Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Download or read book 8 Membered Heterocycle Synthesis written by Navjeet Kaur and published by Elsevier. This book was released on 2023-02-21 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: 8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent. Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals. - Covers the different methodologies for the synthesis of eight-membered heterocycles - Includes summary schemes for each type of heterocycle, giving an overview of all the reactants that can be used, and the experimental conditions - Includes discussion of the applications of eight-membered heterocycles

Download or read book Stereocontrolled Routes to Trisubstituted Cyclic Ethers written by Christopher Patrick Holmes and published by . This book was released on 1986 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stereoselective Multiple Bond Forming Transformations in Organic Synthesis written by Jean Rodriguez and published by John Wiley & Sons. This book was released on 2015-04-03 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining the important research topic of multiple bond-formingtransformations with green chemistry, this book helps chemistsidentify recent sustainable stereoselective syntheticsequences. • Combines the important research topic ofmultiple bond-forming transformations with green chemistry andsustainable development • Offers a valuable resource for preparingcompounds with multiple stereogenic centers, an important field forsynthetic chemists • Organizes chapters by molecular structureof final products, making for a handbook-style resource • Discusses applications of the synthesisof natural products and of drug intermediates • Brings together otherwise-scatteredinformation about a number of key, efficient chemical reactions

Download or read book Classics in Stereoselective Synthesis written by Erick M. Carreira and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.

Download or read book Comprehensive Organic Functional Group Transformations written by Alan R. Katritzky and published by Elsevier. This book was released on 2003-03-21 with total page 1380 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Volume, containing 24 chapters devoted to carbon attached by single bonds to two heteroatoms, the reader will find several chapters reviewing the synthesis of familiar functional groups, notably acetals, dithioacetals, aminals and the various mixed species. The derivatives with tetracoordinated (saturated) carbon are described in Part I and those, eg. ketene acetals, of tricoordinated carbon in Part II. However, the treatment is comprehensive and the authors have uncovered much fascinating chemistry concerning less familiar groups, including some like geminal halohydrins, halo amines and diols that are often unstable. Again, a surprisingly large number of compounds having two metals attached to the same carbon have been located in the literature, and the abundance of phosphorus derivatives, eg. those with geminal nitrogen functions, reflects their importance as biologically active species and as intermediates in synthesis. Part III consists of a single, short chapter describing dicoordinate carbon (carbenes) and examples of carbon cations, anions and radicals. Here the treatment is deliberately selective since throughout the work as a whole emphasis is placed on the synthesis of isolable species rather than the transient intermediates of organic reactions.

Download or read book Organic Synthesis Highlights written by Hans-Josef Altenbach and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unusual collection of 49 essays gives an overview of the trends and accomplishments of synthetic organic chemistry in recent years. Unique in its approach, it deals with almost every aspect of modern synthesis. The first part of the book describes methods and reagents, with particular emphasis on rapidly developing organometallic and biooriented procedures. In the second part, these tools are applied to the syntheses of interesting target compounds and natural compounds with remarkable physiological properties. Mechanistic discussions and retrosynthetic analyses are included. More than 1000 up-to-date references help the reader to pursue the topics highlighted here. This book gives both the active researcher and the advanced student insight into the competitive atmosphere, creativity, and resourcefulness so characteristic of organic synthesis today.

Download or read book The Organic Chemistry of Sugars written by Daniel E. Levy and published by CRC Press. This book was released on 2005-09-21 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst

Download or read book Side Reactions in Organic Synthesis written by Florencio Zaragoza Dörwald and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates

Download or read book Science of Synthesis Houben Weyl Methods of Molecular Transformations Vol 29 written by Stuart Warriner and published by Thieme. This book was released on 2014-05-14 with total page 2246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series, Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008. Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy. Contains the expertise of presently 400 leading chemists worldwide Critically evaluates the preparative applicability and significance of the synthetic methods Discusses relevant background information and provides detailed experimental procedures For full information on the Science of Synthesis series, visit the Science of Synthesis Homepage.

Download or read book Index Volume Category 5 written by Jutta Backes and published by Thieme. This book was released on 2014-05-14 with total page 2871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab. The content of this e-book was originally published in December 2009.

Download or read book Modern Enolate Chemistry written by Manfred Braun and published by John Wiley & Sons. This book was released on 2016-02-23 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by one of the world?s leading synthetic chemists in the field, this reference presents modern enolate chemistry with an emphasis on metal O-enolates in asymmetric synthesis. While great care is taken to cover novel, successful concepts, such classical methods as the famous Evans enolates are equally highlighted. Throughout the book representative reaction procedures are presented, thus helping readers to find the best solution for their own synthetic problem. Of high interest to synthetic chemists in academia, as well as the pharmaceuticals, agrochemicals and fine chemicals industries.

Download or read book Cyclization Reactions written by C. Thebtaranonth and published by CRC Press. This book was released on 1993-05-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclization Reactions provides a quick update of the latest advances in cyclization reactions. It covers the basic principles of cyclization chemistry, emphasizing practical applications. Chapters are organized according to the different cyclization intermediates-cationic, radical, anionic, and metal complex intermediates. The last chapter covers macrolactonization, vicinal tricarbonal, and Bergman (enediyne) reactions, which are of particular interest today. More than 2,600 structures illustrate key concepts throughout the book. Various cyclizations are organized into mechanistic groups to help researchers choose and change between methods when searching for maximum efficiency in synthesis. Critical coverage of the literature up to 1992 is provided. Cyclization Reactions is essential reading for anyone involved in the synthesis of ring compounds or who is seeking a rapid overview of the field. Newcomers as well as experienced researchers will benefit from this book. It also is excellent reference material for students at the advanced undergraduate and graduate levels.

Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field

Download or read book Quaternary Ammonium Salts written by R. Alan Jones and published by Elsevier. This book was released on 2000-11-14 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides experimental methods for a wide range of organic reactions, systematically arranged according to reaction type, and describes the advantages and limitations of the procedures. Traditional methods to speed up organic reactions involve energy-consuming processes and costly and environmentally "unfriendly" solvents. Additionally, isolation of the product requires energy and time-consuming purification processes. A simple solution, especially for reactions involving anionic reactants, is the use of phase-transfer catalysis. Quaternary ammonium cations have the ability to transfer the anionic reactants as non-solvated ion-pairs from aqueous media into organic media. The resultant effect is to increase the rate of the organic reaction by enhancing the reactivity of the anionic species and increasing the encounter rate with the organic substrate. Side reactions are frequently eliminated so that the overall yield of the desired product is increased.Quaternary Ammonium Salts presents procedures for reducing reaction times and the need for extreme conditions, which are frequently encountered under standard reaction procedures.This is the only book to be published on quaternary ammonium salts. Best Synthetic Methods volumes allow the practicing synthetic chemist to choose between all the alternatives and assess their real advantages and limitations. Each volume of the series deals with a particular topic from a practical point of view, giving detailed examples and precise experimental directions and hints. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry.

Download or read book Organic Chemistry Study Guide written by Robert J. Ouellette and published by Elsevier. This book was released on 2014-11-04 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry Study Guide: Key Concepts, Problems, and Solutions features hundreds of problems from the companion book, Organic Chemistry, and includes solutions for every problem. Key concept summaries reinforce critical material from the primary book and enhance mastery of this complex subject. Organic chemistry is a constantly evolving field that has great relevance for all scientists, not just chemists. For chemical engineers, understanding the properties of organic molecules and how reactions occur is critically important to understanding the processes in an industrial plant. For biologists and health professionals, it is essential because nearly all of biochemistry springs from organic chemistry. Additionally, all scientists can benefit from improved critical thinking and problem-solving skills that are developed from the study of organic chemistry. Organic chemistry, like any "skill", is best learned by doing. It is difficult to learn by rote memorization, and true understanding comes only from concentrated reading, and working as many problems as possible. In fact, problem sets are the best way to ensure that concepts are not only well understood, but can also be applied to real-world problems in the work place. - Helps readers learn to categorize, analyze, and solve organic chemistry problems at all levels of difficulty - Hundreds of fully-worked practice problems, all with solutions - Key concept summaries for every chapter reinforces core content from the companion book

Download or read book Au Catalyzed Synthesis and Functionalization of Heterocycles written by Marco Bandini and published by Springer. This book was released on 2016-07-01 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal