Download or read book Continuous Discovery Habits written by Teresa Torres and published by Product Talk LLC. This book was released on 2021-05-19 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: "If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.

Download or read book Successful Strategies for the Discovery of Antiviral Drugs written by Manoj C. Desai and published by Royal Society of Chemistry. This book was released on 2013-06-17 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.

Download or read book Strategy for You written by Rich Horwath and published by Greenleaf Book Group. This book was released on 2012-01-24 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most people have spent their lives randomly bouncing around like bumper cars, never arriving at the life they want. If fact, new research shows that only 15 percent of adults have a plan for their life. But what if there was a way, a proven way, to experience more of what life has to offer?In "Strategy for You," world-renowned strategist Rich Horwath provides a proven plan for building the bridge to an exceptional life. Based on Horwath's ground-breaking work in the field of strategic thinking, the book helps readers apply the time-tested principles of business strategy to their lives. The author incorporates GOST (goals, objectives, strategies, tactics_, SWOT (strengths, weaknesses, opportunities, threats), and other business tools into a five-step plan that enables readers toDISCOVER the purpose in their lives

Download or read book Strategy Discovery written by Graham Kenny and published by Taylor & Francis. This book was released on 2023-09-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personal, useful, actionable and grounded in research, this book will shift your thinking from "strategy development" to "strategy discovery" to enable you to deal with today’s business challenges, engage your staff and boost your business performance. Management teams and boards are facing disruption on all sides, from morphing customer preferences to the COVID pandemic to climate change. At the same time they are floundering in strategy confusion with too many concepts and not enough clarity. In this book, strategy expert and regular Harvard Business Review author Graham Kenny releases managers and directors from their strategy haze. His simple and effective framework allows managers to navigate the current maze of ideas and approaches and maximize their competitive advantage. Kenny’s readable style is equally effective: each chapter begins with an engaging story, then builds on this with cases, client examples, sidebars and more, ending with a series of action points to provide a pathway to success. CEOs, senior-level and middle managers across all functions and sectors, including private, public and not-for-profit organizations, who discuss and set strategy for their organization or business unit will appreciate the articulated framework, illustrative anecdotes and positive encouragement this book offers.

Download or read book Prioritization of pathogens to guide discovery research and development of new antibiotics for drug resistant bacterial infections including tuberculosis written by and published by World Health Organization. This book was released on 2019-04-10 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Conceptual Development written by Ellin Kofsky Scholnick and published by Psychology Press. This book was released on 1999-04 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines a key issue in current cognitive theories - the nature of representation. Each chapter is characterized by attempts to frame hot topics in cognitive development within the landscape of current developmental theorizing and the past legacy of genetic epistemology. The chapters address four questions that are fundamental to any developmental line of inquiry: How should we represent the workings and contents of the mind? How does the child construct mental models during the course of development? What are the origins of these models? and What accounts for the novelties that are the products and producers of developmental change? These questions are situated in a historical context, Piagetian theory, and contemporary researchers attempt to trace how they draw upon, depart from, and transform the Piagetian legacy to revisit classic issues such as the child's awareness of the workings of mental life, the child's ability to represent the world, and the child's growing ability to process and learn from experience. The theoretical perspectives covered include constructivism, connectionism, theory-theory, information processing, dynamical systems, and social constructivist approaches. The research areas span imitation, mathematical reasoning, biological knowledge, language development, and theory of mind. Written by major contributors to the field, this work will be of interest to students and researchers wanting a brief but in-depth overview of the contemporary field of cognitive development.

Download or read book A Love of Discovery written by Robert G. Fuller and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Karplus, a professor of physics at the University of California, Berkeley, USA, became a leader in the movement to reform elementary school science in the 1960s. This book selects the enduring aspects of his work and presents them for the scientists and science educators of today. In an era when `science education for ALL students' has become the clarion call, the insights and works of Robert Karplus are as relevant now as they were in the 1960s, '70s, and '80s. This book tries to capture the essence of his life and work and presents selections of his published articles in a helpful context.

Download or read book The Incomplete Guide to the Art of Discovery written by Jack Ertle Oliver and published by . This book was released on 1991 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wonderful work, addressed to scientists but deserving of a wider audience. A personal, purposeful, and passionate exposition about the subjective process that accompanies discovery--and how to choose a discovery-laden topic for research, how to find opportunities in science overlooked by others, and how to break out of the rut of mundane thinking. Annotation copyrighted by Book News, Inc., Portland, OR

Download or read book Mathematical Cognition written by James M. Royer and published by IAP. This book was released on 2003-01-01 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pattern Detection and Discovery written by David J Hand and published by Springer. This book was released on 2003-08-02 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collation of large electronic databases of scienti?c and commercial infor- tion has led to a dramatic growth of interest in methods for discovering struc- res in such databases. These methods often go under the general name of data mining. One important subdiscipline within data mining is concerned with the identi?cation and detection of anomalous, interesting, unusual, or valuable - cords or groups of records, which we call patterns. Familiar examples are the detection of fraud in credit-card transactions, of particular coincident purchases in supermarket transactions, of important nucleotide sequences in gene sequence analysis, and of characteristic traces in EEG records. Tools for the detection of such patterns have been developed within the data mining community, but also within other research communities, typically without an awareness that the - sic problem was common to many disciplines. This is not unreasonable: each of these disciplines has a large literature of its own, and a literature which is growing rapidly. Keeping up with any one of these is di?cult enough, let alone keeping up with others as well, which may in any case be couched in an - familiar technical language. But, of course, this means that opportunities are being lost, discoveries relating to the common problem made in one area are not transferred to the other area, and breakthroughs and problem solutions are being rediscovered, or not discovered for a long time, meaning that e?ort is being wasted and opportunities may be lost.

Download or read book The Neurological Basis of Learning Development and Discovery written by Anton E. Lawson and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A goal of mine ever since becoming an educational researcher has been to help construct a sound theory to guide instructional practice. For far too long, educational practice has suffered because we have lacked firm instructional guidelines, which in my view should be based on sound psychological theory, which in turn should be based on sound neurological theory. In other words, teachers need to know how to teach and that "how-to-teach" should be based solidly on how people learn and how their brains function. As you will see in this book, my answer to the question of how people learn is that we all learn by spontaneously generating and testing ideas. Idea generating involves analogies and testing requires comparing predicted consequences with actual consequences. We learn this way because the brain is essentially an idea generating and testing machine. But there is more to it than this. The very process ofgenerating and testing ideas results not only in the construction of ideas that work (i. e. , the learning of useful declarative knowledge), but also in improved skill in learning (i. e. , the development of improved procedural knowledge).

Download or read book Discovery DMPK Quick Guide written by S. Cyrus Khojasteh and published by Springer Nature. This book was released on 2022-12-12 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.

Download or read book Ethnopharmacology and Drug Discovery for COVID 19 Anti SARS CoV 2 Agents from Herbal Medicines and Natural Products written by Jen-Tsung Chen and published by Springer Nature. This book was released on 2023-10-09 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".

Download or read book Towards translating research to clinical practice Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury written by Stefania Mondello and published by Frontiers Media SA. This book was released on 2015-02-25 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines.

Download or read book Structure based Drug Discovery written by Harren Jhoti and published by Springer Science & Business Media. This book was released on 2007-05-24 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Download or read book Collaborative Innovation in Drug Discovery written by Rathnam Chaguturu and published by John Wiley & Sons. This book was released on 2014-03-28 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's decline. Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships provides insight into the potential synergy of basing R&D in academia while leaving drug companies to turn hits into marketable products. As Founder and CEO of iDDPartners, focused on pharmaceutical innovation, Founding president of the International Chemical Biology Society, and Senior Director-Discovery Sciences, SRI International, Dr. Chaguturu has assembled a panel of experts from around the world to weigh in on issues that affect the two driving forces in medical advancement. Gain global perspectives on the benefits and potential issues surrounding collaborative innovation Discover how industries can come together to prevent another "Pharma Cliff" Learn how nonprofits are becoming the driving force behind innovation Read case studies of specific academia-pharma partnerships for real-life examples of successful collaboration Explore government initiatives that help foster cooperation between industry and academia Dr. Chaguturu’s thirty-five years of experience in academia and industry, managing new lead discovery projects and forging collaborative partnerships with academia, disease foundations, nonprofits, and government agencies lend him an informative perspective into the issues facing pharmaceutical progress. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, he and his expert team provide insight into the various nuances of the debate.

Download or read book Computational Methods in Drug Discovery and Repurposing for Cancer Therapy written by Ganji Purnachandra Nagaraju and published by Elsevier. This book was released on 2023-03-22 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability. The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others. This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients. - Discusses in silico remodeling of effective phytochemical compounds for discovering improved anticancer agents for substantial/significant cancer therapy - Covers potential tools of bioinformatics that are applied toward discovering new targets by drug repurposing and strategies to cure different types of cancers - Demonstrates the significance of computational and artificial intelligence approaches in anticancer drug discovery - Explores how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care