Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Studies with Temperature sensitive Mutants of Herpes Simplex Virus Type 2 written by José Esparza-Bracho and published by . This book was released on 1974 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Herpes Simplex Virus written by Barry T. Rouse and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although upstaged by the tragic appearance of the human immunodeficiency virus, herpes simplex viruses (HSV) types 1 and 2 continue to be major human pathogens against which we lack acceptable vaccines or other means of immunological control. The virus is large and complex, coding for 70 or more proteins. Although many mysteries remain to be unraveled, our knowledge base regarding genomic organization, gene expression and regulation, pathogenesis, and immune recog nition of component parts is quite considerable. Indeed, meet ings devoted entirely to herpesviruses are conspicuous by their frequency and excellent, yet sometimes exclusive, attendance. The purpose of this volume is to compile in a single book a series of reviews by leading investigators that deal with various aspects of virus-host interactions and which hopefully will pro vide clues as to how to best manage HSV from an immunobio logical perspective. Ultimately, one anticipates that a full under standing of virus-host interaction will lead to strategies useful for the prevention and control of HSV. The state of current progress with conventional vaccines is presented, as is a chapter on intracellular immunization. This latter novel approach to virus infections comes at approximately the bicentenary of Jenner's introduction of a successful conventional immunization strategy.
Download or read book Current Topics in Microbiology and Immunology Ergebnisse der Mikrobiologie und Immunit tsforschung written by W. Arber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1974 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Bibliography of Epidemiology written by and published by . This book was released on 1972 with total page 1302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Survey of Research on Sexually Transmitted Diseases written by and published by . This book was released on 1983 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oncology Overview written by and published by . This book was released on 1982 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Topics in Microbiology and Immunology written by W. Arber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carcinogenesis Abstracts written by and published by . This book was released on 1975 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book IARC Scientific Publications written by International Agency for Research on Cancer and published by . This book was released on 1978 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation and Genetics written by H. Fraenkel-Conrat and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: The time seems ripe for a critical compendum of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
Download or read book Contemporary Topics in Immunobiology written by Michael Hanna and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been suspected, and recently confirmed, that there is an etiologic relationship between several viruses and naturally occurring neoplasias. Virus precursors in the form of nucleic acids or antigens have consistently been associated with certain neoplasias. However, the role of these virus-specified precursors in etiology remains obscure. Recent studies of virus-associated neo plasias have led to advances in molecular techniques, which have yielded increas ingly sensitive assays for detection of virus-specific nucleic acids, and which have enabled the disruption of virus particles without concomitant loss in antigenicity of the components. These procedures have, in turn, resulted in molecular probes that allow more definitive evaluation of the host response to its virus and to the tumor cell with which the virus or its precursors are associated. Evaluations of the immune response and status of the host have provided important informa tion about carcinogenesis and the tools for seroepidemiological studies of a variety of cancers. These seroepidemiological studies have demonstrated that several human cancers, e. g. , Burkitt's lymphoma and nasopharyngeal carcinoma, are probably virus-induced, and that antibodies that are diagnostic and prog nostic for these diseases are detectable. The conclusion that feline leukemia is a disease transmitted horizontally by a virus resulted primarily from immunologi cal experiments.
Download or read book Interferon Bibliography from MEDLARS written by and published by . This book was released on 1973 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interferon and Antiviral Substances Bibliography from MEDLARS written by and published by . This book was released on 1979 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oncogenesis and Herpesviruses II Biochemistry of viral replication and in vitro transformation written by and published by . This book was released on 1975 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease written by A. Graham Pockley and published by Springer Science & Business Media. This book was released on 2009-11-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.
