Download or read book Structure and Function of Apolipoproteins written by Maryvonne Rosseneu and published by CRC Press. This book was released on 1992-08-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure and Function of Apolipoproteins presents a comprehensive review of the primary and secondary structure of apolipoproteins. The book discusses the structure of the apolipoprotein gene family and genetic variation occurring at the protein level. Functional properties of apolipoproteins, including lipid binding, enzyme co-factor activity, antigenic properties, and receptor-ligand interactions are extensively described and analyzed in relation to their structural features. Physiological properties of apolipoproteins and their role in biology and medicine are also examined. Anyone who is interested in apolipoproteins or is conducting research on atherosclerosis should consider this volume an essential reference.
Download or read book Plasma Lipoproteins written by Antonio M. Gotto and published by Elsevier Publishing Company. This book was released on 1987 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this rapidly evolving field of research, an enormous amount of new knowledge of lipoprotein structure, function and metabolism has emerged. The 1985 Nobel Prize-winning pioneering work of Brown and Goldstein on the LDL receptor has had a profound impact on developments in the field. This work is one of the many subjects reviewed in detail in this book. The volume begins with chapters on structure, then proceeds to analysis of lipid and lipoprotein dynamics, metabolism, function, genetics, and molecular biology. Lipoprotein genetics in molecular biology, the role of lipoprotein receptors, and Lp(a) - a topic underrepresented in volumes on lipoproteins, are another three such topics in an impressive volume. This work will mainly be of interest to researchers interested in lipid and lipoprotein structure and metabolism, but will also be of great value to clinical medicine and biology in general.
Download or read book Lipoproteins Apolipoproteins and Lipases written by and published by Academic Press. This book was released on 1994-03-10 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains eight chapters that present both new and reviewed information fundamental to a clear understanding of lipid catabolism and transport at the molecular level. Three-dimensional structures of important serum lipoproteins, apolipoproteins, and lipases, utilizing X-ray data when available, are emphasized, and an attempt is made to relate structures to function. Amphipathic helix Apolipoprotein E Lipophorin Structure of serum albumin Lipid binding proteins Apolipoprotein B Low-density lipoprotein
Download or read book The Structure and Function of a Conserved Domain of Apolipoprotein E written by Demetrios T. Braddock and published by . This book was released on 1994 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lipoprotein a written by Angelo Scanu and published by Elsevier. This book was released on 2012-12-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on lipoprotein(a), commonly referred to as Lp(a). It covers a wide range of topics, including comparative biology, metabolism, structure, epidemiology, and treatment. Comprised of 15 chapters, the book starts with an overview of the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD), followed by a discussion on recent findings and developments. It then considers the relationship between elevated plasma Lp(a) and the inherited risk factor for the development of coronary heart disease. The reader is also introduced to the various components of Lp(a), which include neutral lipids, polar lipids, apoprotein(a), and apoprotein B. Other chapters discuss the specific functions of apolipoproteins in plasma lipid metabolism, which determine the fate of the various lipoprotein particles in plasma. This book will be of benefit to cardiologists and medical practitioners.
Download or read book Eicosanoids Apolipoproteins Lipoprotein Particles and Atherosclerosis written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifying lipoprotein particles.
Download or read book Structure Function and Atherogenicity of Apolipoprotein B Containing Lipoproteins written by Vian Anber and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dietary Sugar Salt and Fat in Human Health written by Harry G. Preuss and published by Academic Press. This book was released on 2020-03-06 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into four main sections, Dietary Sugar, Salt and Fat in Human Health explores the biochemical, pharmacological and medicinal aspects related to the overindulgence of dietary salt, sugar, and fat, along with possible remedies. Beginning with a general overview, the text outlines aspects associated with advancing age and human physiology, such as different aspects of insulin resistance, the advancing age phenomenon, central fat accumulation and metabolic perturbations and the role of the modern Western diet and the influence of dietary sugar, salt, and fat, with particular focus on their relation to multiple biochemical pathophysiological pathways. The second section of the book focuses on the roles of dietary sugars and their correlation with the chronic disease epidemic, with an emphasis on carbohydrate metabolism and its biochemistry, GI absorption, the glycemic index and the influence of fructose. The historical background of dietary sugars is discussed alongside Atkin’s hypothesis, and an overview of the correlation between dietary fibre and the glycemic index, including a chapter on sugar addiction. Section three contains an exhaustive review of the influence of dietary salt and its diverse mechanistic aspects, including salt-sensitive hypertension, contribution of two steroid receptor pathways, vascular NO, intrarenal RAAS system and angiotensin. The fourth section highlights the biochemistry of dietary saturated, polyunsaturated and trans fat and its influence on human health and various diseases, and further explores NAFLD and gender specific problems. Chapters in this section also investigate the benefits of the Mediterranean diet as well as myths related to cholesterol. Collected and carefully organized for researchers in nutrition, physiology, epidemiology, or sensory science, this book will also benefit general practitioners, surgeons, nurses, health professionals and practitioners, and students studying the role of diet in cardiometabolic disorders and disease. Demonstrates how a healthy lifestyle impacts lifespan Provides a general overview and outlines aspects associated with advancing age and human physiology Focuses on the roles of dietary sugars and their correlation with the chronic disease epidemic Contains an exhaustive review of the influence of dietary salt and its diverse mechanistic aspects Highlights the biochemistry of dietary saturated, polyunsaturated and trans fat and its influence on human health and various diseases
Download or read book An In vivo Approach to the Study of Apolipoprotein A 1 Structure function Relationships written by Daniel Charles McManus and published by . This book was released on 2001 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Apolipoprotein E written by Adeel Mohammad Siddiqui and published by . This book was released on 1989 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Structure and Function of Apolipoprotein A Iv written by and published by . This book was released on 2005 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apolipoprotein (apo) A-IV is a protein synthesized by the small intestine in response to lipid absorption. It has been proposed to play a role in cholesterol efflux, lipoprotein metabolism and food intake. Unfortunately, little information on its structure/function relationship is known. Therefore, it was important to establish a recombinant expression system for apoA-IV so deletion mutagenesis could be performed to achieve the specific aims. The following aims address the hypothesis that specific regions of apoA-IV are involved in its ability to interact with lipid and inhibit food intake. Aim 1: Determine the region of apoA-IV that is responsible for its ability to bind lipid as well as to identify the generalities of its structure. Initially, it was found that removing the C-terminal 44 amino acids from human apoA-IV caused a significant increase in lipid binding ability as compared to WT. Eventually, a smaller region from amino acid 333- 343 was established as the inhibitory region of apoA-IV at the C-terminus. Using the 333- 343 as a template, the N-terminus was also mutated and it was found that the N-terminal amino acids from 11-20 were required for the mutants to be fast lipid binders. Therefore, we propose there is an interaction between the inhibitory region from 333-343 and the N-terminus of the protein that does not allow the proper conformation for accelerated lipid binding. Aim 2: Determine the region of apoA-IV that is responsible for its role in the inhibition of food intake. Originally, several C-terminal deletion mutants were made in rat apoA-IV. The mutants were injected into the 3rd ventricle of rat brains and their food intake was determined. It was found that the food intake region was located in the N-terminal 116 amino acids. Next a 3rd mutant was made that removed the N-terminal 61 amino acids. This mutant did not inhibit food intake as compared to WT suggesting the region involved in food intake is located in the first 61 amino acids. In separate studies, a 14-residue peptide from amino acid 17-30 also inhibited food intake in rats suggesting this is the active region.
Download or read book Apolipoproteins written by Adrik D. Sidorov and published by Nova Science Publishers. This book was released on 2014-05-14 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues. In this book, the authors present current research in the study of the regulatory functions, health effects and role in disease of apolipoproteins. Topics include macrophages, apolipoproteins, steroid hormones and molecular mechanisms of cell proliferation; formation of discoidal apolipoprotein A-1 lipid bound complexes; the role of apolipoprotein E in cardiovascular and renal disease; the functional variants and mutations of the apolipoprotein A5 gene in human pathology; and regulation of FGF-1 of ApoE/HDL generation in astrocytes.
Download or read book High Density Lipoproteins written by Arnold von Eckardstein and published by Springer. This book was released on 2015-01-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
Download or read book Structure Function and Evolution of the Mammalian Apolipoproteins written by Mark Stanley Boguski and published by . This book was released on 1986 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book An In vivo Approach to the Study of Apolipoprotein A 1 Structure function Relationships written by Daniel Charles McManus and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Eicosanoids Apolipoproteins Lipoprotein Particles and Atherosclerosis written by Claude L. Malmendier and published by Springer. This book was released on 2011-10-18 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifying lipoprotein particles.
Download or read book Structure Function Analysis of Apolipoprotein A V written by Kasuen Mauldin and published by . This book was released on 2010 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary heart disease is the leading cause of death in the United States, and epidemiological studies have shown that an elevated plasma triglyceride level is an independent risk factor for cardiovascular disease. In 2001, a new member of the exchangeable apolipoprotein (apo) family, apoA-V, was discovered using comparative genomics. Studies with transgenic mice over-expressing human apoA-V and apoA-V knock-out mice have shown that there exists a negative correlation between apoA-V levels and plasma triglyceride concentrations. Such findings have also been observed in humans, where single nucleotide polymorphisms within the APOA5 gene have been associated with hypertriglyceridemia. These physiological findings suggest that apoA-V plays a major role in the regulation of triglyceride metabolism, and elucidating the mechanism by which apoA-V functions could yield therapeutic effects. Several features of apoA-V, including an extremely low plasma concentration, a lack of correlation with cholesterol levels despite its association with high density lipoprotein, and its insolubility at neutral pH in the absence of lipid, are unlike other exchangeable apolipoproteins. Findings indicate apoA-V is comprised of two independently folded structural domains, with the amino-terminal domain forming an amphipathic alpha-helix bundle in the absence of lipid. In the presence of lipid, the helix bundle motif is postulated to unfurl, exposing hydrophobic residues for lipid interaction. The carboxy-terminal region plays a key function in apoA-V lipid binding, consistent with its known association with plasma lipoproteins.
