the positive effect of amniotic fluid or hyaluronic acid on the wound-healing process are two different ways of gaining insight that may lead to regeneration and improved wound healing for the patient.
Download or read book Dermal Influence on Epidermal Resurfacing During the Repair of Split Thickness Wounds written by Patrica A. Hebda and published by . This book was released on 1986 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this study was evaluate dermal-epidermal interrelationships during wound repair by assessing the effect on wound healing factors derived from platelets. Two methods were used to approach the problem: 1) an in vitro epithelization model in which small sections of partial-thickness pig skin (explants) were grown in medium containing fetal bovine serum and/or a platelet homogenate or purified-thickness platelet-derived factors, a nd eipidermal cell outgrowth from the explants was measured; 2) a wound healing animal model in which partial-thickness on epidermal cells. Our conclusions are that platelet components stimulate epidermal cell viability and outgrowth in explant cultures. We recommend further exploration of these factors. The factors should be purified from platelets, compared with known growth factors, and evaluated first in vitro with epidermal explant and cell culture systems. Active factors should be tested alone and in combination in animal would healing trails. Finally, an effective treatment should be evaluated in a clinical study with human subjects for effects on acute wounds, burn wounds and chronic ulcers.
Download or read book Fragility Fracture Nursing written by Karen Hertz and published by Springer. This book was released on 2018-06-15 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book aims to provide a comprehensive but practical overview of the knowledge required for the assessment and management of the older adult with or at risk of fragility fracture. It considers this from the perspectives of all of the settings in which this group of patients receive nursing care. Globally, a fragility fracture is estimated to occur every 3 seconds. This amounts to 25 000 fractures per day or 9 million per year. The financial costs are reported to be: 32 billion EUR per year in Europe and 20 billon USD in the United States. As the population of China ages, the cost of hip fracture care there is likely to reach 1.25 billion USD by 2020 and 265 billion by 2050 (International Osteoporosis Foundation 2016). Consequently, the need for nursing for patients with fragility fracture across the world is immense. Fragility fracture is one of the foremost challenges for health care providers, and the impact of each one of those expected 9 million hip fractures is significant pain, disability, reduced quality of life, loss of independence and decreased life expectancy. There is a need for coordinated, multi-disciplinary models of care for secondary fracture prevention based on the increasing evidence that such models make a difference. There is also a need to promote and facilitate high quality, evidence-based effective care to those who suffer a fragility fracture with a focus on the best outcomes for recovery, rehabilitation and secondary prevention of further fracture. The care community has to understand better the experience of fragility fracture from the perspective of the patient so that direct improvements in care can be based on the perspectives of the users. This book supports these needs by providing a comprehensive approach to nursing practice in fragility fracture care.
Download or read book A Brief History of Wound Healing written by and published by . This book was released on 1998 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acute Chronic Wounds written by Ruth A. Bryant and published by Elsevier Health Sciences. This book was released on 2012-01-01 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rev. ed. of: Acute and chronic wounds / [edited by] Ruth A. Bryant, Denise P. Nix. 3rd ed. c2007.
Download or read book Patient Safety and Quality written by Ronda Hughes and published by Department of Health and Human Services. This book was released on 2008 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nurses play a vital role in improving the safety and quality of patient car -- not only in the hospital or ambulatory treatment facility, but also of community-based care and the care performed by family members. Nurses need know what proven techniques and interventions they can use to enhance patient outcomes. To address this need, the Agency for Healthcare Research and Quality (AHRQ), with additional funding from the Robert Wood Johnson Foundation, has prepared this comprehensive, 1,400-page, handbook for nurses on patient safety and quality -- Patient Safety and Quality: An Evidence-Based Handbook for Nurses. (AHRQ Publication No. 08-0043)." - online AHRQ blurb, http://www.ahrq.gov/qual/nurseshdbk/
Download or read book Skin and Wound Care written by Cathy Thomas Hess and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely updated for its Sixth Edition, this handbook is the only all-in-one portable guide to skin and wound care, with new chapters on skin care and incontinence, important new information on regulations, and more than 650 dressings, drugs, and other products for every type of wound. Part I provides detailed guidelines on wound care and prevention and related professional and legal issues. Part II features profiles and photographs of over 300 wound care products. Part III contains charts of over 300 additional products. Appendices include assessment tools and multiple treatment algorithms. A manufacturer resource guide with Website listings is included.
Download or read book Advanced Wound Repair Therapies written by David Farrar and published by Elsevier. This book was released on 2011-06-21 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. - Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds - Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing - Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair
Download or read book Therapeutic Dressings and Wound Healing Applications written by Joshua Boateng and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest research on techniques for effective healing of chronic and difficult to heal wounds The healing of chronic wounds is a global medical concern, specifically for patients suffering from obesity and type II diabetes. Therapeutic Dressing and Wound Healing Applications is an essential text for research labs, industry professionals, and general clinical practitioners that want to make the shift towards advanced therapeutic dressing and groundbreaking wound application for better healing. This book takes a clinical and scientific approach to wound healing, and includes recent case studies to highlight key points and areas of improvement. It is divided into two key sections that include insight into the biochemical basis of wounds, as well as techniques and recent advancements. Chapters include information on: ● Debridement and disinfection properties of wound dressing ● Biofilms, silver nanoparticles, and honey dressings ● Clinical perspectives for treating diabetic wounds ● Treating mixed infections ● Wound healing and tissue regeneration treatments ● Gene based therapy, 3D bioprinting and freeze-dried wafers Anyone looking to update and improve the treatment of chronic wounds for patients will find the latest pertinent information in Therapeutic Dressing and Wound Healing Applications.
Download or read book Oral Wound Healing written by Hannu Larjava and published by John Wiley & Sons. This book was released on 2012-05-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing.An essential synthesis of current research and clinical applications, Oral Wound Healing will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researchers in oral medicine and biology.
Download or read book Wound Care written by Carrie Sussman and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for health care professionals in multiple disciplines and clinical settings, this comprehensive, evidence-based wound care text provides basic and advanced information on wound healing and therapies and emphasizes clinical decision-making. The text integrates the latest scientific findings with principles of good wound care and provides a complete set of current, evidence-based practices. This edition features a new chapter on wound pain management and a chapter showing how to use negative pressure therapy on many types of hard-to-heal wounds. Technological advances covered include ultrasound for wound debridement, laser treatments, and a single-patient-use disposable device for delivering pulsed radio frequency.
Download or read book Product Guide to Skin Wound Care written by Cathy Hess and published by Lippincott Williams & Wilkins. This book was released on 2019-11-04 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Choose the best possible skin and wound care products to support your patients’ skin health and wound healing, with the invaluable Product Guide to Skin and Wound Care, 8th Edition. Listing 294 products in alphabetical order, this handy product guide for wound care practitioners across all practice settings offers detailed information—sizes, action, indications, contraindications, application, and removal information—so that your choices stay informed and accurate.
