Download or read book Spontaneous and Virus Induced Transformation in Cell Culture written by Jan Ponten and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: A. Definitions of Transformation in vitro When normal tissues or organs are explanted to conditions favoring the growth of cells as individual units ("cell culture"), the original cell population undergoes a large variety of modifications. Only a minority of the cells will thrive and multiply and within a rather short period of time, the complex composition of the original explant is replaced by a much simplified one of only a few recogniz ably different cell types. With most organs fibroblast-like cells survive longest and outgrow other types. This is then a stable state of affairs for many gener ations. This treatise will not discuss whether this simplification and stabilization represents selection of certain pre-existing cell types or a modification of cells into only a few recognizably different categories; for an excellent review see HARRIS. (1964). Table 1. Terminology Employed to Describe Transformations in vitro Type of transformation Essential features Irregular growth Lack of contact inhibition of cell membrane movement ("ruffled membranes") between juxtaposed cells Unrestrained growth Deficient inhibition of the cell cycle (mitosis) in a crowded culture Infinite growth Capacity of cells to undergo an infinite number of di visions (formation of established cell lines) Cells may depart from this typical behavior in numerous ways involving for instance cellular morphology, immunology, chromosomes or metabolism. Such changes have, sometimes rather vaguely, been called "transformations". This is unprecise and the term "transformation" will here be used exclusively to indicate disturbances in cell growth related to neoplasia.

Download or read book Spontaneous and Virus Induced Transformation in Cell Culture written by Jan Pontén and published by Springer. This book was released on 1971 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: When normal tissues or organs are explanted to conditions favoring the growth of cells as individual units (cell culture) the original cell population undergoes a large variety of modification. Only a minory of the cells with thrive and multiply and within a rather short period of time, the complex composition of the original explant is replaced by a much simplified one and only a few recognizably different cell types.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1985 with total page 1160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1980 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Carcinogenesis Abstracts written by and published by . This book was released on 1977 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Partial Bibliography on Type B and Type C Viruses in Relation to Animal Neoplasia Covering Period of Jan 1967 through Dec 1970 written by National Cancer Institute (U.S.) and published by . This book was released on 1971 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book International Review of Cytology written by and published by Academic Press. This book was released on 1965-01-01 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology

Download or read book Partial Bibliography on Type B and Type C Viruses in Relation to Animal Neoplasia Covering Period of January 1967 through December 1970 written by National Cancer Institute (U.S.). Program Analysis and Communication Section. Information Unit and published by . This book was released on 1971 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Epstein Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Download or read book Subject Index of Current Extramural Research Administered by the National Cancer Institute written by National Cancer Institute (U.S.) and published by . This book was released on 1974 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Subject Index of Current Extramural Research Administered by the National Cancer Institute written by and published by . This book was released on 1978 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Research Awards Index written by and published by . This book was released on 1980 with total page 1230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Published Scientific Papers of the National Institutes of Health written by National Institutes of Health (U.S.) and published by . This book was released on 1974 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue lists papers published during the preceding year.

Download or read book Scientific Directory and Annual Bibliography written by National Institutes of Health (U.S.) and published by . This book was released on 1973 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.