Download or read book Studies of Chemosensory Signal Transduction in Caenorhabditis Elegans written by Kayvan Roayaie and published by . This book was released on 1996 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory Mechanisms of Chemosensory Signaling in Caenorhabditis Elegans written by Michelle Christine Krzyzanowski and published by . This book was released on 2015 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: All animals rely on their ability to sense and respond to their environment to survive. While similar signal transduction pathways are implicated in both C. elegans and vertebrate chemosensation, there are still large gaps in our understanding of the mechanisms used to regulate signaling in these systems. In my thesis, I have identified a new role for the C. elegans cGMP-dependent protein kinase (PKG) EGL-4 in the negative regulation of nociceptive chemosensory signaling. Nociceptive sensory systems detect harmful stimuli and allow for the initiation of protective behavioral responses. The polymodal ASH sensory neurons are the primary nociceptors in C. elegans. The data suggest that EGL-4 negatively regulates signaling and behavior by activating known inhibitors of G protein-coupled signal transduction, RGS proteins. Using C. elegans behavioral response to aversive stimuli as the readout for neuronal activity, I provide the first evidence for PKG regulation of RGS function in sensory neurons in any system. Additionally, the suitability of a behavioral response is context-dependent, and must reflect both an animal's life history and its present internal state. Based on the integration of these variables, an animal's needs can be prioritized to optimize survival strategies. I show that cGMP movement through a gap junction neural network allows dynamic repurposing of several C. elegans head sensory neurons to regulate ASH sensitivity through EGL-4 function in response to an animal's feeding status. Such decentralized regulation of ASH signaling allows for rapid correlation between an animal's internal state and its behavioral output, and lends an unexpected modulatory flexibility to this hard-wired nociceptive neural circuit.
Download or read book Molecular Genetic Analysis of Chemosensory Behaviors in C Elegans written by Joseph H. Chou and published by . This book was released on 1998 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Download or read book Transduction Channels in Sensory Cells written by Stephan Frings and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.
Download or read book E coli in Motion written by Howard C. Berg and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Escherichia coli, commonly referred to as E. coli, has been the organism of choice for molecular genetics for decades. Its machinery and mobile behavior is one of the most fascinating topics for cell scientists. Scientists and engineers, not trained in microbiology, and who would like to learn more about living machines, can see it as a unique example. This cross-disciplinary monograph covers more than thirty years of research and is accessible to graduate students and scientists alike.
Download or read book The Molecular Basis of Smell and Taste Transduction written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent application of the techniques of molecular biology and patch-clamp physiology has led to rapid advances in understanding the molecular events in chemosensory transduction. In this book, the latest results are presented and discussed by leading scientists. The extensive coverage encompasses many important topics, including mucous domains; microchemical heterogeneity in the mucociliary complex of the olfactory epithelium; membrane currents and mechanisms of olfactory transduction, and genetic and pathological taste variation.
Download or read book Analysis of Diverse Signal Transduction Pathways Using the Genetic Model System Caenorhabditis Elegans written by Celine Moorman and published by . This book was released on 2003 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Signal Transduction in Chemosensory Neurons of Mice written by Daniela Brunert and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Oxford Handbook of Invertebrate Neurobiology written by John H. Byrne and published by Oxford University Press. This book was released on 2019-01-29 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invertebrates have proven to be extremely useful model systems for gaining insights into the neural and molecular mechanisms of sensory processing, motor control and higher functions such as feeding behavior, learning and memory, navigation, and social behavior. A major factor in their enormous contributions to neuroscience is the relative simplicity of invertebrate nervous systems. In addition, some invertebrates, primarily the molluscs, have large cells, which allow analyses to take place at the level of individually identified neurons. Individual neurons can be surgically removed and assayed for expression of membrane channels, levels of second messengers, protein phosphorylation, and RNA and protein synthesis. Moreover, peptides and nucleotides can be injected into individual neurons. Other invertebrate model systems such as Drosophila and Caenorhabditis elegans offer tremendous advantages for obtaining insights into the neuronal bases of behavior through the application of genetic approaches. The Oxford Handbook of Invertebrate Neurobiology reviews the many neurobiological principles that have emerged from invertebrate analyses, such as motor pattern generation, mechanisms of synaptic transmission, and learning and memory. It also covers general features of the neurobiology of invertebrate circadian rhythms, development, and regeneration and reproduction. Some neurobiological phenomena are species-specific and diverse, especially in the domain of the neuronal control of locomotion and camouflage. Thus, separate chapters are provided on the control of swimming in annelids, crustaea and molluscs, locomotion in hexapods, and camouflage in cephalopods. Unique features of the handbook include chapters that review social behavior and intentionality in invertebrates. A chapter is devoted to summarizing past contributions of invertebrates to the understanding of nervous systems and identifying areas for future studies that will continue to advance that understanding.
Download or read book Chemosensory Context Conditioning in Caenorhabditis Elegans written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: These studies were designed to investigate how environmental cues are associated during a non-associative learning process by studying chemosensory context conditioning for habituation in the nematode Caenorhabditis elegans. In chemosensory context conditioning for habituation animals that are trained and tested in the presence of either a taste or smell context cue show greater retention of habituation to tap stimuli when compared to animals trained and tested in different environments. This thesis is based on the work of Rankin (2000), in which taste (sodium acetate) context conditioning of habituation, extinction and latent inhibition of the cue were demonstrated. Here, I have shown context conditioning for an olfactory chemosensory cue (diacetyl) and dissociated the taste and smell pathways for this form of learning. odr-7 worms, with non-functional AWA olfactory chemosensory neuron (that detects diacetyl), showed short-term context conditioning to the taste but not to smell; the reverse was true for osm-3 worms with non-functional taste chemosensory neurons. This dissociation allows me to distinguish learning genes from genes involved in the detection of taste or smell. I also demonstrated long-term associative memory (24h) for context conditioning; context conditioning did not enhance normal long-term habituation, however, it produced memory in a training procedure that normally does not produce memory. My results showed that glr-1 (an AMPA-type ionotropic glutamate receptor subunit) and nmr-1 (an NMDA-type ionotropic glutamate receptor subunit) mutant worms did not show either short- or long-term context conditioning. To identify one site of plasticity, I showed that NMR-1 in the RIM interneurons was critical to produce short-term olfactory context conditioning. These studies lay the foundation to elucidate the cellular mechanisms of non-associative and associative learning for both short- and long-term memory, and may provide insights into how interneurons i.
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-11-21 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book C Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Model Animals in Neuroendocrinology written by Mike Ludwig and published by John Wiley & Sons. This book was released on 2018-11-05 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Model Animals in Neuroendocrinology: From Worm to Mouse to Man offers a masterclass on the opportunities that different model animals offer to the basic understanding of neuroendocrine functions and mechanisms of action and the implications of this understanding. The authors review recent advances in the field emanating from studies involving a variety of animal models, molecular genetics, imaging technologies, and behavior assays. These studies helped unravel mechanisms underlying the development and function of neuroendocrine systems. The book highlights how studies in a variety of model animals, including, invertebrates, fish, birds, rodents and mammals has contributed to our understanding of neuroendocrinology. Model Animals in Neuroendocrinology provides students, scientists and practitioners with a contemporary account of what can be learnt about the functions of neuroendocrine systems from studies across animal taxonomy. This is the seventh volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Download or read book Chemosensory Transduction written by Frank Zufall and published by Academic Press. This book was released on 2016-02-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included
Download or read book Peptide Receptors Part II written by A. Bjorklund and published by Elsevier Science. This book was released on 2002-12-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complementwith chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
