Download or read book Studies Toward Synthesis of Lasonolide A Total Synthesis and Structural Determination of Dispongin A and B written by Kailas Bhalchandra Sawant and published by . This book was released on 2007 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Directed Toward the Synthesis of the B Ring of Lasonolide A written by James Paul Unch and published by . This book was released on 2002 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis and Structure Determination of Leiodelide A written by Mathieu François Chellat and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The C1-C7 southern subunit was rapidly assembled via an aldol reaction using Davies' SuperQuat auxiliary followed by Horner-Wadsworth-Emmons olefination in a three-step protecting group free synthesis.
Download or read book Studies Towards the Total Synthesis and Structural Elucidation of Leiodolide A written by Katy M. Mould and published by . This book was released on 2013 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis and Structural Elucidation of Leiodolide A written by and published by . This book was released on 2015 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of amphidinolide W and Efforts Toward Total Synthesis of lasonolide A written by Gangli Gong and published by . This book was released on 2005 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Total Synthesis of laulimalide and Efforts Toward the Total Synthesis of lasonolide A written by Matthew G. Stanton and published by . This book was released on 2003 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Application of the Prins Cyclization to a Synthesis of the Tetrahydropyran Rings of Lasonolide A written by Ruth Figueroa and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: This thesis describes studies toward the synthesis of the tetrahydropyran-containing marine macrolide lasonolide A.A summary of studies done by Lee and coworkers, that led to a revision of the structure as well as its first total synthesis is presented. This is followed by a literature review of the partial and completed syntheses of lasonolide A reported by other groups. The studies presented are based on the use of a Prins cyclization as the key reaction. The cyclization uses vinylogous carbonates as the source to generate the oxocarbenium ion. Therefore, we first introduce the background that led to the development of this reaction. The Prins cyclizations were promoted using trifluoroacetic acid and the products were immediately hydrolyzed to afford in most of the cases the tetrahydropyran rings as the major product. The cyclization of alkyne derived vinylogous carbonates resulted in instability of the product to the reaction conditions. Also, formation of 5-membered ring was a competing pathway. Vinlogous carbonates derived from Z-alkenes gave the all cis-2,3,4,6-tetrahydropyran in 59-70% yield. The E-alkene derived enol ethers gave the C3 epimeric tetrahydrofuran. Inversion of the secondary alcohol in the tetrahydropyran ring was partially accomplished using a Mitsunobu reaction. This methodology led to the racemic and asymmetric syntheis of the B ring of lasonolide A. The racemic synthesis was accomplished in 8 steps from 3-buten-1-ol. An asymmetric synthesis was also accomplished in 12 steps from (R)-malic acid. The quaternary stereogenic center of the A ring of lasonolide A was constructed via C-H insertion reaction using Doyle's catalyst (Rh2(4R-MEOX)4).
Download or read book Studies Toward the Total Synthesis of Calyculin A written by Samuel William Gerritz and published by . This book was released on 1993 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of leiodermatolide and Studies Towards the Structure Determination of Patellazole B written by Kenneth King-Hei Ng and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Total Synthesis of Natural Products Volume 1 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Download or read book Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of Aryl Ketones written by Robert Doran and published by Springer. This book was released on 2015-06-24 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.
Download or read book Studies in Natural Product Synthesis written by Irina Albrecht and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis and Structure Elucidation of Leiodolide A written by Katy M. Mould and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of the Tedanolides written by Lisa Deanna Julian and published by . This book was released on 2005 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Jodrellin B and the Synthesis of Previously Inaccessible Bridehead Sultams by Radical and Anionic Intramolecular Cyclization written by Jeffrey D. Schloss and published by . This book was released on 2001 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Bryostatin 1 written by David Curtis Whritenour and published by . This book was released on 1988 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
