Download or read book Studies on the Fibrinogen fibrin Conversion and Mechanical Properties of Fibrin Clots written by Marsha D. Bale and published by . This book was released on 1982 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fibrous Proteins Structures and Mechanisms written by David A.D. Parry and published by Springer. This book was released on 2017-01-18 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described are fibrous proteins based on the β-pleated sheet and collagen conformations. Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications. Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade. This book, written by recognized authorities in the field, provides a clear account of the current status of fibrous protein research and, in addition, establishes the basis for deciding the most appropriate directions for future activity, including the applications of protein engineering and the commercial exploitation of new biomaterials.
Download or read book Single Fibrin Fiber Mechanical Properties and Lysis written by Wei Li and published by . This book was released on 2015 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states. Cardiovascular disease (CVD) and diabetes are among the leading causes of death and disability globally. We determined the mechanical properties of single fibrin fibers from individuals who suffered from these diseases by using a combined atomic force microscope/fluorescence microscope. We found that fibrin fibers from healthy individuals are less stretchable and elastic than those from CVD patients (who also took aspirin). This indicates that there is a structural change in fibrin fiber for CVD patients (who also taking aspirin). In contrast, diabetes did not affect any fibrin fiber mechanical properties. Moreover, we found that the modulus, Y, decreases exponentially with fiber diameter, D, typically as Y ~ D−1·5, except for CVD samples for which Y ~ D−1·0. To explain this phenomena, we propose a novel model for the internal structure of fibrin fibers, in which they have a densely packed core and less dense periphery. Another important system in blood, fibrinolysis (the dissolution of blood clots), is influenced by many factors. Since fibrin fibers (clots) experience strain (shear force) by blood flow naturally, we also investigated the effect of external tension on fibrinolysis. We created a novel biocompatible stretchable substrate made from fugitive glue to stretch single fibrin fiber. We found that fiber stretching slows down lysis of single fibrin fibers and this effect is more pronounced than the slowing influence of FXIII mediated fibrin crosslinking on lysis.
Download or read book Trauma Induced Coagulopathy written by Hunter B. Moore and published by Springer Nature. This book was released on 2020-10-12 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
Download or read book Studies on Fibrinogen written by Birger Blombäck and published by . This book was released on 1958 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Some Physical Chemical Studies of the Conversion of Fibrinogen to Fibrin written by Ignacio Tinoco and published by . This book was released on 1954 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Adhesion of Fibrin Clots written by Arthur Louis Seiler and published by . This book was released on 1949 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Macromolecular Protein Complexes III Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-11-30 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Importance of the Fibrinogen C connector in Fibrin Fiber Mechanical Properties and Automated Fiber Diameter Measurements in SEM Images of Fibrin Clots written by Ali Daraei and published by . This book was released on 2020 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Laboratory Techniques in Thrombosis a Manual written by J. Jespersen and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this manual appeared in 1992 and was entitled ECAT Assay Procedures. It was the result of a unique cooperation between experts brought together by the European Concerted Action on Thrombosis and Disabilities (ECAT). The Concerted Action was at that time under the auspices of the Commission of the European Union. The second edition, like the first edition, deals with diagnostic tests within the field of thrombosis. However, the second edition has a broader scope because it is no longer limited by the frontiers of ECAT. Experts allover the world, in and outside ECAT, have contributed to this edition. The editors are very grateful for their contributions. The need for a new edition is obvious. Since 1992 new assays have been introduced for research, diagnosis, and therapy of thrombosis; for other assays improvements have been suggested, while a few others became redundant. The editors waived the radioimmunoassays of ~-thrombog1obulin and platelet factor 4 due to the fact that the kits required for these assays are rarely, or no longer, available. Also the PAI-1 activity assay was waived as it is liable to many inconsistencies and to large variations. A list of names and addresses of manufacturers marketing the kits and reagents has been compiled, together with a list of the recommended nomenclature of quantities in thrombosis and haemostasis, in order to facilitate the use of the updated version. These lists have been carefully compiled by Johannes J. Sidelmann, PhD, Department of Clinical Biochemistry in Esbjerg, Denmark.
Download or read book Vascular Medicine A Companion to Braunwald s Heart Disease E Book written by Mark Creager and published by Elsevier Health Sciences. This book was released on 2019-05-22 with total page 963 pages. Available in PDF, EPUB and Kindle. Book excerpt: With authoritative coverage of everything from recent discoveries in the field of vascular biology to recent clinical trials and evidence-based treatment strategies, Vascular Medicine, 3rd Edition, is your go-to resource for improving your patients' cardiovascular health. Part of the Braunwald family of renowned cardiology references, this updated volume integrates a contemporary understanding of vascular biology with a thorough review of clinical vascular diseases, making it an ideal reference for vascular medicine specialists, general cardiologists, interventional cardiologists, vascular surgeons, and interventional radiologists. - Incorporates technologic advances in vascular imaging – including ultrasound, MRI, CTA, and catheter-based angiography – along with more than 230 new figures, providing an up-to-date and complete view of the vascular system and vascular diseases. - Covers novel antithrombotic therapies for peripheral artery disease and venous thromboemboism, advances in endovascular interventions for aortic aneurysms, and today's best surgical treatments for vascular diseases. - Includes seven new chapters: Pathobiology of Aortic Aneurysms; Pathobiology and Assessment of Cardiovascular Fibrosis; Large Vessel Vasculitis; Medium and Small Vessel Vasculitis; Epidemiology and Prognosis of Venous Thromboembolic Disease; Fibromuscular Dysplasia; and Dermatologic Manifestations of Vascular Disease. - Discusses methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. - Keeps you current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
Download or read book Cardiac Tissue Engineering written by Milica Radisic and published by Humana Press. This book was released on 2014-07-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.
Download or read book Regenerative Nephrology written by Michael S. Goligorsky and published by Academic Press. This book was released on 2010-11-26 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
Download or read book Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair written by Mario Barbosa and published by Woodhead Publishing. This book was released on 2017-09-25 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. - Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration - Explores protein and peptides from the fundamentals, to processing and applications - Written by an international group of leading biomaterials researchers
Download or read book Caplan s Stroke E Book written by Louis Caplan and published by Elsevier Health Sciences. This book was released on 2009-06-24 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated and revised, this new edition of Caplan’s Stroke continues to provide a concise and pragmatic approach to the evaluation, diagnosis, and management of adult and pediatric stroke patients. Dr. Caplan—a highly esteemed stroke authority— shares with you his vast experience and wisdom as a stroke clinician, including his time-tested strategies and unique clinical pearls that you can implement into your own practice. Expanded coverage of imaging and laboratory diagnosis and treatment as well as extensive revisions throughout, brings you the latest advances on prevention, complications, and rehabilitation. The use of case studies illustrates the types of clinical scenarios you may experience in practice. And, its conversational, easy-to-read format make Caplan’s Stroke an ideal resource for general neurologists, non-neurologists, and stroke specialists alike. Discusses all cerebrovascular diseases to help you differentiate among all types of stroke so you can treat each patient appropriately. Takes a distinctly personal and individual approach to general principles, pathophysiology, diagnosis, treatment, and rehabilitation, offering practical, clinical guidance on stroke and stroke related issues. Provides detailed discussions on stroke syndromes in children and adults, including large artery occlusive disease of the anterior circulation, brain embolism, spinal cord stroke, and many, many more, to help you better manage every condition you see. Uses case studies to highlight and emphasize clinical points. Includes expanded coverage of imaging and laboratory diagnosis and treatment to help you make better informed evaluation and management decisions. Presents meticulous revisions and updates throughout, particularly to the chapters on stroke prevention and rehabilitation to keep you current on today’s best practices. Features a new two-color design with updated artwork and more images that elucidates key points and enhances visual guidance.
Download or read book Data Interpretation in Anesthesia written by Tilak D. Raj and published by Springer. This book was released on 2017-09-09 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the interpretation of data commonly available to anesthesiologists, this book presents a data point, followed by discussion in a question and answer format. Covering EKG's, X-Rays, MRI's, graphs, paper recordings, blood gas results, laboratory results, patient case histories and more, Data Interpretation in Anesthesia provides an enhanced and stimulating learning format for residents in training and practitioners alike.
