Download or read book Structural Studies of the Malarial Proteins PfEMP1 and MIF from Plasmodium Falciparum written by and published by . This book was released on 2009 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Structural Studies of the Malrial Proteins PfEMP1 and MIF from Plasmodium Falciparum written by Sarah Elizabeth Dobson and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Structural Studies on Plasmodium Falciparum Erythrocyte Membrane Protein 1 PfEMP1 Malaria Antigens Using Small Angle X Ray Scattering SAXS written by Stig Christoffersen and published by . This book was released on 2014 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Structural Studies of Malaria Proteins written by Christina Mayer and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is a disease of global importance, causing hundreds of thousand of deaths a year. The majority or deaths are caused by Plasmodium falciparum, a parasite transmitted by the mosquito Anopheles. Its pathogenicity largely results from an ability to transform infected erythrocytes by creating knob-like structures that result in endothelial adhesion. Two major components of these knob structures have been identified as P. falciparum erythrocyte membrane protein 1 (PjEMPI) and knob-associated histidine rich protein (KAHRP). The extracellular fragment of PjEMPI is responsible for antigenic variability and cytoadherence while its intracellular domain (ATS) connects to the cytoskeleton via interactions with other plasmodium-encoded proteins. In addition, perforin-like proteins (PLPs) with a MACPF domain have been identified in the genome of Plasmodium. PLPs are highly conserved and are expressed in various life-cycle stages of the parasite. They are believed to form pores in membranes of the host cell but their structure is yet unknown. The aim of the work in this thesis was to obtain new information about the structure and role of malaria proteins, thus giving a better understanding of the disease and its possible treatment. Studies of numerous designed constructs of the ATS family were carried out using biophysical methods including high resolution NMR, SAXS and CD. These revealed that ATS domains are mainly unstructured with a relatively small folded core, consisting of a bundle of a-helices. Surprisingly, no evidence could be found for ATS binding to KAHRP in solution conditions although previous pull-down data had indicated an interaction. Bioinformatics analysis and yeast-two-hybrid data suggested, however, that there is a conserved protein interaction epitope on the central flexible part of ATS. It was shown, using fluorescence anisotropy measurements that this part of ATS associates with a parasite protein containing a PHIST (Plasmodium helical interspersed sub-telomeric) domain. Expression constructs of the PLP protein family were designed and manufactured, with the aim of enabling structural studies of these putative pore proteins.

Download or read book Structural Characterisation of the Interaction Between Plasmodium Falciparum Erythrocyte Membrane Protein 1 PfEMP1 and Their Human Ligands in Severe Malaria written by Hong Kin Ng and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Automated Structural Annotation of the Malaria Proteome and Identification of Candidate Proteins for Modelling and Crystallization Studies written by Yolandi Joubert and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is the cause of over one million deaths per year, primarily in African children. The parasite responsible for the most virulent form of malaria, is Plasmodium falciparum. Protein structure plays a pivotal role in elucidating mechanisms of parasite functioning and resistance to anti-malarial drugs. Protein structure furthermore aids the determination of protein function, which can together with the structure be used to identify novel drug targets in the parasite. However, various structural features in P. falciparum proteins complicate the experimental determination of protein three dimensional structures. Furthermore, the presence of parasite-specific inserts results in reduced similarity of these proteins to orthologous proteins with experimentally determined structures. The lack of solved structures in the malaria parasite, together with limited similarities to proteins in the Protein Data Bank, necessitate genome-scale structural annotation of P. falciparum proteins. Additionally, the annotation of a range of structural features facilitates the identification of suitable targets for structural studies. An integrated structural annotation system was constructed and applied to all the predicted proteins in P. falciparum, Plasmodium vivax and Plasmodium yoelii. Similarity searches against the PDB, Pfam, Superfamily, PROSITE and PRINTS were included. In addition, the following predictions were made for the P. falciparum proteins: secondary structure, transmembrane helices, protein disorder, low complexity, coiled-coils and small molecule interactions. P. falciparum protein-protein interactions and proteins exported to the RBC were annotated from literature. Finally, a selection of proteins were threaded through a library of SCOP folds. All the results are stored in a relational PostgreSQL database and can be viewed through a web interface (http://deepthought.bi.up.ac.za:8080/Annotation). In order to select groups of proteins which fulfill certain criteria with regard to structural and functional features, a query tool was constructed. Using this tool, criteria regarding the presence or absence of all the predicted features can be specified. Analysis of the results obtained revealed that P. falciparum protein-interacting proteins contain a higher percentage of predicted disordered residues than non-interacting proteins. Proteins interacting with 10 or more proteins have a disordered content concentrated in the range of 60-100%, while the disorder distribution for proteins having only one interacting partner, was more evenly spread. Comparisons of structural and sequence features between the three species, revealed that P. falciparum proteins tend to be longer and vary more in length than the other two species. P. falciparum proteins also contained more predicted low complexity and disorder content than proteins from P. yoelii and P. vivax. P. falciparumprotein targets for experimental structure determination, comparative modeling and in silico docking studies were putatively identified based on structural features. For experimental structure determination, 178 targets were identi_ed. These targets contain limited contents of predicted transmembrane helix, disorder, coiled-coils, low complexity and signal peptide, as these features may complicate steps in the experimental structure determination procedure. In addition, the targets display low similarity to proteins in the PDB. Comparisons of the targets to proteins with crystal structures, revealed that the structures and predicted targets had similar sequence properties and predicted structural features. A group of 373 proteins which displayed high levels of similarity to proteins in the PDB, were identified as targets for comparitive modeling studies. Finally, 197 targets for in silico docking were identified based on predicted small molecule interactions and the availability of a 3D structure.

Download or read book Biochemical Biophysical and Structural Studies of a Protein Complex Implicated in the Erythrocyte Interaction with the Malaria Parasite Plasmodium Falciparum written by Manuel Blanc and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies on the Structure and Function of the Major Merozoite Surface Protein MSP1 of the Malaria Parasite Plasmodium Falciparum written by Jonathan Andrew Chappel and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Malaria Genome Projects written by Irwin W. Sherman and published by World Scientific. This book was released on 2012 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers in detail the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Project came into being, the people who created it, and the cadre of scientists who are attempting to see the promise of the Project realized. The promise was: a more complete understanding of the genes of the parasite (and its vector) would provide a rational basis for the development of antimalarial drugs and vaccines, allow a better understanding of the regulation of the complex life cycle in the red blood and liver cells of the human, identify the genes the parasite uses to thwart the host immune response and the ways in which the parasite evades cure by drug treatments, as well as leading to more effective measures of control transmission. The hope was that cracking the genetic code of Plasmodium and Anopheles would reveal the biochemical Achilles heel of the parasite and its vector, leading to the development of novel drugs and better methods of control, and by finding the targets of protective immunity could result in the manufacture of effective vaccines. Through a historic approach, this book will allow for those new to the field, or those with insufficient background in the sciences, to have an easier entry point. Even scientists already working in the field may better appreciate how discoveries made in the past can impact the direction of future research.

Download or read book World Malaria Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2016-01-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.

Download or read book Nutritional Anemia in Preschool Children written by Anil Gupta and published by Springer. This book was released on 2017-08-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights intricate predisposing factors for pathogenesis of nutritional anemia. It delivers valuable information related to this public health hazard influencing the nutritional health of preschool children. The book is valuable for readers in diverse fields to gain insight of the concept of nutritional anemia in preschool children. Additionally, book furnishes clinical and laboratory methods in a comparative way to assess nutritional anemia. Impact of the disorder on health of preschool children has been covered in a simple language. The book mentions need for interventional strategies for the management of nutritional anemia. Infants, preschool children and women during pregnancy and lactation are highly susceptible to dietary deficiency of iron, folic acid and cyanocobalamin leading to comparatively, higher predisposition to development of nutritional anemia. The condition has myriad of ill effects on nutritional health of preschool children.

Download or read book Medical Parasitology written by Abhay R. Satoskar and published by CRC Press. This book was released on 2009-11-23 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections caused by parasites are still a major global health problem. Although parasitic infections are responsible for a significant morbidity and mortality in the developing countries, they are also prevalent in the developed countries. Early diagnosis and treatment of a parasitic infection is not only critical for preventing morbidity and mort

Download or read book Parasitology written by Eric Loker and published by Garland Science. This book was released on 2015-03-02 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitology: A Conceptual Approach focuses on the conceptual basis of parasitology, with the goal of providing students with an enriched view of parasites and their biology. Concentrating on concepts will enable readers to gain a broader perspective that will increase their ability to think critically about all kinds of parasitic associations. The interfaces between the study of parasitism and prominent biological disciplines such as biodiversity, immunology, ecology, evolution, conservation biology, and disease control are highlighted. Studying individual parasites is an essential part of parasitology so Parasitology: A Conceptual Approach contains an appendix which provides a concise overview of the biology of important human and veterinary parasites. End-of-chapter questions are provided, as is an instructor manual.

Download or read book World Malaria Report 2019 written by World Health Organization and published by . This book was released on 2019-08-28 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2019 provides a comprehensive update on global and regional malaria data and trends. The report tracks investments in malaria programs and research as well as progress across all intervention areas: prevention, diagnosis, treatment, elimination, and surveillance. It also includes dedicated chapters on the consequences of malaria on maternal infant and child health the "High Burden to High Impact" approach as well as biological threats to the fight against malaria. The 2019 report is based on information received from more than 80 countries and areas with ongoing malaria transmission. This information is supplemented by data from national household surveys and databases held by other organizations.

Download or read book Essentials of Medical Parasitology written by Apurba S Sastry and published by JP Medical Ltd. This book was released on 2018-10-31 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a complete guide to medical parasitology for undergraduate and postgraduate students. The new edition has been fully revised to provide the latest updates and advances in the field, highlighting epidemiology, diagnosis and treatment of numerous parasitic diseases. Presented in bullet format, the text is divided into four main sections, each further sub-divided to cover different parasites. The second edition covers recent advances in laboratory diagnosis, treatment guidelines, vaccine prophylaxis, epidemiology of infectious diseases, and hospital infection control. Each chapter features questions on the topic to assist revision, as well as clinical images, schematic diagrams, tables and flowcharts. Key points Complete guide to medical parasitology for students Fully revised, new edition covering latest advances in the field Includes questions on each topic to assist revision Previous edition (9789351523291) published in 2014

Download or read book Medical Parasitology written by Rohela Mahmud and published by Springer. This book was released on 2018-01-31 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook will provide a systematic comprehension of the various medically important human parasites; their distribution, habitat, morphology and life cycle, pathogenesis and clinical features, laboratory diagnosis, treatment, prevention and control. The main emphasis is on the protozoan and helminthic diseases, also medical entomology covering vectors relevant to these diseases. The book aims to promote an easy yet comprehensive way of learning parasitology. It attempts to break down the complexity of medical parasitology into parts that are easy to understand yet integrating the essential information of parasitic infections. The integration of knowledge of parasites will be achieved through student friendly illustrations, inclusion of a collection of recent case reports, examples of test questions and scenarios, and the images of human parasites. Essentially, it provides a “one-stop learning package” for medical parasitology.

Download or read book Malaria written by Irwin W. Sherman and published by Amer Society for Microbiology. This book was released on 1998-01 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every 30 seconds a death is caused by Malaria. This book brings together recent advances in our understanding of the basic biology, genetics and pathogenesis of malaria, to facilitate the rapid generation of new insights and interventions. Each chapter is written by a leading expert(s), and serves as both a useful introduction to the area and a helpful set of references. Malaria: Parasite Biology, Pathogenesis and Protection is a useful entry point for graduate and medical students, scientists and individuals engaged in a subspecialty of Malaria research, as well as those who are simply interested in getting a grasp on the present status of this ever burgeoning public health problem.