Download or read book Spatially dense Multi spectral Frequency domain Diffuse Optical Tomography of Breast Cancer written by Han Yong Ban and published by . This book was released on 2015 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) employs near-infrared light to image the concentration of chromophores and cell organelles in tissue and thereby providing access to functional parameters that can differentiate cancerous from normal tissues. This thesis describes research at the bench and in the clinic that explores and identifies the potential of DOT breast cancer imaging. The bench and clinic instrumentation differ but share important features: they utilize a very large, spatially dense, set of source-detector pairs (10 7) for imaging in the parallel-plate geometry.
Download or read book Multi spectral and Fluorescence Diffuse Optical Tomography of Breast Cancer written by Alper Corlu and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Portable Broadband Multi channel Instrument for Frequency domain Diffuse Optical Spectroscopy and Imaging written by Nick Haghany and published by . This book was released on 2013 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical spectroscopic imaging (DOSI) is a non-invasive technique based on multiply-scattered near-infrared (NIR) light for quantitative imaging and characterization of thick tissues. The DOSI system combines frequency-domain (FD) photon migration with time-independent reflectance spectroscopy to measure broadband NIR absorption and reduced scattering spectra. The goal of this research is to develop a portable multi-channel DOSI instrument that employs a handheld probe capable of acquiring broadband absorption and scattering spectra from four unique spatial views. Each view is defined by source-detector (SD) pairs separated by 15, 20, 28 and 35mm in reflectance geometry. Absorption and scattering spectra (650-1000 nm) are obtained by combining 50-500MHz multi-frequency, frequency domain photon migration (FDPM) at four NIR wavelengths (660, 690, 785 and 830) with time-independent broadband spectroscopy. The key feature of the multi-channel DOSI instrument is a custom designed board which provides a more compact design that made it possible to integrate multiple FD boards and build a scalable multi-channel system for the first time. Preliminary results from measurements of tissue-simulating phantoms and breast cancer patients revealed significant differences in tumor versus normal tissue optical properties for each view in 2D maps. In a patient treated with neoadjuvant chemotherapy, the shorter channels (SD 15, 20 and 28mm) showed significant change in contrast between the tumor and normal tissue optical properties during the course of neoadjuvant treatment; however this contrast for the longest channel (SD 35mm) stayed almost constant throughout the treatment. This suggest that our four channel design is capable of mapping spatially varying subsurface tissue metabolism such as tumors, as well as monitoring response to the neoadjuvant chemotherapy. Preliminary work on tomographic reconstruction of broadband optical properties from the multiple view data showed promising results; however more work needs to be done to accomplish the subsurface reconstruction from the multi-view data.
Download or read book Breast Density Quantification Using Structured light Diffuse Optical Tomography written by Jessica Ruiz and published by . This book was released on 2016 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anatomical breast density is an independent risk factor for breast cancer, where women with larger amounts of dense fibroglandular tissue (FGT) are more likely to develop breast cancer. Clinical models that consider personal information about a woman (age, family history, and genetics) to predict her risk for breast cancer can help her customize their own screening options or consider preventative measures. Although magnetic resonance imaging (MRI) can be used to quantitatively measure the FGT volume, its high-cost makes it impractical to implement. Optical methods provide an appealing alternative, where the systems are low-cost and easily compactable, which makes clinical implementation easier. Optical tomography can spatially resolve and measure the concentration of relevant chromophores within the breast: water, lipid, oxy and deoxyhemoglobin. We have investigated the use of structured-light diffuse optical tomography (SL-DOT) in imaging the breast volume. In SL-DOT, spatially modulated light is illuminated and collected from the breast through the use of two digital micro-mirror devices (DMDs). Through both simulations and phantom studies, we found that SL-DOT is suitable for predicting the percentage of FGT when taking into consideration both the volume segmented from the chromophore maps and the recovered chromophore concentrations. A second independent risk factor in which we are interested is the functional breast density . After intravenous injection of a MRI contrast agent, the intensity of the FGT is enhanced to varying degrees among patients, referred to as background parenchymal enhancement (BPE). It has been shown that BPE is also correlated with breast cancer incidence, most likely due to the higher perfusion of nutrients in blood to the FGT. Because BPE is an indication of blood flow, we believe the hemoglobin content measured from SL-DOT will be correlated to the BPE seen in MRI; therefore, our technique can potentially measure two independent risk factors for breast cancer. Once clinically translated, SL-DOT can be used to measure both the anatomical and functional breast density inexpensively and quickly, allowing women to make informed decisions about their breast cancer screening.
Download or read book Advances in Optical Imaging for Clinical Medicine written by Nicusor Iftimia and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.
Download or read book A Multimodal Breast Cancer Imaging System Using Coregistered Dynamic Diffuse Optical Tomography and Digital Breast Tomosynthesis written by Bernhard B. Zimmermann and published by . This book was released on 2017 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) is an emerging noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (1 Hz+) image acquisition rate to enable tracking of hemodynamic changes induced by the mammographic breast compression. The most significant advance enabling fast acquisition was the design and construction of a direct analog-to-digital conversion frequency-domain near-infrared spectroscopy (FD-NIRS) component. It achieves simultaneous dual wavelength operation at 685 nm and 830 nm by concurrent 67.5 MHz and 75 MHz frequency modulation of each laser source, respectively, followed by digitization using a high-speed analog to digital converter and real-time hybrid FPGA-assisted demodulation by discrete Fourier transform (DFT). The overall DOT system integrates 96 CW-NIRS and 24 FD-NIRS source locations, as well as 32 CW-NIRS and 20 FD-NIRS detection locations into low-profile plates that mate to the DBT compression paddle and x-ray detector cover, respectively. The plates and the embedded optical fibers are made of plastic to minimize x-ray absorption and thus allow true simultaneous acquisition of the DBT image. We first characterize each major system component individually, and then demonstrate overall performance using static and dynamic tissue-like phantoms, as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.
Download or read book Concurrent Diffuse Optical Tomography Spectroscopy and Magnetic Resonance Imaging of Breast Cancer written by Vasilis Ntziachristos and published by . This book was released on 2000 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Biomedical Optics written by David A. Boas and published by CRC Press. This book was released on 2016-04-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Download or read book Advanced Biophotonics written by Ruikang K. Wang and published by Taylor & Francis. This book was released on 2016-04-19 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics: Tissue Optical Sectioning presents contemporary methods and
Download or read book Parallel rapid diffuse optical tomography of breast written by and published by . This book was released on 2002 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last year we have experimentally and computationally investigated rapid acquisition and analysis of informationally dense diffuse optical data sets in the parallel plate compressed breast geometry. We have developed and tested a 3-dimensional image reconstruction algorithm for the diffusive wave inverse problem that runs on a parallel computer cluster. This code uses a finite difference method in the forward calculation, a novel Integro-Differential equation, previously developed by this group, in the reconstruction. There has been a significant improvement in our instrumentation and measurement capabilities. A hybrid RF/CW diffuse optical tomography (DOT) system measures limited number of frequency-domain reemission data and significantly larger continuous wave transmission data by a lens coupled CCD simultaneously. The wavelength of the light source is optically switched from 690, 750, 786 and 830 nm and then its position is switched among 45 different positions on the compression plate. The instrument and reconstruction algorithm performance have been tested using small silicone tissue phantoms as a tumor of various size and optical properties suspended into the liquid tissue phantom. The study of the effect of boundary between the matching fluid and breast has been initiated by building and taking measurements from tissue phantoms with breast shape, embedded with small objects with higher absorption or scattering.
Download or read book Imaging and Metabolism written by Jason S. Lewis and published by Springer. This book was released on 2017-09-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.
Download or read book Correlations Among Ultrasound Guided Diffuse Optical Tomography Microvessel Density and Breast Cancer Prognosis written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomedical Optical Imaging written by James G. Fujimoto and published by Oxford University Press. This book was released on 2009-04-22 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
Download or read book Molecular Imaging written by Ralph Weissleder and published by PMPH-USA. This book was released on 2010 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.
Download or read book Biomedical Photonics Handbook written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2003-03-26 with total page 1864 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide variety of biomedical photonic technologies have been developed recently for clinical monitoring of early disease states; molecular diagnostics and imaging of physiological parameters; molecular and genetic biomarkers; and detection of the presence of pathological organisms or biochemical species of clinical importance. However, available in
Download or read book Methods for Improving the Reconstruction of Diffuse Optical Tomography for Breast Cancer Detection written by Murad Mohsen Althobaiti and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Breast Cancer Using an Endogenous Tumor Spectral Marker written by Shanshan Xu and published by . This book was released on 2012 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging has enjoyed a large following in cancer in general and breast cancer in particular (i.e., diffuse optical imaging, DOI and diffuse optical tomography, DOT). Optical imaging biomarkers emerge from modeling specific near-infrared (NIR) absorption signatures that are sensitive indicators of important molecular concentration and disposition. We have developed Diffuse Optical Spectroscopic Imaging (DOSI) by increasing spectral information content for the purpose of increasing access to molecular targets and states. Malignancy-specific optical imaging biomarkers may be important because the above-mentioned changes in tumor hemoglobin, water and lipids are a necessary but not a sufficient condition to classify therapeutic response. We note that for all therapeutic imaging assessments (i.e., mammography, ultrasound, MRI, PET) that the same case is true for their respective contrast mechanisms. By a novel spectral analysis method, we have discovered the presence of absorption signatures that are unique to malignant lesions. A reproducible absorption spectrum (Specific Tumor Component, STC) with several distinct spectral features emerges when compared with the normal absorption spectra (the flat line near zero) measured from the normal tissue of these subjects plus an additional 21 patients without any evidence of malignancy. These data demonstrate the existence of a spectral signature that acts as an optical biomarker for malignancy. We are not aware of any other such biomarker that combines high specificity with ease of application in the imaging field. This DOSI-measured malignancy-specific biomarker STC provides an ideal non-invasive surrogate biomarker for breast lesion detection and differentiation. Although STC offers both spectroscopic and quantitative information for breast malignancy, this method relies on complicated data analysis and lacks of standardization. Thus, it is still far from a clinical reality. In order to carry out a quantitative assessment of its potential in becoming a standardized clinical detection modality for tumor detection/prediction/prognosis, the longitudinal temporal stability of signatures must be evaluated and the detection limit must be set. The overall clinical goal is to evaluate the possibilities for STC detection method to become a future clinical practice. Building the linkage between pre-existing detection modalities (pathological biomarkers, DCE-MRI) and novel spectral signature detection is essential. The medical interpretation of the findings from conventional tools will shed light on the understanding and further employment of STC biomarker. Similarly, STC detection with a high diagnosis sensitivity and specificity could be very well an adjunct method for traditional modalities.
