Download or read book Studies on C3 the Third Component of Human Complement written by Michael James Saya and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Third Component of Complement written by John D. Lambris and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. Its multifunctio nality is based on its ability to interact specifically with multiple serum complement proteins, cell surface receptors, and mem brant;-associated regulatory proteins. One of its most intriguing strategies of interaction with cell surfaces is the covalent binding of activated C3 through the internal thioester. The field has expanded over the past 10 years and a wealth of information has accumulated. C3 from various species and many of the human C3 binding proteins have been cloned and expressed. Numerous cellular responses mediated by the diffe rent fragments of C3 have been described. The findings that C3 interacts in a ligand-receptor-like fashion with proteins of nonself origin such as the gC of herpes simplex virus, a 70-kDa protein from Candida albicans, proteins from Epstein-Barr virus, etc. has opened a new field of investigation. The papers assembled in this volume summarize the wealth of data on the various aspects of the C3 interactions; together they bring to the reader new information on the chemistry, molecular gene tics, biology, and pathophysiology of C3 and C3-binding proteins. Emphasis is given to structural features as they relate to functions. Spring 1989 JOHN D. LAMBRIS, HANS J. MULLER-EBERHARD Table of Contents J. E. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . . . . . . . . . . . 1 S. R. BARNUM, G. FEY, and B. F. TACK: Biosynthesis and Genetics of C3 . . . . . . . . . . . . .

Download or read book The Immunoglobulins written by Roald Nezlin and published by Academic Press. This book was released on 1998-05-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Describes recent reviews on the structure and function of immunoglobulin molecules of various species Summarizes in detail recent findings on the fine structure of the antigen-combining site Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties Presents extensive references and is lavishly illustrated

Download or read book Molecular Interaction Studies of Human Complement C3 and Its Regulation written by and published by . This book was released on 2015 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Interaction Studies of Human Complement C3 and Its Regulation written by Elizabeth Rodriquez and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Complement in Health and Disease written by Keith Whaley and published by Springer. This book was released on 1987-03-31 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'The extensive subject index with about 400 entries makes the book easy to use for fast access to information. An excellent book' Karger, Vol. 5, No. 2, 1988

Download or read book The Complement System written by Klaus Rother and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon contemplating an updated version of the 1974 edition of this book and envisioning its possible organization, it immediately became evident that the new version could no longer be written by one, two, or even three authors. The field has experienced an explosive expansion in various directions, and the wealth of newer data which has been accumulated over the last decade can hardly be presented by a single author in a critical and coherent manner. On the other hand, it appears worthwhile not to abandon the attempt to come foreward with a review which describes as comprehensively as possible the progress and the state of knowledge. It is the aim of this volume to present a general and comprehensive review on complement. It is intended not only for individuals working in this area, but also for those who are less familiar with the field. Several chapters in the book describe state-of-the-art experimental methods which are helpful to critically evaluate the experimental data. Simultaneously, they may provide the necessary technical tools for those who wish to enter this highly provocative and exciting field.

Download or read book The Complement FactsBook written by Bernard J. Morley and published by Academic Press. This book was released on 2000 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complement system is a protein system that combines with antibodies to form a defense against bugs and viruses. This book contains entries on all its components, including C1q and lectins, serine proteases, and terminal pathway proteins.

Download or read book Bacteria Complement and the Phagocytic Cell written by Felipe C. Cabello and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytic cells and complement are probably the most important components of host defense against bacteria which, after overcoming the mucosal and epithelial barriers, multiply in the subepithelial tissue and may threaten to disseminate and invade the blood stream and different organs. Questions concerning the factors which regulate the interactions of the bacterial cell with host defenses are a challenge to research and lead to practical applications for the prevention, treatment and diagnosis of infectious diseases. The questions of expression and regulation of virulence related bacterial genes and gene products, the specific mechanisms of defence reactions by complement and phagocytic cells, their mutual interactions with bacteria and especially bacterial surfaces are focused. Considerations on how to translate this knowledge into the management of infectious diseases are also included.

Download or read book Analysis of Covalent Binding Reactions Between Human Complement Component C3 and Other Proteins of the Alternative Pathway written by Claire Louise Harris and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pediatric Allergy Principles and Practice E Book written by Donald Y. M. Leung and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.

Download or read book Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States written by Elizabeth Catherine Miller and published by . This book was released on 2012 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complement system is an essential branch of the innate immune system and acts as a bridge to the adaptive immune system. It serves as the first line of defense against pathogens, as well as in the clearance of immune complexes and apoptotic cells. Deficiencies in many of the complement components lead to an increase in bacterial infections while others predispose to autoimmune conditions, especially systemic lupus erythematosus (SLE). Regulation of the complement system is important for protection of the host tissues against inappropriate activation. In the absence of appropriate regulation, commonly due to mutations in regulatory proteins, complement can attack self-cells. This thesis work will examine two situations in which the central component of complement, C3, is involved in a human disease state. In the first case, there is a loss of appropriate regulation of C3 and in the second an autoantibody to the C3 convertase leads to a secondary C3 deficiency. Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that primarily affects the kidneys. This disease is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Heterozygous mutations in the regulatory proteins Factor H, CD46 and Factor I have been shown to predispose to the disease. This is due to a lack of proper control of complement activation on endothelial cells in the renal microvasculature. The first goal of this thesis work was to characterize the functional consequences of heterozygous mutations in C3 that have been identified in patients with aHUS. These mutant C3 proteins were expressed recombinantly in mammalian cells and characterized for functional changes. In ELISA binding studies, fluid phase cofactor assays and surface plasmon resonance, the majority of these proteins (11/17) had a defect in their interaction with CD46 or Factor H, both critical C3 regulatory proteins. Additionally, one mutation, R139W, led to increased binding of Factor B, resulting in formation of an inappropriately stabilized alternative pathway C3 convertase and, secondarily, to an undesirable increase in C3 activation. Complete C3 deficiency predisposes to multiple pyogenic bacterial pathogens and was lethal in early childhood prior to the advent of antibiotics. Additionally, C3 deficiency impairs the antibody response to vaccinations and causes a defect in dendritic cell maturation. In the second part of this thesis, I will describe a case of C3 deficiency in an 18 year-old patient who presented with a life-threatening Neisseria meningitides infection. He had a zero whole complement titer (CH50) and C3 antigen was not detected in the standard hospital laboratory tests. Sequencing of his C3 DNA did not reveal any mutations or truncations. Further analysis of his serum demonstrated quite low levels of C3 degradation products. Mixing the patient's serum with normal human serum led to an accelerated C3 turnover followed by the expected degradation of the C3 activation products. In hemolytic assays performed to assess the decay of the classical pathway C3 convertase, his serum stabilized the convertase, preventing its decay. Finally, it was determined that the factor stabilizing the C3 convertase was in the IgG fraction of the patient's serum. This factor, presumably an acquired autoantibody to the convertase, appears analogous to a previously reported C4 nephritic factor observed in a few patients with glomerulonephritis. However, this patient's presentation is unique and two years later he does not have renal disease. The studies presented here establish that mutations in C3 predispose to the development of aHUS due to inadequately regulated activation of the complement cascade. These data are the first described example of C3 mutations leading to this disease. The second part of this work focuses on a novel case in which stabilization of the classical pathway C3 convertase by an autoantibody led to complete loss of functionally intact C3. Together, this work emphasizes the requirement for precise regulation of complement activation at the key C3 step.

Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.

Download or read book Innate Immunity of Plants Animals and Humans written by Holger Heine and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.

Download or read book Origin and Evolution of the Vertebrate Immune System written by L. Du Pasquier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.

Download or read book Human Complement Component C3 microform Mapping of Sites of Interaction with C3 Binding Proteins by Site directed Mutagenesis written by Aiko Taniguchi-Sidle and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1995 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glomerulonephritis written by Howard Trachtman and published by Springer. This book was released on 2019-04-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as a convenient, state-of-the-art and comprehensive resource on the pathogenesis, diagnosis, and treatment of glomerular diseases. Clinical approaches, modalities and challenges are provided, along with new developments since the publication of Kidney Disease Improving Global Outcomes (KDIGO): Glomerulonephritis. Chapters dedicated to glomerular diseases mirror the current classification schemes used by Nephrologists and Pathologists and will include definition and natural history, epidemiology, clinical manifestations, pathology, diagnosis, differential diagnosis, treatment (algorithms when appropriate), prognosis and future prospects and current direction of research. Contributing authors consist of internationally renowned glomerulonephritis experts, renal pathologists and clinical nephrologists who are engaged in the management of glomerular diseases in clinical pediatric and internal medicine practices. Glomerulonephritis fills a considerable knowledge gap for general nephrologists, providers involved with the care of patients with glomerular diseases, and researchers. It should also be of value to medical students, interns, residents and fellows, as well as all clinicians engaged in medical education.