Download or read book Structural and Functional Analysis of Peptide Binding to Classs I MHC Molecules written by Dewey Howell and published by . This book was released on 2000 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book MHC Molecules Expression Assembly and Function written by Robert G. Urban and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3 nant expression systems have been used to make MHC molecules con taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesized. Briefly, the entire sequence of the tar get protein is chemically synthesized using overlapping peptides which are then screened for biological activity using standard T cell presen tation assays. Despite its limitations, this method was used to identify the first immunodominant epitopes reported in the literature and con tinues to be used successfully today.
Download or read book MHC Molecules and Peptides written by and published by . This book was released on 1994 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural and Functional Analysis of MHC Class II Molecules in Antigen Presentation microform written by Naveen Bangia and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of Peptide Binding to MHC Class I Molecules and the Function of Tapasin During the Binding Process written by Florian Sieker and published by . This book was released on 2008 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: MHC class I molecules play an important role in the adaptive immune response of mammalian immune systems. Class I molecules are loaded with antigenic peptides inside the endoplasmatic reticulum. After binding a high affinity peptide they are transported to the cell surface where their peptide cargo can be inspected by T-cells. In case the peptide cargo is recognized to be antigenic the T-cell will induce apoptosis of the infected cell. Despite their large structural similarity class I molecules differ in their dependence on tapasin. Tapasin is a chaperone protein and a part of the loading complex which is responsible for facilitating the binding of class I molecules and high affinity peptides. Several studies already revealed that even MHC molecules with almost identical sequences show great differences in their dependence on tapasin. Here I focus on two HLA-B alleles B*4402 and B*4405, respectively. The two alleles differ only at position 116 where the tapasin-dependent allele B*4402 carries an aspartate while the independent allele has a tyrosine. Although there are quite a number of hints for the function of tapasin the mode of action is still not known so far. Here, the difference between the two almost identical alleles was investigated to get an insight into the functioning of tapasin. Molecular dynamics simulations were performed to analyze the binding groove of MHC class I alleles which differ significantly in their tapasin-dependence with a high spatial and time resolution. Results suggested that one possible function of tapasin lies in stabilizing the alpha-2-1-helix which is next to the C-terminus of a bound peptide and near a proposed tapasin binding region at position 134.
Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
Download or read book Kinetic and Structural Analysis of Class II MHC peptide Complexes written by Michael N. Liang and published by . This book was released on 1997 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural and Functional Analysis of the MHC I Peptide loading Complex written by Andreas Blees and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Download or read book Protein Actions Principles and Modeling written by Ivet Bahar and published by Garland Science. This book was released on 2017-02-14 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Self and Nonself written by Carlos López-Larrea and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.
Download or read book Major Histocompatibility Complex written by M. Kasahara and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi zation of the MHC in humans and other model vertebrates, MHC-parasite co evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen eral.
Download or read book Antigen Processing and Presentation written by Robert Edward Humphreys and published by . This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few volumes dedicated to antigen processing, this unique text is not only especially current but also valuable for its description of petentially "hot" areas with its "Future Directions" sections. * Current, important topics covered by this text include: Processing and presentation of foreign and self protein antigens to T lymphocytes Intracellular assembley and transport of MHC proteins Regulation of the assembley and expression of processed antigen-MHC complexes
Download or read book MHC Volume 1 written by N. Fernandez and published by Oxford University Press. This book was released on 1997-08-21 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex is the subject of much research in the immunology area. There is great interest in the structure of MHC proteins and in their function as antigen presenting molecules. Many immunology labs are now faced with the prospect of tackling biochemical and genetic techniques in order to study these molecules, and these two Practical Approach volumes provide the ideal introduction. MHC 1, Antigen Processing and Presentation, is complemented by MHC 2, Genes, Cells, and Molecules.
Download or read book Cellular and Structural Requirements for Peptide Binding to MHC Class II Molecules written by Ghislaine Marie-Claude Hélène Poirier and published by . This book was released on 1992 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
