Download or read book Studies Towards the Total Synthesis of Colchicine written by and published by . This book was released on 1995 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards a Total Synthesis of Colchicine written by and published by . This book was released on 2003 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Toward the Total Synthesis of a Colchicine Analog written by Jacob Shya Tou and published by . This book was released on 1977 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Total Synthesis of Colchicine written by Jack Zanos Gougoutas and published by . This book was released on 1964 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Cochinchistemonine written by Jean Tassel and published by . This book was released on 2011 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards the Total Synthesis of Lancifodilactone G written by Sanil Sreekumar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilactone G and concludes with a retrosynthetic analysis proposed by the Evans group, which includes a biosynthetically inspired single-pot polycyclisation reaction. Chapter 2 describes the highly stereocontrolled synthesis of the eastern fragment (F-G rings) using transition metal-mediated Pauson-Khand reaction. This chapter also reviews the metal-mediated diastereoselective Pauson-Khand reaction directed by the stereogenic centre at C2, with the ample illustration to total synthesis. Attempted strategies for the assembly of the bicyclic cyclopentanone motif via a dienyl Pauson-Khand reaction of silicon- and oxygen- tethered diene-enes are presented. The failure of these strategies at different stages of the synthesis resulted in the exploration of a classical Pauson-Khand approach, which successfully furnished the eastern fragment. Finally, a second-generation synthesis is described which provided the fully functionalised eastern fragment with improved efficiency and overall yield. Chapter 3 discusses the successful synthesis of the western fragment (B-C rings) using a diastereoselective [4+3] cycloaddition strategy. Attempted strategies for the synthesis of the key 2,3-disubstituted furan derivative are presented, which was achieved via a hetero Pauson- Khand reaction. This chapter includes a brief account of the classical [4+3] cycloaddition reactions of furans using an in situ generated oxyallyl cation and also employing vinyl carbenoids in the metal-catalysed version. The review also highlights the application of the [4+ 3] cycloaddition reaction in the expeditious assembly of functionalised 7-membered rings that occur in a number of important biologically active natural products. The third chapter goes on to describe the application of these cycloaddition reactions in the synthesis of the fully functionalised western fragment of Lancifodilactone G. Chapter 4 describes a model study aimed at expediting the synthesis of the western fragment using a rhodium-catalysed allylic substitution reaction. A brief mechanistic discussion on unique aspects of the allylic alkylation reaction is illustrated. Chapter 4 concludes by outlining the coupling strategy for eastern and western fragments and the end game studies for the completion of the synthesis of lancifodilactone G.

Download or read book Studies Towards the Total Synthesis of Ficellomycin written by and published by . This book was released on 2008 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Colchicine written by Thomas Ancrum Spencer and published by . This book was released on 1960 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Toward the Total Synthesis of Calyculin A written by Samuel William Gerritz and published by . This book was released on 1993 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Ristocetin A and Orienticin C Aglycones written by Diana V. Ciurea and published by . This book was released on 2008 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Cylindricines A and B written by Julie Elizabeth Fields and published by . This book was released on 1999 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Heteroclitin F and Taiwanschirin A B C and D written by Maxwell Brian Haughey and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Spiroquinazoline written by Siyuan Chen (Ph.D.) and published by . This book was released on 2007 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Toward the Total Synthesis of chartelline C and platensimycin written by Evan Adam Hecker and published by . This book was released on 2008 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herein is described our work towards the total synthesis of the marine natural product (")-chartelline C and the potent antibiotic ( - )-platensimycin. Part 1 relates the (")-chartelline C project. The first chapter reviews (")-chartelline C's isolation, biogeneity, and previously reported studies relevant to the area. Chapter 2 tells of our contributions including the development of a convergent, regioselective assembly of an indole-imidazole compound en route to the natural product. Chapter 3 includes the experimental details of this work and the characterization of previously unreported compounds. Part 2 recounts the ( - )-platensimycin research project. Chapter 4 discusses the importance of the natural product and the relevant previous research reported. Chapter 5 describes our efforts in this area, culminating in the stereoselective synthesis of an intermediate closely related to a known compound, which was converted to the natural product. Chapter 6 includes the experimental details of this work and the characterization of previously unreported compounds.

Download or read book Studies Toward the Total Synthesis of Quartromicin written by Jun Qi and published by . This book was released on 2006 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: The quartromicins are a group of structurally complex macrocyclic natural products that display activity against herpes simplex virus type 1 (HSV-1), influenza, and HIV. The quartromicins contain four spirotetronate subunits (two endo and two exo spirotetronates) connected in an alternating head to tail manner. While previous synthetic studies in the Roush laboratory have led to the development of an efficient pathway to the endo spirotetronate subunits, the synthesis of the exo spirotetronate subunits has remained much more challenging.

Download or read book Studies Towards the Total Synthesis of 6 7 dideoxysqualestatin written by Hamed H. Al Mamari and published by . This book was released on 2006 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis Or Ouabain written by Grazia Piizzi, 1970- and published by . This book was released on 2004 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: