Download or read book Studies Towards the Synthesis of the Antibiotic Lactonamycin written by Lee Walsh and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward a Total Synthesis of Lactonamycin written by Lewis Preece and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Work was undertaken towards the synthesis of the promising antibiotic lactonamycin (iii). Following the work of Parsons et al. it was proposed that cyclisation of the ene-diyne (i) would give access to advanced pentacyclic intermediate (ii) and that from this a total synthesis of lactonamycin would be achieved (scheme I). Scheme I : Proposed Parsons, Board, Waters cyclisation to form the pentacycle (iii)(For image refer to pdf). A synthesis towards the cyclisation precursor (i) was carried out and a route to the key tetrasubstituted phthalide (v) established. Further chemistry was proposed to complete the synthesis of lactonamycin (scheme II). Scheme II : Formation of a fully substituted benzolactone.(For image refer to pdf). During attempts to introduce the [beta]-bromoallyl group of key intermediate (v) using a high temperature Claisen rearrangement it was established that the benzodioxin (vii) underwent thermolysis to generate the reactive quinone methide intermediate (viii) and that in the presence of a nucleophilic solvent the adduct (ix) was formed (scheme III). Model studies showed the reaction to be both general and high-yielding. Scheme III : Novel quinone methide methodology. (For image refer to pdf).
Download or read book Studies Towards the Total Synthesis of Lactonamycin written by Johnathan Board and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of the CDEF Ring System of Lactonamycin written by Ronan Le Vézouet and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis of Lactonamycin written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Total Synthesis of Lactonamycin written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis of Sch 49 210 and Everninomicin Antibiotic 13 384 1 written by Scott Robert Conley and published by . This book was released on 1997 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of Medermycin written by Timothy James Brenstrum and published by . This book was released on 1999 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Lactam Antibiotics written by Alle Bruggink and published by Springer Science & Business Media. This book was released on 2001-06-30 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Download or read book Towards the Total Synthesis of Lactonamycin written by Sylvain Michel Matthieu Arthur Jacques and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of Paulomycin and Its Analogue written by Andrew Owen Donaldson Cruickshank and published by . This book was released on 1998 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent Progress in the Chemical Synthesis of Antibiotics written by Gabor Lukacs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.
Download or read book Studies Towards the Synthesis of the Aminopolyol Antibiotic Zwittermicin A written by Nina A. Dobrovinskaya and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of Anthracycline Anticancer Antibiotics written by Martin Phillip Hill and published by . This book was released on 1990 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of the Aminopolyol Antibiotic Zwittermicin A written by Nina A. Dobrovinskaya and published by . This book was released on 2007 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Directed Towards the Total Synthesis of Macrolide Antibiotics written by Charles Tweedt Buse and published by . This book was released on 1978 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis of the Antibiotic Bu 2313 B and a Bu 2313 Streptolydigin Hybrid written by Claudio Bomio-Confaglia and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
