Download or read book Use of Laboratory Animals in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
Download or read book Science Medicine and Animals written by National Research Council and published by National Academies Press. This book was released on 2006-02-19 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.
Download or read book Recognition and Alleviation of Distress in Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2008-04-10 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.
Download or read book Anthrax in Humans and Animals written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the anthrax guidelines encompasses a systematic review of the extensive new scientific literature and relevant publications up to end 2007 including all the new information that emerged in the 3-4 years after the anthrax letter events. This updated edition provides information on the disease and its importance, its etiology and ecology, and offers guidance on the detection, diagnostic, epidemiology, disinfection and decontamination, treatment and prophylaxis procedures, as well as control and surveillance processes for anthrax in humans and animals. With two rounds of a rigorous peer-review process, it is a relevant source of information for the management of anthrax in humans and animals.
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Download or read book Plants for Toxicity Assessment written by Wun-cheng Wang and published by ASTM International. This book was released on 1991 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The First Symposium on Use of Plants for Toxicity Assessment was held in Atlanta, Georgia, on April 19-20, 1989. This publication contains 29 refereed papers divided into six groups: Regulatory Perspectives, Comparative Toxicology, Plants and Xenobiotic Uptake, Plants and Air Pollution, General Phytotoxicology, and New Approaches. The 2nd Symposium on Use of Plants for Toxicity Assessment was held in San Francisco, California, on April 23-24, 1990. This publication contains 35 refereed papers divided into six groups: Regulatory Perspectives, Applications of Plant Bioassays/Photosynthesis, Xenobiotic Uptake by Plants, General Phytotoxicology, Biochemical and Genetic Applications, and New Approaches.
Download or read book Overview of the ecological risk assessment process in the Office of Pesticide Programs U S Environmental Protection Agency endangered and threatened species effects determinations written by United States. Environmental Protection Agency. Office of Pesticide Programs and published by DIANE Publishing. This book was released on 2004 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book OECD Series on Testing and Assessment Fish Toxicity Testing Framework written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-12-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Download or read book Nonclinical Safety Assessment written by William J. Brock and published by John Wiley & Sons. This book was released on 2013-04-29 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonclinical Safety Assessment Nonclinical Safety Assessment A Guide to International Pharmaceutical Regulations Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions. It includes: ICH – the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use National regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and Australia Repeated dose toxicity studies Carcinogenicity; Genotoxicity; Developmental and reproductive toxicology; Immunotoxicology Biotechnology-derived pharmaceuticals Vaccine development Phototoxicity and photocarcinogenicity Degradants, impurities, excipients and metabolites Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.
Download or read book Environmental Flow Assessment written by John G. Williams and published by John Wiley & Sons. This book was released on 2019-06-10 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides critiques of current practices for environmental flow assessment and shows how they can be improved, using case studies. In Environmental Flow Assessment: Methods and Applications, four leading experts critique methods used to manage flows in regulated streams and rivers to balance environmental (instream) and out-of-stream uses of water. Intended for managers as well as practitioners, the book dissects the shortcomings of commonly used approaches, and offers practical advice for selecting and implementing better ones. The authors argue that methods for environmental flow assessment (EFA) can be defensible as well as practicable only if they squarely address uncertainty, and provide guidance for doing so. Introductory chapters describe the scientific and social reasons that EFA is hard, and provide a brief history. Because management of regulated streams starts with understanding freshwater ecosystems, Environmental Flow Assessment: Methods and Applications includes chapters on flow and organisms in streams. The following chapters assess standard and emerging methods, how they should be tested, and how they should (or should not) be applied. The book concludes with practical recommendations for implementing environmental flow assessment. Describes historical and recent trends in environmental flow assessment Directly addresses practical difficulties with applying a scientifically informed approach in contentious circumstances Serves as an effective introduction to the relevant literature, with many references to articles in related scientific fields Pays close attention to statistical issues such as sampling, estimation of statistical uncertainty, and model selection Includes recommendations for methods and approaches Examines how methods have been tested in the past and shows how they should be tested today and in the future Environmental Flow Assessment: Methods and Applications is an excellent book for biologists and specialists in allied fields such as engineering, ecology, fluvial geomorphology, environmental planning, landscape architecture, along with river managers and decision makers.
Download or read book Handbook of Alien Species in Europe written by Delivering Alien Invasive Species and published by Springer Science & Business Media. This book was released on 2008-11-14 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological invasions by alien (non-native) species are widely recognized as a significant component of human-caused global environmental change and the second most important cause of biodiversity decline. Alien species threaten many European ecosystems and have serious environmental, economic and health impacts. The DAISIE (Delivering Alien Invasive Species Inventories for Europe) project has now brought together all available information on alien species in Europe (terrestrial, aquatic and marine) and from all taxa (fungi, plants, animals). Thus for the first time, an overview and assessment of biological invasions in the Pan-European region is finally possible. The Handbook of Alien Species in Europe summarises the major findings of this groundbreaking research and addresses the invasion trends, pathways, and both economic as well as ecological impact for eight major taxonomic groups. Approximately 11.000 alien species recorded in Europe are listed, and fact sheets for 100 of the most invasive alien species are included, each with a distribution map and colour illustration. The book is complemented by a regularly updated internet database providing free additional information. With its highly interdisciplinary approach, DAISIE and its Handbook will be the basis for future scientific investigations as well as management and control of alien invasive species in Europe.
Download or read book OECD Series on Testing and Assessment Detailed Review Paper DRP on Molluscs Life cycle Toxicity Testing written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to EDCs and to other chemicals.
Download or read book Bioindicators Biomonitors written by Bernd A. Markert and published by Elsevier. This book was released on 2003-06-30 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of contents
Download or read book Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity written by National Research Council and published by National Academies Press. This book was released on 2001-04-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).
Download or read book Animals as Sentinels of Environmental Health Hazards written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying animals in the environment may be a realistic and highly beneficial approach to identifying unknown chemical contaminants before they cause human harm. Animals as Sentinels of Environmental Health Hazards presents an overview of animal-monitoring programs, including detailed case studies of how animal health problemsâ€"such as the effects of DDT on wild bird populationsâ€"have led researchers to the sources of human health hazards. The authors examine the components and characteristics required for an effective animal-monitoring program, and they evaluate numerous existing programs, including in situ research, where an animal is placed in a natural setting for monitoring purposes.
