Download or read book Studies Towards the Total Synthesis of Lactonamycin written by Johnathan Board and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward a Total Synthesis of Lactonamycin written by Lewis Preece and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Work was undertaken towards the synthesis of the promising antibiotic lactonamycin (iii). Following the work of Parsons et al. it was proposed that cyclisation of the ene-diyne (i) would give access to advanced pentacyclic intermediate (ii) and that from this a total synthesis of lactonamycin would be achieved (scheme I). Scheme I : Proposed Parsons, Board, Waters cyclisation to form the pentacycle (iii)(For image refer to pdf). A synthesis towards the cyclisation precursor (i) was carried out and a route to the key tetrasubstituted phthalide (v) established. Further chemistry was proposed to complete the synthesis of lactonamycin (scheme II). Scheme II : Formation of a fully substituted benzolactone.(For image refer to pdf). During attempts to introduce the [beta]-bromoallyl group of key intermediate (v) using a high temperature Claisen rearrangement it was established that the benzodioxin (vii) underwent thermolysis to generate the reactive quinone methide intermediate (viii) and that in the presence of a nucleophilic solvent the adduct (ix) was formed (scheme III). Model studies showed the reaction to be both general and high-yielding. Scheme III : Novel quinone methide methodology. (For image refer to pdf).
Download or read book Studies Towards the Total Synthesis of Lactonamycin written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Total Synthesis of Lactonamycin written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Total Synthesis of Lactonamycin written by Sylvain Michel Matthieu Arthur Jacques and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of the CDEF Ring System of Lactonamycin written by Ronan Le Vézouet and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of the Antibiotic Lactonamycin written by Lee Walsh and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Cochleamycin A written by Krista Beaver Goodman and published by . This book was released on 2002 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Milbemycin D written by Isabelle M. Vallin and published by . This book was released on 1993 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward an Enantioselective Total Synthesis of Duocarmycin A written by Philippe Gastaud and published by . This book was released on 1997 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Calyculin A written by Samuel William Gerritz and published by . This book was released on 1993 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Vancomycin written by Andrew Michael Ratz and published by . This book was released on 1996 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of a Novel Isocyanide Multicomponent Reaction for the Generation of Highly Substituted Amides written by Nicolas Mickaël Fédou and published by . This book was released on 2007 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Asymmetric Total Synthesis of Geldanamycin written by Erik L. Meredith and published by . This book was released on 2002 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis of lemonomycin written by Yuyin Chen and published by . This book was released on 2006 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Asymmetric Total Synthesis of Geldanamycin Via a Ring closing Metathesis Route written by Russell R. Glancy and published by . This book was released on 2002 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Total Synthesis of Anthracimycin written by Laksamee Jeanmard and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
