Download or read book Structure function Analysis of CKIP 1 and Investigation of Its Role in the Regulation of Protein Kinase CK2 written by Mary Ellen Kathleen Olsten and published by . This book was released on 2006 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinase CK2 From Structure to Regulation written by Khalil Ahmed and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.
Download or read book Protein Kinase CK2 written by Lorenzo A. Pinna and published by John Wiley & Sons. This book was released on 2013-01-14 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7
Download or read book Protein Kinase CK2 written by Lorenzo A. Pinna and published by John Wiley & Sons. This book was released on 2012-10-16 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7
Download or read book A Molecular and Cellular View of Protein Kinase CK2 written by Khalil Ahmed and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace. Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.
Download or read book Protein Kinase CK2 Cellular Function in Normal and Disease States written by Khalil Ahmed and published by Springer. This book was released on 2015-03-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
Download or read book Protein Kinase Ck2 From Structure to Regulation Biochemistry Essentials written by Michelle Mcguire and published by Syrawood Publishing House. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase 2 (CK2) is a serine/threonine-selective protein kinase that controls several signaling pathways. The structure of CK2 is tetrameric, which consists of two catalytic and two regulatory subunits. CK2 is a critical regulator of cell cycle progression and it has been observed to regulate cell cycle progression by protein-protein interactions. It is also involved in various biological processes such as DNA damage response, apoptosis, cell proliferation, cell cycle control, circadian rhythm regulation, transcription and translation. Furthermore, other functions of CK2 are related with human infections. There are certain viruses, which exploit the CK2 host cell for sustaining their life. CK2 activity has also been associated with various diseases including cancer, neurological diseases, inflammation, diabetes, obesity, diverse ophthalmic pathologies, and cardiovascular diseases such as cardiac hypertrophy and atherosclerosis. This book aims to shed light on the structure and regulation of protein kinase CK2. It aims to equip students and experts with the advanced topics and upcoming concepts in this area of study.
Download or read book From Structure to Function written by Barbara Guerra and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mitotic Regulation of Protein Kinase CK2 written by Nicole A. St. Denis and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinase CK2 is a serine/threonine kinase with a multitude of substrates and roles in many cellular processes, including mitosis. CK2 is constitutively active, yet we hypothesize that CK2 is indeed regulated in mitosis through subtle means, enabling CK2 to perform its functions unique to cell division. Our aims were to examine the roles of mitotic phosphorylation, subcellular localization, and interplay with mitotic kinases in the regulation of CK2 activity. We first examined the role of four highly conserved mitotic phosphorylation sites located in the unique C-terminus of CK2?. Phosphospecific antibodies generated against the sites show that CK2? phosphorylation is temporally regulated and occurs during prophase and metaphase during normal mitotic progression. Proper phosphorylation of CK2? is required for proper mitotic progression, as stable cell lines expressing phosphorylation site mutants of CK2? display severe mitotic defects. We next examined the impact of these phosphorylation events on the subcellular localization of CK2. We show that CK2?, but not CK2?', localizes to the mitotic spindle. Localization of CK2? to the mitotic spindle is phosphodependent, and requires the peptidyl-prolyl isomerase Pin1. These results are a rare example of functional divergence between the two catalytic isoforms of CK2, and suggest that the role of CK2? phosphorylation during mitosis is to promote localization of CK2 to the mitotic spindle. Finally, we examined the possibility that CK2 activity during mitosis is regulated through hierarchal phosphorylation events, wherein CK2 would phosphorylate proteins only after priming phosphorylation events catalyzed by other mitotic kinases, particularly Cdk1. As this phenomenon has never been systematically investigated, we have investigated the consensus requirements for CK2 primed phosphorylation, and in particular Cdk/CK2 hierarchical phosphorylation. A genome-wide search for potential mitotic substrates matching the consensus sequence suggests that Cdk1/CK2 hierarchical phosphorylation may indeed contribute to mitotic signaling, particularly on the mitotic spindle. Taken together, our results confirm the importance of CK2 in mitotic cell division, and highlight several examples of subtle regulation of CK2, through phosphorylation, subcellular localization, and interplay with other protein kinases. This helps explain how CK2, a constitutively active kinase, can participate in tightly regulated cellular processes like mitosis.
Download or read book Structure Function Analysis of Protein Kinase C and the Mechanistic Study of Annexin written by Michelle Digman and published by . This book was released on 2003 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solution Structure of the CAMP dependent Protein Kinase written by and published by . This book was released on 1998 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project as Los Alamos National Laboratory (LANL). Protein phosphorylation is well established as one of the most important mechanisms of signal transduction and cellular regulation. Two of the key enzymes that catalyze these phosphorylation reactions are the cAMP- (PKA) and cGMP- (PKG) dependent protein kinases. PKA has served as the prototypic model of this class of enzymes that now comprises in excess of 300 phylogenetically related proteins. A large number of these protein kinases are critical for the regulation of cell function and a full analysis of their similarities and differences is essential to understand their diverse physiological roles. The cAMP-dependent protein kinase has the subunit structure R2C2, in which C and R refer to the catalytic and regulatory subunits, respectively. The cGMP-dependent protein kinase (PKG) is highly homologous to PKA but is distinguished from it by having the regulatory and catalytic domains on a contiguous polypeptide. The studies described here use small-angle scattering and Fourier Transform InfraRed (FTIR) spectroscopy to study domain movements and conformational changes in these enzymes in different functional states in order to elucidate the molecular bases for the regulation of their activities.
Download or read book Genetic Manipulation of DNA and Protein written by David Figurski and published by IntechOpen. This book was released on 2013-02-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular biology of the cell written by and published by . This book was released on 2003 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book INTRO TO CYTOLOGY written by Lester W. (Lester Whyland) B. 18 Sharp and published by . This book was released on 2016-08-27 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Seeds written by Steve W. Adkins and published by CABI. This book was released on 2007-01-01 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings contain 43 papers on the aspects of seed conservation, development, biotechnology, germination, dormancy and ecology.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
