Download or read book Studies on Cutaneous Human Papillomaviruses and Their Association with Non melanoma Skin Cancer written by Sarah Jackson and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Cutaneous Human Papillomaviruses Adn Their Association with Non melanoma Skin Cancer written by S. E. Jackson and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Study on the Potential Role of Cutaneous Human Papillomaviruses in the Development of Non melanoma Skin Cancer written by and published by . This book was released on 2005 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cutaneous Human Papillomaviruses and Non melanoma Skin Cancer written by and published by . This book was released on 1998 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Papillomaviruses and Polyomaviruses in Skin Cancer written by Herbert Johannes Pfister and published by Frontiers Media SA. This book was released on 2019-02-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonmelanoma skin cancer (NMSC), more recently defined as keratinocyte carcinoma (KC), is the most frequent malignant tumor among Caucasians. This book deals with widely distributed cutaneous papillomaviruses and polyomaviruses, which are able to establish life-long persistent infections. They are frequently clinically inapparent in the general population, but can cause skin cancer in immunocompromised hosts or in the aging skin undergoing immunosenescence, thereby leading to major medical problems. The incidence of cutaneous squamous cell carcinoma (cSCC) in immunosuppressed organ transplant recipients is 60-250 times higher than that observed in the general population, which is highly suggestive of viral etiology. The treatment of metastatic melanoma with BRAF-inhibitors can induce cSCC formation within only 8-12 weeks. The clinicopathological characteristics of these tumors led to speculations on a possible involvement of oncogenic viruses. The evidence presented in this eBook indicates that high priority should be given to the implementation of a prophylactic and/or therapeutic vaccination program against cutaneous papillomaviruses to prevent NMSC in immunosuppressed allograft recipients.
Download or read book The Role of Human Papillomaviruses and Their Replication in Nonmelanoma Skin Cancer written by Lorna J. Mackintosh and published by . This book was released on 2011 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonmelanoma skin cancer (NMSC) is the commonest cancer worldwide and is a significant and increasing burden on health care resources. NMSC aetiology is fundamentally linked to sun exposure although infection with oncogenic viruses including Human Papillomaviruses (HPV) is thought to be a cofactor. Fair skinned populations residing in geographical areas with high sun exposure have an increased incidence of NMSC and an excess of NMSC is also observed in certain patient groups including immunosuppressed organ transplant recipients. This thesis describes the epidemiology of NMSC in the immunosuppressed renal transplant population in the West of Scotland. Clinical samples from this population were investigated for the presence of HPV utilising a PCR reverse hybridisation technique. This assay specifically examined for HPV of the genus Beta that have been previously linked to NMSC. The effect of presence of HPV in these samples was evaluated through an investigation of the expression of cellular biomarkers. A biomarker expression pattern specific to HPV infected lesions would add further support to the link between HPV and NMSC. Samples were probed for Ki67, p16, p53, MCM2 and MCM5 antigens in addition to novel antigen, Topoisomerase II Beta Binding Protein 1 (TopBP1). TopBP1 is a host cellular protein that is involved in the DNA damage response and is an interacting partner for HPV thus making it a likely candidate for involvement in cutaneous carcinogenesis. A biomarker expression pattern specific to HPV infected NMSC was not identified although aberrant expression of TopBP1 was identified in a subset of skin cancers. To investigate this novel observation, a molecular investigation of the interaction between TopBP1 and the viral replication factor E2 was carried out, firstly in HPV-16 before extending the work to the cutaneous virus HPV-8. A mutant of HPV-16E2 that failed to bind TopBP1 was generated. Failure to bind TopBP1 resulted in a phenotype exhibiting compromised viral replication. The equivalent mutation generated in HPV-8E2 resulted in an even more compromised replicative phenotype. In addition to this work, gene targets of TopBP1 were also identified by a microarray analysis. This was carried out using MCF7 cells untreated or damaged by ultraviolet radiation (UVR) with endogenous TopBP1 depleted by SiRNA treatment. These studies showed that TopBP1 is involved in a number of cellular processes and is likely to be involved in controlling DNA damage targets following UVR induced DNA damage. The work described in this thesis provides further evidence supporting the role of HPV in the aetiology of nonmelanoma skin cancer. Generation of an E2 mutant that fails to bind TopBP1 and exhibits a compromised replication phenotype provides further evidence to support the hypothesis that the E2-TopBP1 interaction is essential for viral replication and therefore the viral life cycle. This work may facilitate the development of anti-viral therapies for HPV-associated disease by targeting HPV DNA replication through disruption of the E2/TopBP1 interaction.
Download or read book Case Control Study of Sunlight Exposure and Cutaneous Human Papillomavirus Seroreactivity in Basal Cell and Squamous Cell Carcinomas of the Skin written by Michelle R. Iannacone and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-melanoma skin cancer (NMSC), comprised of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is the most common cancer in Caucasians. Ultraviolet radiation (UVR) exposure is the most important environmental risk factor for both BCC and SCC development. However, the precise relationship between UVR and the risk of NMSC is complex, and the relationship may differ by skin cancer type. It has been hypothesized that intermittent patterns and childhood sunlight exposure are important for BCC while continuous (chronic) and lifelong (i.e. childhood and adulthood) sunlight exposure is important for SCC. Epidemiologic studies have demonstrated that cutaneous human papillomavirus (HPV) infection may also be a risk factor for developing NMSC. However, the pathway by which cutaneous HPV is associated with NMSC remains unclear. It is hypothesized that UVR exposure may interact synergistically with cutaneous HPV in NMSC development. The goal of the research study was to evaluate the relationship between levels of sunlight exposure and BCC and SCC and to investigate differences in sunlight-associated BCC and SCC risk by genus-specific cutaneous HPV serostatus. To address these goals, we conducted a clinic based case-control study of histologically confirmed BCC and SCC cases recruited from a university dermatology clinic and controls with no history of cancer and screened negative for current skin cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between measures of sunlight exposure and BCC and SCC. Multiplicative interactions were tested by placing an interaction term for the product of genus-specific HPV seroreactivity and sunlight related factors in the logistic regression models. Measures of both intermittent and continuous patterns of sunlight exposure were associated with both types of skin cancer (i.e. BCC and SCC).
Download or read book A Putative Role for Cutaneous Human Papillomaviruses in the Pathogenesis of Non melanoma Skin Cancers written by Thirunavukarasu Surentheran and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book High Risk Cutaneous Squamous Cell Carcinoma written by Chrysalyne D. Schmults and published by Springer. This book was released on 2016-04-29 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.
Download or read book The Papovaviridae written by Peter M. Howley and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Papillomaviruses and the Molecular Pathogenesis of Non melanoma Skin Cancer Associated with Organ Transplantation written by Catherine Anne Harwood and published by . This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Viral Oncology written by George Klein and published by . This book was released on 1980 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Papillomavirus and the Molecular Pathogenesis of Non melanoma Skin Cancer Associated with Organ Transplantation written by and published by . This book was released on 2003 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Seroepidemiology of Human Papillomavirus in Relation to Non melanoma Skin Cancer written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Non melanoma skin cancer in HIV infection written by Sacha Imran Goolamali and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biology of Skin Cancer excluding Melanomas written by O. D. Laerum and published by . This book was released on 1981 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HPV and Cancer written by James A. Radosevich and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: “HPV and Cancer” is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes. We then look at the dynamic trends of this infectious agent in the human population, how it interacts with human cells, and the role it plays with other organisms to produce both benign and malignant tumors. Lastly, there is a discussion about a new vaccine for HPV and the hopes that are held by many to change the trends with this virus and the associated cancers it produces.
