Download or read book Statistics in Toxicology Using R written by Ludwig A. Hothorn and published by CRC Press. This book was released on 2016-01-13 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysi

Download or read book Regulatory Toxicology written by Franz-Xaver Reichl and published by Springer. This book was released on 2014-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Download or read book Statistical Methods in Toxicology written by Ludwig Hothorn and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

Download or read book Statistical Analysis of Ecotoxicity Studies written by John W. Green and published by John Wiley & Sons. This book was released on 2018-08-14 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.

Download or read book Statistics for Toxicologists written by Salsburg and published by CRC Press. This book was released on 1986-05-29 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how the computer programs work and why and when they can be applied to problems in toxicology. It discusses the statistical models used and their applications in a general fashion. The book overviews the problems that can arise from the blind use of the statistical models.

Download or read book Analyzing Baseball Data with R Second Edition written by Jim Albert and published by CRC Press. This book was released on 2018-11-19 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzing Baseball Data with R Second Edition introduces R to sabermetricians, baseball enthusiasts, and students interested in exploring the richness of baseball data. It equips you with the necessary skills and software tools to perform all the analysis steps, from importing the data to transforming them into an appropriate format to visualizing the data via graphs to performing a statistical analysis. The authors first present an overview of publicly available baseball datasets and a gentle introduction to the type of data structures and exploratory and data management capabilities of R. They also cover the ggplot2 graphics functions and employ a tidyverse-friendly workflow throughout. Much of the book illustrates the use of R through popular sabermetrics topics, including the Pythagorean formula, runs expectancy, catcher framing, career trajectories, simulation of games and seasons, patterns of streaky behavior of players, and launch angles and exit velocities. All the datasets and R code used in the text are available online. New to the second edition are a systematic adoption of the tidyverse and incorporation of Statcast player tracking data (made available by Baseball Savant). All code from the first edition has been revised according to the principles of the tidyverse. Tidyverse packages, including dplyr, ggplot2, tidyr, purrr, and broom are emphasized throughout the book. Two entirely new chapters are made possible by the availability of Statcast data: one explores the notion of catcher framing ability, and the other uses launch angle and exit velocity to estimate the probability of a home run. Through the book’s various examples, you will learn about modern sabermetrics and how to conduct your own baseball analyses. Max Marchi is a Baseball Analytics Analyst for the Cleveland Indians. He was a regular contributor to The Hardball Times and Baseball Prospectus websites and previously consulted for other MLB clubs. Jim Albert is a Distinguished University Professor of statistics at Bowling Green State University. He has authored or coauthored several books including Curve Ball and Visualizing Baseball and was the editor of the Journal of Quantitative Analysis of Sports. Ben Baumer is an assistant professor of statistical & data sciences at Smith College. Previously a statistical analyst for the New York Mets, he is a co-author of The Sabermetric Revolution and Modern Data Science with R.

Download or read book Introduction to Statistics Through Resampling Methods and R written by Phillip I. Good and published by John Wiley & Sons. This book was released on 2013-02-11 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly accessible alternative approach to basic statistics Praise for the First Edition: "Certainly one of the most impressive little paperback 200-page introductory statistics books that I will ever see . . . it would make a good nightstand book for every statistician."—Technometrics Written in a highly accessible style, Introduction to Statistics through Resampling Methods and R, Second Edition guides students in the understanding of descriptive statistics, estimation, hypothesis testing, and model building. The book emphasizes the discovery method, enabling readers to ascertain solutions on their own rather than simply copy answers or apply a formula by rote. The Second Edition utilizes the R programming language to simplify tedious computations, illustrate new concepts, and assist readers in completing exercises. The text facilitates quick learning through the use of: More than 250 exercises—with selected "hints"—scattered throughout to stimulate readers' thinking and to actively engage them in applying their newfound skills An increased focus on why a method is introduced Multiple explanations of basic concepts Real-life applications in a variety of disciplines Dozens of thought-provoking, problem-solving questions in the final chapter to assist readers in applying statistics to real-life applications Introduction to Statistics through Resampling Methods and R, Second Edition is an excellent resource for students and practitioners in the fields of agriculture, astrophysics, bacteriology, biology, botany, business, climatology, clinical trials, economics, education, epidemiology, genetics, geology, growth processes, hospital administration, law, manufacturing, marketing, medicine, mycology, physics, political science, psychology, social welfare, sports, and toxicology who want to master and learn to apply statistical methods.

Download or read book Spatial Microsimulation with R written by Robin Lovelace and published by CRC Press. This book was released on 2017-09-07 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generate and Analyze Multi-Level Data Spatial microsimulation involves the generation, analysis, and modeling of individual-level data allocated to geographical zones. Spatial Microsimulation with R is the first practical book to illustrate this approach in a modern statistical programming language. Get Insight into Complex Behaviors The book progresses from the principles underlying population synthesis toward more complex issues such as household allocation and using the results of spatial microsimulation for agent-based modeling. This equips you with the skills needed to apply the techniques to real-world situations. The book demonstrates methods for population synthesis by combining individual and geographically aggregated datasets using the recent R packages ipfp and mipfp. This approach represents the "best of both worlds" in terms of spatial resolution and person-level detail, overcoming issues of data confidentiality and reproducibility. Implement the Methods on Your Own Data Full of reproducible examples using code and data, the book is suitable for students and applied researchers in health, economics, transport, geography, and other fields that require individual-level data allocated to small geographic zones. By explaining how to use tools for modeling phenomena that vary over space, the book enhances your knowledge of complex systems and empowers you to provide evidence-based policy guidance.

Download or read book Handbook of Educational Measurement and Psychometrics Using R written by Christopher D. Desjardins and published by CRC Press. This book was released on 2018-09-03 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently there are many introductory textbooks on educational measurement and psychometrics as well as R. However, there is no single book that covers important topics in measurement and psychometrics as well as their applications in R. The Handbook of Educational Measurement and Psychometrics Using R covers a variety of topics, including classical test theory; generalizability theory; the factor analytic approach in measurement; unidimensional, multidimensional, and explanatory item response modeling; test equating; visualizing measurement models; measurement invariance; and differential item functioning. This handbook is intended for undergraduate and graduate students, researchers, and practitioners as a complementary book to a theory-based introductory or advanced textbook in measurement. Practitioners and researchers who are familiar with the measurement models but need to refresh their memory and learn how to apply the measurement models in R, would find this handbook quite fulfilling. Students taking a course on measurement and psychometrics will find this handbook helpful in applying the methods they are learning in class. In addition, instructors teaching educational measurement and psychometrics will find our handbook as a useful supplement for their course.

Download or read book Reproducible Finance with R written by Jonathan K. Regenstein, Jr. and published by CRC Press. This book was released on 2018-09-24 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproducible Finance with R: Code Flows and Shiny Apps for Portfolio Analysis is a unique introduction to data science for investment management that explores the three major R/finance coding paradigms, emphasizes data visualization, and explains how to build a cohesive suite of functioning Shiny applications. The full source code, asset price data and live Shiny applications are available at reproduciblefinance.com. The ideal reader works in finance or wants to work in finance and has a desire to learn R code and Shiny through simple, yet practical real-world examples. The book begins with the first step in data science: importing and wrangling data, which in the investment context means importing asset prices, converting to returns, and constructing a portfolio. The next section covers risk and tackles descriptive statistics such as standard deviation, skewness, kurtosis, and their rolling histories. The third section focuses on portfolio theory, analyzing the Sharpe Ratio, CAPM, and Fama French models. The book concludes with applications for finding individual asset contribution to risk and for running Monte Carlo simulations. For each of these tasks, the three major coding paradigms are explored and the work is wrapped into interactive Shiny dashboards.

Download or read book Statistical Models in Toxicology written by Mehdi Razzaghi and published by CRC Press. This book was released on 2020-05-21 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Models in Toxicology presents an up-to-date and comprehensive account of mathematical statistics problems that occur in toxicology. This is as an exciting time in toxicology because of the attention given by statisticians to the problem of estimating the human health risk for environmental and occupational exposures. The development of modern statistical techniques with solid mathematical foundations in the 20th century and the advent of modern computers in the latter part of the century gave way to development of many statistical models and methods to describe toxicological processes and attempts to solve the associated problems. Not only have the models enjoyed a high level of elegance and sophistication mathematically, they are widely used by industry and government regulatory agencies. Features: Focuses on describing the statistical models in environmental toxicology that facilitate the assessment of risk mainly in humans. The properties and shortfalls of each model are discussed and its impact in the process of risk assessment is examined. Discusses models that assess the risk of mixtures of chemicals. Presents statistical models that are developed for risk estimation in different aspects of environmental toxicology including cancer and carcinogenic substances. Includes models for developmental and reproductive toxicity risk assessment, risk assessment in continuous outcomes and developmental neurotoxicity. Contains numerous examples and exercises. Statistical Models in Toxicology introduces a wide variety of statistical models that are currently utilized for dose-response modeling and risk analysis. These models are often developed based on design and regulatory guidelines of toxicological experiments. The book is suitable for practitioners or as use as a textbook for advanced undergraduate or graduate students of mathematics and statistics.

Download or read book R Primer written by Claus Thorn Ekstrom and published by CRC Press. This book was released on 2017-07-28 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Newcomers to R are often intimidated by the command-line interface, the vast number of functions and packages, or the processes of importing data and performing a simple statistical analysis. The R Primer provides a collection of concise examples and solutions to R problems frequently encountered by new users of this statistical software. This new edition adds coverage of R Studio and reproducible research.

Download or read book Information Resources in Toxicology Volume 1 Background Resources and Tools written by and published by Academic Press. This book was released on 2020-05-16 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources - Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles - Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals - Explores recent internet trends, web-based databases, and software tools in a section on the online environment - Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents - Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field

Download or read book Testing R Code written by Richard Cotton and published by CRC Press. This book was released on 2017-01-12 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn how to write R code with fewer bugs. The problem with programming is that you are always one typo away from writing something silly. Likewise with data analysis, a small mistake in your model can lead to a big mistake in your results. Combining the two disciplines means that it is all too easy for a missed minus sign to generate a false prediction that you don’t spot until it’s too late. Testing is the only way to be sure that your code, and your results, are correct. Testing R Code teaches you how to perform development-time testing using the testthat package, allowing you to ensure that your code works as intended. The book also teaches run-time testing using the assertive package; enabling your users to correctly run your code. After beginning with an introduction to testing in R, the book explores more advanced cases such as integrating tests into R packages; testing code that accesses databases; testing C++ code with Rcpp; and testing graphics. Each topic is explained with real-world examples, and has accompanying exercises for readers to practise their skills — only a small amount of experience with R is needed to get started!

Download or read book Flexible Regression and Smoothing written by Mikis D. Stasinopoulos and published by CRC Press. This book was released on 2017-04-21 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about learning from data using the Generalized Additive Models for Location, Scale and Shape (GAMLSS). GAMLSS extends the Generalized Linear Models (GLMs) and Generalized Additive Models (GAMs) to accommodate large complex datasets, which are increasingly prevalent. In particular, the GAMLSS statistical framework enables flexible regression and smoothing models to be fitted to the data. The GAMLSS model assumes that the response variable has any parametric (continuous, discrete or mixed) distribution which might be heavy- or light-tailed, and positively or negatively skewed. In addition, all the parameters of the distribution (location, scale, shape) can be modelled as linear or smooth functions of explanatory variables. Key Features: Provides a broad overview of flexible regression and smoothing techniques to learn from data whilst also focusing on the practical application of methodology using GAMLSS software in R. Includes a comprehensive collection of real data examples, which reflect the range of problems addressed by GAMLSS models and provide a practical illustration of the process of using flexible GAMLSS models for statistical learning. R code integrated into the text for ease of understanding and replication. Supplemented by a website with code, data and extra materials. This book aims to help readers understand how to learn from data encountered in many fields. It will be useful for practitioners and researchers who wish to understand and use the GAMLSS models to learn from data and also for students who wish to learn GAMLSS through practical examples.

Download or read book bookdown written by Yihui Xie and published by CRC Press. This book was released on 2016-12-12 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: bookdown: Authoring Books and Technical Documents with R Markdown presents a much easier way to write books and technical publications than traditional tools such as LaTeX and Word. The bookdown package inherits the simplicity of syntax and flexibility for data analysis from R Markdown, and extends R Markdown for technical writing, so that you can make better use of document elements such as figures, tables, equations, theorems, citations, and references. Similar to LaTeX, you can number and cross-reference these elements with bookdown. Your document can even include live examples so readers can interact with them while reading the book. The book can be rendered to multiple output formats, including LaTeX/PDF, HTML, EPUB, and Word, thus making it easy to put your documents online. The style and theme of these output formats can be customized. We used books and R primarily for examples in this book, but bookdown is not only for books or R. Most features introduced in this book also apply to other types of publications: journal papers, reports, dissertations, course handouts, study notes, and even novels. You do not have to use R, either. Other choices of computing languages include Python, C, C++, SQL, Bash, Stan, JavaScript, and so on, although R is best supported. You can also leave out computing, for example, to write a fiction. This book itself is an example of publishing with bookdown and R Markdown, and its source is fully available on GitHub.

Download or read book Practical R for Mass Communication and Journalism written by Sharon Machlis and published by CRC Press. This book was released on 2018-12-21 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do you want to use R to tell stories? This book was written for you—whether you already know some R or have never coded before. Most R texts focus only on programming or statistical theory. Practical R for Mass Communication and Journalism gives you ideas, tools, and techniques for incorporating data and visualizations into your narratives. You’ll see step by step how to: Analyze airport flight delays, restaurant inspections, and election results Map bank locations, median incomes, and new voting districts Compare campaign contributions to final election results Extract data from PDFs Whip messy data into shape for analysis Scrape data from a website Create graphics ranging from simple, static charts to interactive visualizations for the Web If you work or plan to work in a newsroom, government office, non-profit policy organization, or PR office, Practical R for Mass Communication and Journalism will help you use R in your world. This book has a companion website with code, links to additional resources, and searchable tables by function and task. Sharon Machlis is the author of Computerworld’s Beginner’s Guide to R, host of InfoWorld’s Do More With R video screencast series, admin for the R for Journalists Google Group, and is well known among Twitter users who follow the #rstats hashtag. She is Director of Editorial Data and Analytics at IDG Communications (parent company of Computerworld, InfoWorld, PC World and Macworld, among others) and a frequent speaker at data journalism and R conferences.