Download or read book Stochastic and State Space Models of Carcinogenesis with Applications written by Lijun Zhang and published by . This book was released on 2008 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stochastic Models With Applications To Genetics Cancers Aids And Other Biomedical Systems Second Edition written by Wai-yuan Tan and published by World Scientific. This book was released on 2015-10-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic treatment of Markov chains, diffusion processes and state space models, as well as alternative approaches to Markov chains through stochastic difference equations and stochastic differential equations. It illustrates how these processes and approaches are applied to many problems in genetics, carcinogenesis, AIDS epidemiology and other biomedical systems.One feature of the book is that it describes the basic MCMC (Markov chain and Monte Carlo) procedures and illustrates how to use the Gibbs sampling method and the multilevel Gibbs sampling method to solve many problems in genetics, carcinogenesis, AIDS and other biomedical systems.As another feature, the book develops many state space models for many genetic problems, carcinogenesis, AIDS epidemiology and HIV pathogenesis. It shows in detail how to use the multilevel Gibbs sampling method to estimate (or predict) simultaneously the state variables and the unknown parameters in cancer chemotherapy, carcinogenesis, AIDS epidemiology and HIV pathogenesis. As a matter of fact, this book is the first to develop several state space models for many genetic problems, carcinogenesis and other biomedical problems.To emphasize special applications to medical problems, in this new edition the book has added a new chapter to illustrate how to develop biologically-supported stochastic models and state space models of carcinogenesis in human beings. Specific examples include hidden Markov models and state space models for human colon cancer, human liver cancer and some human pediatric cancers such as retinoblastoma and hepatoblastoma. The book also gives examples to illustrate how to develop procedures to assess cancer risk of environmental agents through initiation-promotion protocols.

Download or read book Stochastic Models with Applications to Genetics Cancers AIDS and Other Biomedical Systems written by W. Y. Tan and published by World Scientific. This book was released on 2002 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic treatment of Markov chains, diffusion processes and state space models, as well as alternative approaches to Markov chains through stochastic difference equations and stochastic differential equations. It illustrates how these processes and approaches are applied to many problems in genetics, carcinogenesis, AIDS epidemiology and other biomedical systems.One feature of the book is that it describes the basic MCMC (Markov chain and Monte Carlo) procedures and illustrates how to use the Gibbs sampling method and the multilevel Gibbs sampling method to solve many problems in genetics, carcinogenesis, AIDS and other biomedical systems.As another feature, the book develops many state space models for many genetic problems, carcinogenesis, AIDS epidemiology and HIV pathogenesis. It shows in detail how to use the multilevel Gibbs sampling method to estimate (or predict) simultaneously the state variables and the unknown parameters in cancer chemotherapy, carcinogenesis, AIDS epidemiology and HIV pathogenesis. As a matter of fact, this book is the first to develop many state space models for many genetic problems, carcinogenesis and other biomedical problems.

Download or read book Stochastic Models with Applications to Genetics Cancers AIDS and Other Biomedical Systems second Edition written by W. Y. Tan and published by World Scientific. This book was released on 2015-10-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book presents a systematic treatment of Markov chains, diffusion processes and state space models, as well as alternative approaches to Markov chains through stochastic difference equations and stochastic differential equations. It illustrates how these processes and approaches are applied to many problems in genetics, carcinogenesis, AIDS epidemiology and other biomedical systems. One feature of the book is that it describes the basic MCMC (Markov chain and Monte Carlo) procedures and illustrates how to use the Gibbs sampling method and the multilevel Gibbs sampling method to solve many problems in genetics, carcinogenesis, AIDS and other biomedical systems. As another feature, the book develops many state space models for many genetic problems, carcinogenesis, AIDS epidemiology and HIV pathogenesis. It shows in detail how to use the multilevel Gibbs sampling method to estimate (or predict) simultaneously the state variables and the unknown parameters in cancer chemotherapy, carcinogenesis, AIDS epidemiology and HIV pathogenesis. As a matter of fact, this book is the first to develop several state space models for many genetic problems, carcinogenesis and other biomedical problems. To emphasize special applications to medical problems, in this new edition the book has added a new chapter to illustrate how to develop biologically-supported stochastic models and state space models of carcinogenesis in human beings. Specific examples include hidden Markov models and state space models for human colon cancer, human liver cancer and some human pediatric cancers such as retinoblastoma and hepatoblastoma. The book also gives examples to illustrate how to develop procedures to assess cancer risk of environmental agents through initiation-promotion protocols."--

Download or read book Stochastic and State Space Models in Carcinogenesis and Cell Populations written by Wei Wang and published by . This book was released on 2000 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stochastic and State Space Models of Carcinogenesis Under Complex Situation written by Xiaowei Yan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With more and more biological mechanisms of cancer development being discovered, in order to improve cancer control and prevention, it becomes necessary to develop effective and efficient mathematical and statistical models and methods to incorporate the biological information, and to identify critical events in the process of carcinogenesis. In this dissertation, the complex nature of carcinogenesis has been represented by stochastic system model; combining this model with information from observations and prior knowledge, we have developed state space models to evaluate cancer gene mutations and cell proliferation at different cancer development stages. Also, we have proposed a generalized Bayesian method via multi-level Gibbs sampling procedure to predict state (stage) variables of the models. In this dissertation, stochastic models have been proposed for initiation, promotion and complete carcinomas experiments; these experiments are most commonly performed in cancer risk assessment of environmental agents. These stochastic models are simple multi-pathway models which are constructed based on biological mechanisms. The estimates we obtained from the models have provided quantitative evaluation of dose related mutation rates of major genes and cells proliferation rates; these results could be used to assess the risk of developing malignant tumor in the environment we live. More complicated stochastic and state space models have been developed for sporadic human colon cancer and for hereditary and non-hereditary human liver cancer. We have utilized the proposed models to fit to Surveillance Epidemiology and End Results (SEER) data. The results imply that our models have effectively incorporated biological information and observations; these models fitted the data very well and the inferences based on estimate were very consistent with biological findings. Furthermore, the models reflected the complex nature of carcinogenesis. We notice that many cancers are developed through multiple-stage multiple-pathway. Our analyses of colon cancer and liver cancer have showed that some pathways are more devastated than others. This suggests thus it would be more efficient to intervene or treat the critical events in the more devastated pathways. .

Download or read book Stochastic Models for Carcinogenesis written by Wai-Yuan Tan and published by CRC Press. This book was released on 2020-01-31 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date survey of mathematical models of carcinogenesis, providing the most recent findings of cancer biology as evidence of the models, as well as extensive bibliographies of cancer biology and in-depth mathematical analyses for each of the models. May be used as a reference for biostaticians, biometricians, mathematical and molecular biologists, applied mathematicians, oncologists, cancer and toxicology researchers, environmental scientists, and graduate students in these fields.

Download or read book Handbook of Cancer Models with Applications written by W. Y. Tan and published by World Scientific. This book was released on 2008 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.

Download or read book Handbook Of Cancer Models With Applications written by Wai-yuan Tan and published by World Scientific. This book was released on 2008-06-02 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.

Download or read book Methods and Applications of Statistics in the Life and Health Sciences written by Narayanaswamy Balakrishnan and published by John Wiley & Sons. This book was released on 2009-12-02 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inspired by the Encyclopedia of Statistical Sciences, Second Edition, this volume outlines the statistical tools for successfully working with modern life and health sciences research Data collection holds an essential part in dictating the future of health sciences and public health, as the compilation of statistics allows researchers and medical practitioners to monitor trends in health status, identify health problems, and evaluate the impact of health policies and programs. Methods and Applications of Statistics in the Life and Health Sciences serves as a single, one-of-a-kind resource on the wide range of statistical methods, techniques, and applications that are applied in modern life and health sciences in research. Specially designed to present encyclopedic content in an accessible and self-contained format, this book outlines thorough coverage of the underlying theory and standard applications to research in related disciplines such as biology, epidemiology, clinical trials, and public health. Uniquely combining established literature with cutting-edge research, this book contains classical works and more than twenty-five new articles and completely revised contributions from the acclaimed Encyclopedia of Statistical Sciences, Second Edition. The result is a compilation of more than eighty articles that explores classic methodology and new topics, including: Sequential methods in biomedical research Statistical measures of human quality of life Change-point methods in genetics Sample size determination for clinical trials Mixed-effects regression models for predicting pre-clinical disease Probabilistic and statistical models for conception Statistical methods are explored and applied to population growth, disease detection and treatment, genetic and genomic research, drug development, clinical trials, screening and prevention, and the assessment of rehabilitation, recovery, and quality of life. These topics are explored in contributions written by more than 100 leading academics, researchers, and practitioners who utilize various statistical practices, such as election bias, survival analysis, missing data techniques, and cluster analysis for handling the wide array of modern issues in the life and health sciences. With its combination of traditional methodology and newly developed research, Methods and Applications of Statistics in the Life and Health Sciences has everything students, academics, and researchers in the life and health sciences need to build and apply their knowledge of statistical methods and applications.

Download or read book Quantitative Medical Data Analysis Using Mathematical Tools And Statistical Techniques written by Don Hong and published by World Scientific. This book was released on 2007-07-10 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative biomedical data analysis is a fast-growing interdisciplinary area of applied and computational mathematics, statistics, computer science, and biomedical science, leading to new fields such as bioinformatics, biomathematics, and biostatistics. In addition to traditional statistical techniques and mathematical models using differential equations, new developments with a very broad spectrum of applications, such as wavelets, spline functions, curve and surface subdivisions, sampling, and learning theory, have found their mathematical home in biomedical data analysis.This book gives a new and integrated introduction to quantitative medical data analysis from the viewpoint of biomathematicians, biostatisticians, and bioinformaticians. It offers a definitive resource to bridge the disciplines of mathematics, statistics, and biomedical sciences. Topics include mathematical models for cancer invasion and clinical sciences, data mining techniques and subset selection in data analysis, survival data analysis and survival models for cancer patients, statistical analysis and neural network techniques for genomic and proteomic data analysis, wavelet and spline applications for mass spectrometry data preprocessing and statistical computing.

Download or read book A Stochastic Model for Immunological Feedback in Carcinogenesis Analysis and Approximations written by N. Dubin and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stochastic processes often pose the difficulty that, as soon as a model devi ates from the simplest kinds of assumptions, the differential equations obtained for the density and the generating functions become mathematically formidable. Worse still, one is very often led to equations which have no known solution and don't yield to standard analytical methods for differential equations. In the model considered here, one for tumor growth with an immunological re sponse from the normal tissue, a nonlinear term in the transition probability for the death of a tumor cell leads to the above-mentioned complications. Despite the mathematical disadvantages of this nonlinearity, we are able to consider a more sophisticated model biologically. Ultimately, in order to achieve a more realistic representation of a complicated phenomenon, it is necessary to examine mechanisms which allow the model to deviate from the more mathematically tractable linear format. Thus far, stochastic models for tumor growth have almost exclusively considered linear transition probabilities.

Download or read book Endocrine Disrupters and Carcinogenic Risk Assessment written by Lech Chyczewski and published by IOS Press. This book was released on 2002 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of biologically-based risk assessment, as developed form physiologically-based toxicokinetic models. The analysis of this material is proposed as the novel parameters for developing biologically-based models of carcinogenesis, considered to be more relevant to risk assessment than traditional approaches.

Download or read book A Stochastic Model for Carcinogenesis with Special Applications to the Initiation and Promotion Phenomena written by Maria Teresa C. Gastardo and published by . This book was released on 1984 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment written by Lutz Edler and published by John Wiley & Sons. This book was released on 2005-12-13 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendium of state-of-the-art methods proposed and used, featuring contributions from eminent authors with varied experience from academia, government, and industry. Provides a comprehensive summary of currently available quantitative methods for risk assessment of both cancer and non-cancer problems. Describes the applications and the limitations of current mathematical modelling and statistical analysis methods (classical and Bayesian). Includes an extensive introduction and discussion to each chapter. Features detailed studies of risk assessments using biologically-based modelling approaches. Discusses the varying computational aspects of the methods proposed. Provides a global perspective on human health risk assessment by featuring case studies from a wide range of countries. Features an extensive bibliography with links to relevant background information within each chapter. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment will appeal to researchers and practitioners in public health & epidemiology, and postgraduate students alike. It will also be of interest to professionals working in risk assessment agencies.

Download or read book Applications of Stochastic Models for the Analysis of the Mechanisms of Carcinogenesis written by and published by . This book was released on 1964 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Information Resources in Toxicology Volume 1 Background Resources and Tools written by Steve Gilbert and published by Academic Press. This book was released on 2020-05-16 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals Explores recent internet trends, web-based databases, and software tools in a section on the online environment Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field