Download or read book Spectroscopic and Theoretical Studies of Complexes which Model the Active Sites of Non heme Iron Proteins written by Carl A. Brown and published by . This book was released on 1994 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectroscopic Studies of the Non heme Iron Active Sites of Lipoxygenases and S written by Mark A. Pavlosky and published by . This book was released on 1994 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectroscopic and Theoretical Elucidation of Structural Contributions to Reactivity in Binuclear Non heme Iron Enzymes written by Jennifer Kathleen Schwartz and published by . This book was released on 2008 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectroscopic Characterization of Binuclear Non heme Iron and MN FE Active Sites written by Yeonju Kwak and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Binuclear non-heme iron enzymes catalyze various reactions including H-atom abstraction, desaturation, hydroxylation, and electrophilic aromatic substitution through O2 activation. In addition, they protect cells from oxidative stress and regulate iron levels in the cell. These enzymes utilize two irons and have common structural motif of 2-His / 4-carboxylate. Despite the enzymes' structural similarities, subtle changes at their active sites allow these enzymes to have different reactivities. Understanding the active site structures of these enzymes and the key mechanistic features related to these structures can provide a basis for potential applications: they could be drug inhibition targets to treat cancer, diabetes, and pathogenic diseases; they could work as biocatalysts; and they could carry out bioremediation reactions. In this dissertation, studies that examine three binuclear non-heme iron and Mn/Fe enzyme active sites (class Ic ribonucleotide reductase, ferritin variants, and bacterioferritin) and peroxo-bridged biferric model complexes are described. A combined spectroscopic methodology of nuclear resonance vibrational spectroscopy (NRVS), circular dichroism (CD), magnetic circular dichroism (MCD), and variable temperature, variable field (VTVH) MCD is used to probe geometric and electronic structures of Mn and Fe centers in protein active site and in model complexes.
Download or read book Spectroscopic and Theoretical Investigations of Iron Active Sites Electronic Structure Contributions to Electron Transfer Reactivity written by Pierre Kennepohl and published by . This book was released on 2002 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectroscopic and Theoretical Studies of Mononuclear Non heme Iron Enzymes written by Adrienne Renee Diebold and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Mononuclear non-heme iron enzymes are an important class with a wide range of medical, pharmaceutical and environmental applications. Within this class, the oxygen activating enzymes use Fe(II) to activate O2 for reaction with the substrate. The focus of this thesis is on understanding two major themes of the oxygen activating enzymes - the role of the (2His/1 carboxylate) facial triad and the initial O2 reaction steps of alpha-keto acid-dependent dioxygenases - using a combination of spectroscopic techniques and DFT calculations. For ferrous systems, abs/CD/MCD/VTVH MCD studies define the geometric and electronic structure of the ferrous site. In combination with DFT calculations, a structure/function picture of the ferrous sites is developed. To extend these studies to the initial steps of O2 binding, studies with NO as an O2 analogue ({FeNO}7/{FeO2}8) utilize EPR/abs/CD/MCD/VTVH MCD spectroscopy with DFT calculations to elucidate important effects of the substrate on the {FeNO}7 bond. These effects are used in the computational extension to the experimentally inaccessible O2 bound complexes giving insight into the initial steps of O2 binding and activation. Taken together, these studies shed light on the rational for facial triad ligation at the Fe(II) site in the oxygen activating enzymes and how the Fe(II) ligand set tunes the specific reactivity of these enzymes.
Download or read book Nitrosyl Complexes in Inorganic Chemistry Biochemistry and Medicine I written by D. Michael P. Mingos and published by Springer. This book was released on 2014-06-05 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors. Readership: research scientists at universities or in industry, graduate students Special offer For all customers who have a standing order to the print version of Structure and Bonding, we offer free access to the electronic volumes of the Series published in the current year via SpringerLink.
Download or read book X ray Absorption Spectroscopic Studies of Non heme Iron Proteins and Model Complexes written by Ekaterina Y. Shishova and published by . This book was released on 2003 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1987 with total page 1398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Magnetic Circular Dichroism Spectroscopic Studies of Mononuclear Non heme Iron Sites written by Elizabeth Gottlieb Pavel and published by . This book was released on 1997 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book X ray Absorption Spectroscopic and Theoretical Studies on Copper Containing Proteins written by Ritimukta Sarangi and published by . This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectroscopic and DFT Studies of Thiol and Olefin Coordinated Non heme Iron Dinitrosyl Complexes written by Miguel Angel Camacho Fernandez and published by . This book was released on 2010 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Recent developments involving the physiological implications of nitric oxide have spurred an intense interest in transition metal nitrosyl complexes, especially those that mimic the structures of biologically active metal nitrosyl complexes. In order to get insights on the electronic configuration, molecular orbital's interaction, and explain spectroscopic (NMR, EPR, and IR) observations, Density Functional Theory calculations were carried out on three series of metal nitrosyl complexes, Fe(NO)2 (P(OCH3)3)[eta]2-TCNE, [Fe2([mu]-RS)2(NO)4], and [Fe(NO)2(Im-H)]4 . The unusually high rotation barrier observed by NMR was explained through fragment analysis of Fe(NO)2 and TCNE. In addition, the difference of the g values between the reduced form of Roussin's red Esters and the typical dinitrosyl iron complexes is explained, for the first time, by of the difference in unpaired electron distributions between the two types of complexes, which provides the theoretical basis for the use of g value as a spectroscopic tool to differentiate these biologically active complexes.
Download or read book Spectroscopic Studies of Mixed valent Binuclear Non heme Iron Active Sites written by James Malcolm McCormick and published by . This book was released on 1991 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physical Characterization of Diiron dioxygen Complexes and Resonance Raman Studies of Mononuclear Non heme Iron Proteins written by Bridget Anne Brennan and published by . This book was released on 1991 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iron oxo Complexes written by Cheryl A. Christmas and published by . This book was released on 1993 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
