Download or read book Study of Biological Activities of Novel Quinazoline Derivatives written by Ganguli Subarna and published by LAP Lambert Academic Publishing. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quinazolines are the derivatives of benzopyrimidine ring system. It is known and well documented in the literature that there exists a connection between wide spectrums of biological activities with the molecules having quinazoline moiety . Hence quinazoline-4(3H)-one is a lead compound for designing potential bioactive agents. Quinazoline derivatives possess a variety of activities like antibacterial, antifungal, anti-HIV, anthelmintic, CNS depressant and antitubercular . Synthesis of naturally occurring bioactive alkaloid having quinazolone system, vascinone is reported recently . Qunazolines possess antimalarial activity. Due to various types of biological activity found in Quinazoline derivative objective has been taken to synthesise Quinazoline derivatives in order to evaluate their various biological activity such as antibacterial, antifungal, antimalarial, and hypolipidemic activities.
Download or read book Quinazolinone and Quinazoline Derivatives written by Ali Gamal Al-kaf and published by BoD – Books on Demand. This book was released on 2020-05-06 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the problems with modern public health is target searching for new highly effective medicinal preparations. Among those medicinal preparations are the natural and synthetic origins of quinazolinone-4 derivatives. Quinazolinone derivatives are reported to be physiologically and pharmacologically active. They also exhibit a wide range of activities such as anticonvulsant, antiinflammatory, antifungal, antimalarial, and sedative properties. Some of these compounds are identified as drugs used as diuretics, vasodilators, and antihypertensive agents. Moreover, sulfonamide derivatives have been widely used as bacteriostatic agents. Prompted by the above-mentioned facts and in conjunction with our ongoing program on the utility of readily obtainable starting material for the synthesis of heterocyclic systems of biological interest, we have decided to synthesize a series of quinazolinone derivatives having sulfonamide moiety with a potentially wide spectrum of biological responses.
Download or read book Some Studies on Heterocyclic Compounds written by Gor Deepa and published by LAP Lambert Academic Publishing. This book was released on 2015-12-08 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years researchers are very much interested in the chemistry of heterocyclic compounds due to the wide range of their industrial applications in the area of organic chemistry. This book contains the synthesis, characterization and biological investigations of heterocyclic compounds: Azetidinone and 4-Thiazolidinone. This book introduces the methods of preparation on quinazoline and Schiff bases. It discusses at length the procedures of preparation of Azetidinone and 4-Thiazolidinone. Antimicrobial activities and NMR and IR spectroscopy of both of them are also discussed. This book will be immensely helpful for researchers and young research scholars to have a good source of reference for their work. Industry practitioners will find the results and discussions of this book very helpful in their routine tasks. Several methods of direct implementation of this work in large scale R & D projects are also discussed.
Download or read book Recent Advances on Quinazoline written by Ali Gamal Al-Kaf and published by BoD – Books on Demand. This book was released on 2024-03-20 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates and identifies novel therapeutic compounds for the treatment of a range of illnesses. Heterocyclic compounds are a significant class of substances with biological activity. Among them, quinazoline has attracted a lot of interest because of its important biological properties. Numerous compounds with quinazoline moiety have been shown to exhibit a wide range of therapeutic properties, including antioxidant, antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, and antibacterial activities. This book presents a comprehensive overview of quinazoline and its derivatives. The chapters address recent advances in the synthesis of several different heterocyclic compounds, the use of computational studies for finding new active quinazoline derivatives, the biological activities of quinazoline, and much more.
Download or read book Significant Pharmaceuticals Reported in US Patents written by Thomas F. DeRosa and published by Elsevier. This book was released on 2010-07-07 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications. Identifies next generation pharmaceuticals Provides practical preparation methods for each active agent and derivatives Documents the analytical characterization and biological testing results of active agents
Download or read book Alkaloids written by S. William Pelletier and published by . This book was released on 1983 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A REVIEW ON QUINAZOLINE HETEROCYCLES written by Dr. Biswajit Dash and published by Booksclinic Publishing. This book was released on 2021-01-07 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The review on Quinazoline Heterocycle: A Pharmacophoric Scaffold book has been written, keeping in view the needs and interest of student, teachers and researchers in pharmaceutical Science field. The prime aim and objective of the authors has always been to keep transparency in the subject matter, the various terminologies and texts which have been introduced and defined in a precise and articulate manner. Besides this the entire text has been substantiated with the chemical structure of synthesized Quinazoline derivatives and their pharmacological significance. All the authors communicate their interest of the subject matter by reviewing through various literatures. This book appears to be blend of synthesis, physico-chemical characterisation and pharmacological activity of various Quinazoline derivatives synthesized by different scientists. Heterocyclic compounds have broad spectrum of application in the field of medicinal chemistry due to potent pharmacological activity which has been recognized and has been studied experimentally. Quinazoline and its derivatives have received considerable attention due to their synthetic and effective biological importance. The connection between a wide spectrum of biological activities and compounds containing quinazoline moiety has been known and it clearly demonstrate the remarkable potential of quinazoline derivatives as source of useful pharmacophore for the new drug discovery. This book is about several structural modifications on the quinazoline nucleus which were done by different scientists to evaluate the enhancement in the biological activities like anti-convulsant, CNS depressant, anti-microbial, analgesic and anti-inflammatory, anti-tubercular, anti-cancer, anti-HIV activity. Any constructive criticism, comments and suggestions for further improvement from the readers are always welcome. We wish to thank the publishers for showing the interest by them for publication. The authors acknowledge the help and excellent co-operation from editors of Books Clinic publications for bringing out this book in a record time frame. "
Download or read book Handbook of Phase Transfer Catalysis written by Y. Sasson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase transfer catalysis is a sophisticated chemical technique which can be used to perform a variety of chemical reactions under mild conditions and with improved control. Since the concept was developed, both the theoretical and practical synthetic applications have seen considerable development, to the point where the technique can be applied to many areas of chemistry. Thus, phase transfer methods are now utilized in many applications, from research chemistry to full-scale production, where the benefits of faster, cleaner and more selective reactions are required. In this new book, the editors have brought together a range of contributors, each of whom is working at the forefront of the technology, to provide a clear, concise and ahtoritative review of this important area of chemistry. Industrial and academic chemists working on the synthesis, scale-up, production or analysis of a wide range of chemical products will find this book an essential reference on phase transfer technology.
Download or read book Quinazolinone and Quinazoline Derivatives written by Satyendra Mishra and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery and optimization comprise one of the most significant targets in medicinal chemistry. Quinazoline and quinazolinone derivatives and nitrogen-containing heterocycles have received significant attention due to their widely and distinct biopharmaceutical activities. Quinazolines and quinazolinones are considered as noteworthy chemical for the synthesis of diverse physiological significance and pharmacological utilized molecules. Quinazolines are building blocks for about 150 naturally occurring alkaloids with a broad range of biological activity. The various substituted quinazolines and quinazolinones displayed important, for example, sedative hypnotics, antibacterial, anti-inflammatory, analgesic, antipsychotic, antifungal, antimalarial, anticonvulsant, anti-Parkinsonism, cancer, and other activities. This chapter aims to highlight the latest evidence of quinazolinone and quinazoline derivatives as a privileged scaffold in medicinal chemistry.
Download or read book Quinazolines Synthesis Characterization and Biological Properties written by Dr. Nripendra Singh and published by InfoCapsule LLP. This book was released on 2022-12-15 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is for the Under Graduate, Post Graduate Level Students (viz. Organic Chemistry, Pharmaceutical Chemistry, and B. Pharm. M. Pharm) and Research / Doctoral Level Students. Also, this book will be useful for researcher in the field of Organic Chemistry, Medicinal Chemistry, especially in the area of Synthetic Chemistry.
Download or read book Environment Friendly Antiviral Agents for Plants written by Baoan Song and published by Springer Science & Business Media. This book was released on 2011-01-26 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant virus disease is a worldwide threat to agriculture. Environment-Friendly Antiviral Agents for Plants systematically describes the basic theory, new ideas, and new methods to discover novel antiviral agents through research on plant immune activation. The cutting-edge research methodology, technology and progress on novel antiviral agent innovation are systematically described. With abundant illustrations and figures, the book is intended for researchers and practitioners in the fields of pesticide science, plant protection, organic chemistry, fine chemicals, applied chemistry, environment chemistry and agriculture science. Dr. Baoan Song and Dr. Song Yang are professors at the Center for R&D of Fine Chemicals, Guizhou University, China; Mr. Linhong Jin and Dr. Pinaki S. Bhadury are associate professors there.
Download or read book Importance of Quinazoline Against Cancer Microbial Infection written by Theivendren Panneer Selvam and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Review is a major component to carry out the research work. The review on quinazoline, substituted amine, semicarbazide derivatives furnishes its established biological activities. Thus quinazoline scaffold is not only synthetically important but also possesses a wide range of promising biological activities. Future investigations of this scaffold could give some more encouraging results. The selected review on quinazoline and fused quinazoline derivatives and its anticancer, antimicrobial activities are initiative to researchers those who involved in the medicinal chemistry research
Download or read book Alternative Energy Sources for Green Chemistry written by Georgios Stefanidis and published by Royal Society of Chemistry. This book was released on 2016-08-24 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of alternative energy forms and transfer mechanisms is one of the key approaches of process intensification. In recent years, significant amounts of research have been carried out in developing chemical processing technologies enhanced by plasma, electric and magnetic fields, electromagnetic and ultra-sound waves and high gravity fields. Discussing the broad impact of alternative energy transfer technologies on reactions, separations and materials synthesis, this book reports on recent breakthrough results in various application areas. It provides a comprehensive overview of the current developments in the field. The book enables industrialists, academics and postgraduates in alternative-energy based processing to see the potential of alternative energies for green chemistry and sustainability of chemical manufacturing.
Download or read book Quinazolines written by Savita Dhongade-Desai and published by LAP Lambert Academic Publishing. This book was released on 2014-06-09 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quinazoline derivatives are of special importance because of their versatile biological and pharmacological activities especially anti-inflammatory, anticonvulsant, hypnotic, anthelmentic, hypotensive, antibacterial agents etc. Microwave irradiation using scientific ovens has been rapidly increased for the variety of reactions such as synthesis of heterocycles due to reduction in reaction time, improved energy utilization, potential for lower processing temperature and improved product uniformity. Alkylation & condensations are carried out with the said technique successfully in the present work. The synthesis of number of different quinazoline derivatives has been successfully carried out with the said technique. The structures were confirmed on the basis of IR and PMR spectral data. The structural formulae when subjected to computer programme PASS, prediction results are obtained for the synthesized compounds. This has been reported in the present book. The content in the books is highly significant for the researchers and students of synthetic organic chemistry, heterocyclic, pharmaceutical, medicinal chemistry as well as computational and combinatorial chemistry.
Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Download or read book Green Chemistry Synthesis of Bioactive Heterocycles written by K. L. Ameta and published by Springer. This book was released on 2014-06-17 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.
Download or read book Mechanism of Action of Antimicrobial and Antitumor Agents written by J. F. Snell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.
