Download or read book Stem Cell Microenvironments and Beyond written by Alexander Birbrair and published by Springer. This book was released on 2017-12-03 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

Download or read book Translational Stem Cell Research written by Kristina Hug and published by Springer Science & Business Media. This book was released on 2010-12-25 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications. Translational Stem Cell Research is broken into ten sections. It opens with an overview of the latest in stem cell research, focusing on specific diseases and the treatment of burn victims. Part II discusses the issues involved in the many steps from bench to bedside, ranging from first research in vitro to clinical trials. Part III covers scientific, regulatory and ethical challenges to basic research, and Part IV details issues regarding stem cell banks. Part V explores ethical, economic and strategic issues involved in collaboration between universities and industry, and Part VI addresses legal problems raised by patents on human stem-cell based inventions plus the extent to which there can be technological solutions to a moral dilemma. Part VII presents imaginative ways of communicating research to the general public and how to create conditions for a constructive dialogue. Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees. The book closes with a look into the future of translational stem cell research and stem cell-based therapeutic applications.

Download or read book Stem Cells written by Suchandra Chowdhury and published by Springer Nature. This book was released on 2021-07-24 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

Download or read book Stem Cell Battles written by D. O. N. C. REED and published by World Scientific. This book was released on 2015-10-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a one-of-a-kind book: combining easy-to-understand science, in-the-trenches political warfare, and inspirational stories. It aims to give hope to individuals and families who suffer from chronic disease or disability; to point out how ordinary people can make an extraordinary difference in the battle to ease suffering and save lives through supporting medical research; to share in "people talk" some of the amazing progress already achieved in the new field of stem cell research; to show how even such a magnificent success as the California stem cell program is under constant attack from ideological groups; to offer medical research as a force for international cooperation; to suggest how cure research lessens the need for the mountainous costs of endless care.Unparalleled background: the author has been involved in virtually every important stem cell battle (state, national, and international) since embryonic stem cell research began. The author works closely with Robert N. Klein, sponsor of the California stem cell program, the largest source of such stem cell research funding in the world. In addition, the author is an award-winning teacher as well as writer, and seeks to entertain as well as educate. His book is not only substantive, but also fun.The book would be a treasured gift: for anyone suffering an "incurable" illness or who is a caregiver for a loved one; for a college student considering a rewarding career in biomedicine; for scientists who want to protect and enhance their research funding; and for anyone who wants to see government respond to the needs of its citizenry. Chronic disease and disability are a prison: cure is the triumphant escape -- wheelchairs should be for temporary occupancy only.

Download or read book Engineering Bio inspired Microenvironments for Stem Cell Proliferation and Skeletal Differentiation written by Yongsung Hwang and published by . This book was released on 2011 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions of cells with their extracellular matrix (ECM) play an important role in development, disease progression, and regeneration. The material properties of ECM such as geometry, chemistry, hydrophobicity, mechanics, and microstructure play an important role in regulating various cellular processes and tissue morphogenesis. Thus there is a surge of interest in determining the effect of various material properties on cell fate and tissue formation. Beyond providing fundamental understandings, these efforts can also led to development of effective scaffolds (structural support for cell culture) as scaffold engineering is an integral part of in vitro cell cultures, tissue engineering, and transplants/implants. The central focus of this thesis is design of polymer-based biomaterials as synthetic matrices for cell culture and understands how cell-matrix interactions affect tissue formation, stem cell differentiation and self-renewal. The first two chapters focuses on synthesis and characterization of three dimensional hydrogels having interconnected macroporous network structures of poly(ethylene glycol) using cryogelation techniques, where I have developed a novel, green strategy to create monolithic structures with heterogeneous and homogenous networks. I have also developed a process to create three-dimensional structures with different internal architecture while maintaining the same porosity. These 3D structures were then used to understand effect of scaffold porosity, pore structure, etc play an important role in cell proliferation, differentiation, and tissue formation using cartilage tissue engineering as a model system. We also harnessed the potential of cell-matrix interactions to develop defined, synthetic matrices to expand human embryonic stem cells in vitro without introducing any detrimental effects. Employing a number of hydrogels I have determined the effect of various physico-chemical cues (bulk and interfacial properties) on adhesion, growth, colony formation, and self-renewal of human embryonic stem cells. Poly[acrylamide-co-sodium 4-vinylbenzenesulfonate] hydrogels having a moderate hydrophobicity (water contact angle of 23°) and bulk rigidity of 343.7kPa have supported in vitro growth of a number of hPSCs (HUES9, HUES6, and iPSCs) in defined medium (StemPro®) for more than 20 passages. These studies are discussed in chapter 4.

Download or read book Stem Cell Research in Asia written by Margaret Sleeboom-Faulkner and published by Routledge. This book was released on 2016-03-22 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The great hurry to realise promised cures in stem cell research requires regulation to guarantee bioethical research practices. Yet, increasingly similar national guidelines for stem cell research yields a range of diverging research practices. This book shows how the different rationale of regulation affects stem cell research practices in Asia. In low- and medium income countries such as India and China the advancement of science has a different weight on the national agenda, and the evaluation of scientific research is measured with a different yardstick, depending on the political and national research environment. For developing countries the question of research funding into stem cell research, healthcare, and the donation of embryos, foetuses and oocytes entail different considerations compared to in affluent welfare societies. Moreover, research institutions have different cultural and political histories, so that the meaning of formal guidelines, legislation and social rules may differ according to their various institutional settings. This volume discusses the informal cultures, social conventions and traditions that are crucial to the way in which stem cell research takes place in Asia. This book was originally published as a special issue of New Genetics and Society.

Download or read book Microenvironment Derived Stem Cell Plasticity written by Jelena Krstic and published by Frontiers Media SA. This book was released on 2017-12-21 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.

Download or read book The Stem Cell Microenvironment and Its Role in Regenerative Medicine and Cancer Pathogenesis written by Cristian Pablo Pennisi and published by CRC Press. This book was released on 2022-09-01 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation. This book discusses some of the recent advances in stem cell research that may help understanding the properties of the niche that govern stem cell fate. Technical topics discussed include:Stem cell biologyCancer stem cellsStem cell interactions with biomaterialsEngineering the stem cell microenvironmentStem cells in tissue regeneration and repairThe Disputationes Workshop series is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. This book emerges as a result of the scientific contributions presented and discussed during the fifth Disputationes Workshop held in Aalborg (Denmark) in April 2014. The stem cell microenvironment and its role in regenerative medicine and cancer pathogenesis is ideal for academic staff and master/research students in biomedical and health sciences

Download or read book Trends in Stem Cell Proliferation and Cancer Research written by Rodrigo R. Resende and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Download or read book Stem Cells and Cell Therapy written by Mohamed Al-Rubeai and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Download or read book Microenvironment Derived Stem Cell Plasticity written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.

Download or read book Hope Beyond Hype written by Ken MacLeod and published by . This book was released on 2012 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stem Cells Exosomes and Beyond written by Dmitry Arbuck and published by . This book was released on 2022-06-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell science is one of the most misunderstood areas of modern medicine. It is surrounded by myths, confusion, and strong opinions that vary from blind belief to complete rejection. This book was written as a review of the developing field with the goal of giving interested doctors and patients a foundation of future fluency. It addresses existing controversies and identifies possible roads to the practical use of stem cells, exosomes, and the active ingredients they synthesize and carry. Readers will learn that modern stem cell treatments are not about embryos, cancer, or the other things they may have been afraid of in the past.The history of stem cell use, the nature of regenrative biologics, and the possible risks and benefits of regenerative medicine are reviewed. The ways the stem cell industry is regulated, the safeguards in place, and how current research is reported are all covered. You will learn that there are many types of stem cell products available and that they differ deeply. We will examine PRP, amniotic fluid, amniotic membrane, fat and bone marrow stem cells, umbilical blood and wall stem cells, and adult stem cells. We also look at exosomes and cell-to-cell interactions. This Third Edition adds updated content and many new and expanded chapters, including regulatory environment changes and other topics.Stem cell science is rich in discoveries, curiosities, possibilities, and pitfalls. There are thousands of studies going on in the US and around the world. Stem Cell treatment holds incredible promise, which may be realized only with diligent research. Neither excessive optimism nor unwarranted pessimism is welcome in medicine. We are at the beginning of a healthcare revolution that will utilize many ways to treat diseases. Stem cell related regenerative treatment is one of these ways to improve life.

Download or read book The Cell secreted Microenvironment written by Laralynne Michelle Przybyla and published by . This book was released on 2012 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this work is to obtain an in depth understanding of how embryonic stem cell-secreted signals contribute to their identity. We analyze the contribution of broad and specific signals present in the cell-secreted microenvironment using techniques that can easily be applied to studies of other cell types and signaling systems. Determining the effects of external signals produced endogenously by stem cells is important for understanding fundamental biological processes regarding cell communication and for implementing more sophisticated manipulation protocols for future clinical applications. Harnessing the ability of stem cells to generate specific cell types is necessary for many regenerative medicine and tissue engineering applications and would be enhanced by a more thorough understanding of the signaling pathways required to maintain stem cell self-renewal and to initiate an exit from the self-renewing state. In this thesis, we describe work showing that mouse embryonic stem cell (mESC)-secreted signals are required to maintain self-renewal, as cells enter a primed, epiblast-like state of early differentiation when microfluidic perfusion is used to deplete soluble cell-secreted signals. We show that this phenotypic change can be used to our advantage for directed differentiation, and further demonstrate that remodeling the endogenous extracellular matrix halts the exit from the self-renewing state that occurs in mESCs growing under perfusion. Matrix remodeling is then shown to be both necessary and sufficient for maintaining mouse embryonic stem cell self-renewal in the absence of other external cues, and we demonstrate a method for assessing the relative contributions of soluble versus matrix-based cues. Together, our data indicate the importance of mESC-secreted factors in contributing to cell survival, self-renewal, and differentiation in normal cultures. Beyond furthering our understanding of intrinsic signaling mechanisms, this information can be used to devise better culture systems for directed differentiation of pluripotent cells. In addition, the techniques developed and implemented here for assessing the contributions of endogenous signals can all be applied generally to any adherent cell type for studies of how the cell-secreted microenvironment contributes to signaling processes and ultimately to cell phenotype.

Download or read book Hope Beyond Hype written by Barbara Melville and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Cancer Stem Cell Niche written by Susie Nilsson and published by Academic Press. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Download or read book Translational Stem Cell Research written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: