Download or read book Actinobacteria written by Dharumadurai Dhanasekaran and published by BoD – Books on Demand. This book was released on 2016-02-11 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.
Download or read book Streptomyces as a Source of Antimicrobials written by Paula Yag√oe and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Streptomyces is the most important bacterial genus for bioactive compound production. These soil bacteria are characterized by a complex differentiation cycle. Streptomyces is extremely important in biotechnology, producing approximately two thirds of all antibiotics, as well as many compounds of medical and agricultural interest. Drug discovery from streptomycetes became challenging once the most common compounds were discovered, and the system was basically abandoned by industry. Simultaneously, antibiotic resistance is increasing dramatically, and new antibiotics are required. Screening from nature is being resumed (exploring new environments, looking for elicitors, metagenome, etc.). Secondary metabolism is conditioned by differentiation; although the relationship between both has long remained elusive, differentiation as a trigger for antibiotic production remains basically unexplored. Most cultures used in screening campaigns for new bioactive molecules have been performed empirically, and workflow was extremely productive during the so-called golden age of antibiotics; however, currently there is a bottleneck. Streptomyces is still the most important natural source of antibiotics, and it also harbors many cryptic secondary metabolite pathways not expressed under laboratory conditions. In this chapter, we review strategies based on differentiation, one of the keys improving secondary metabolite production and activating cryptic pathways to face the challenges of drug discovery.
Download or read book Antimicrobials Antibiotic Resistance Antibiofilm Strategies and Activity Methods written by Sahra Kırmusaoğlu and published by BoD – Books on Demand. This book was released on 2019-04-03 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection. The goal of this book is to provide information on all these topics.
Download or read book Genetic Manipulation of Streptomyces written by D. A. Hopwood and published by . This book was released on 1985 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Actinomycetes written by Evi Stegmann and published by . This book was released on 2020-09-04 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Download or read book Natural Compounds as Antimicrobial Agents written by Carlos M. Franco and published by MDPI. This book was released on 2020-12-02 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is full of plants and animals that have their own defenses, producing various substances in their daily fight against bacteria, fungi, or other agents. These products are alternatives to conventional antimicrobials that have a poor reputation with consumers. Many of these compounds are well known; however, the multiple types of structures together with the variable responses depending of the type of biocontrol needed in a wide range of applications, such as clinical, agricultural, general hygiene, and food, necessitates the continuous search for specific applications and the continuous study of how to use these substances. The present book provides a summary of reviews and original research works that explore the multiple alternatives for the use of these compounds.
Download or read book Biology and Biotechnology of Actinobacteria written by Joachim Wink and published by Springer. This book was released on 2017-10-19 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.
Download or read book Lasso Peptides written by Yanyan Li and published by Springer. This book was released on 2014-10-21 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Download or read book Grand Challenges in Marine Biotechnology written by Pabulo H. Rampelotto and published by Springer. This book was released on 2018-05-15 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as essential reading for research scientists and biotechnologists from both academia and industry working in marine biotechnology and related disciplines. The book discusses recent advances and challenges in terms of science, technology, innovation, and policy for the development of the field; and how marine biotechnology may provide new solutions to some of the grand challenges faced by our society. Written in an accessible language, the book is also recommended as a reference text for decision-makers in government and non-governmental organizations in their efforts to foster the development of a global blue economy. With less than 5 % of the vast and rich marine environment explored, our seas and oceans represent a virtually unexplored resource for the discovery of novel product, processes, and development of bio-inspired synthetic drugs with biotechnological potential. As such, the marine environment has been considered Earth's last frontier of exploration. Recent advances in molecular techniques are providing the necessary tools to access on a larger scale the still-untapped ocean resources and, consequently, unveil the promise of the blue biotechnology. Governments are recognizing the potential of marine biotechnology to provide solutions to some of the Grand Challenges of the 21st Century such as sustainable energy and food sources, identification of novel drugs for improved health treatments, and providing new industrial materials and processes. For this reason, advances in marine biotechnology may foster the much-needed source of innovation and economic growth in many countries, and pave the way towards the development of a global blue economy, i.e. a new economic model based on the sustainable exploration of our ocean ecosystems.
Download or read book Streptomyces in Nature and Medicine written by D. A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Download or read book Psychrophiles From Biodiversity to Biotechnology written by Rosa Margesin and published by Springer. This book was released on 2017-06-22 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cold adaptation includes a complex range of structural and functional adaptations at the level of all cellular constituents, and these adaptations render cold-adapted organisms particularly useful for biotechnological applications. This book presents the most recent knowledge of (i) boundary conditions for microbial life in the cold, (ii) microbial diversity in various cold ecosystems, (iii) molecular cold adaptation mechanisms and (iv) the resulting biotechnological perspectives.
Download or read book Perspectives in Biotechnology and Applied Microbiology written by Daham I. Alani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon an invitation from Arab Bureau of Education for the Gulf States "ABEGS"; an International Conference on Biotechnology and Applied Microbiol ogy was held in Riyadh, Saudi Arabia, 12-15 November 1984. The Conference was sponsored by ABEGS and organized through coopera tion with Saudi Biological Society "SBS". ABEGS was established in 1976 with the aim of coordinating, unifying and developing all aspects of Education, Culture and Science in the Gulf States. In the field of publications, ABEGS is publishing various books, pamphlets and two scientific journals, one in Arabic and the other in English entitled: the Arab Gulf Journal of Scientific Research. This volume contains topics presented by the invited speakers and selected papers from among those submitted by participants. Selection was done on basis of some of the invited talks. Main topics of the conference were grouped into sections representing seven themes of Biotechnology and Applied Microbiology: - production of microbial proteins - utilization of microorganisms for the production of chemicals - microbial treatment and utilization of waste - continuous culture - application of biotechnology in plant science - applied microbiology and environment and - applied microbiology and biotechnology: international cooperation - tween developed and developing countries. Some of the topics in this volume present surveys of recent developments in several important areas of biotechnology and applied microbiology, while the remaining papers carry detailed research contributions.
Download or read book Basic Biology and Applications of Actinobacteria written by Shymaa Enany and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actinobacteria have an extensive bioactive secondary metabolism and produce a huge amount of naturally derived antibiotics, as well as many anticancer, anthelmintic, and antifungal compounds. These bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects.
Download or read book The Southern Pine Beetle written by Robert C. Thatcher and published by . This book was released on 1981 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drugs from the Sea written by Nobuhiro Fusetani and published by Karger Medical and Scientific Publishers. This book was released on 2000-01-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book consists of three parts: discovery, development and production of drugs from marine organisms. Marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks have attracted much attention as sources of potential drugs, which is described in the first part. A pain-killing drug developed from the venom of a cone shell is a recent highlight of marine natural product research; the interesting story of its discovery is provided. The second part features an anticancer drug with a novel mode of action which was originally isolated from a songe and a potential antiosteoporotic drug of a hexacoral origin. But the most serious problem for development of drugs from the sea remains supply. Two possible solutions, production by fermentation and by aquaculture, are described in the third part. Identification and culture of symbiotic bacteria which are responsible for the production of bioactive sponge metabolites are the main objectives for many researchers.
