Download or read book Sp1 is Necessary for Maximal Transcription of the Eukaryotic Translation Initiation Factor 4b EIF4B Gene written by Dulce M. Alvarado and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic translation initiation factor 4b (EIF4B) is a gene that encodes an RNA binding protein involved in the initiation step of protein synthesis. Phosphorylation and high protein levels of EIF4B have been associated with the development of tumorigenesis. Because EIF4B gene expression is essential for translation, the EIF4B putative promoter region was identified and characterized. [...]
Download or read book Physical Activity Fitness and Health written by Claude Bouchard and published by Champaign, IL : Human Kinetics Publishers. This book was released on 1994 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can health-care costs be reduced by increasing the overall level of physical activity? What part does heredity play in physical fitness? How does exercise affect the immune system? What is the relationship between physical activity and hypertension?
Download or read book Progressive Brain Disorders in Childhood written by Juan M. Pascual and published by Cambridge University Press. This book was released on 2017-04-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.
Download or read book Progress in the Chemistry of Organic Natural Products 108 written by A. Douglas Kinghorn and published by Springer. This book was released on 2019-03-28 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. The second contribution provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses. And the third contribution discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.
Download or read book Epigenetic Regulation and Epigenomics written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2012-10-02 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Understanding Viruses written by Teri Shors and published by Jones & Bartlett Publishers. This book was released on 2017 with total page 969 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Viruses continues to set the standard for the fundamentals of virology. This classic textbook combines molecular, clinical, and historical aspects of human viral diseases in a new stunning interior design featuring high quality art that will engage readers. Preparing students for their careers, the Third Edition greatly expands on molecular virology and virus families. This practical text also includes the latest information on influenza, global epidemiology statistics, and the recent outbreaks of Zika and Ebola viruses to keep students on the forefront of cutting-edge virology information. Numerous case studies and feature boxes illuminate fascinating research and historical cases stimulate student interest, making the best-selling Understanding Viruses the clear choice in virology. Each new print copy includes Navigate 2 Advantage Access that unlocks a comprehensive and interactive eBook, student practice activities and assessments, a full suite of instructor resources (available to adopting instructors with course ID), and learning analytics reporting tools (available to adopting instructors with course ID).
Download or read book Translation Initiation Reconstituted Systems and Biophysical Methods written by and published by Academic Press. This book was released on 2007-10-23 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.
Download or read book Histone Modifications in Therapy written by Pedro Castelo-Branco and published by Academic Press. This book was released on 2020-09-04 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists
Download or read book Behavioral Neurogenetics written by John F. Cryan and published by Springer Science & Business Media. This book was released on 2012-05-04 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
Download or read book Urologic Surgical Pathology E Book written by Liang Cheng and published by Elsevier Health Sciences. This book was released on 2008-06-25 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised with practical guidance in daily urological pathology sign-out and the latest recommended diagnostic approaches, the new edition of this comprehensive reference equips you to accurately diagnose specimens of the entire urinary tract and male reproductive system plus the adrenal glands. It begins with a look at normal anatomy and histology for each organ system...followed by discussions of the pathology of congenital anomalies, inflammations, non-neoplastic diseases and neoplasia. An emphasis on clinicopathologic and radiographic-pathologic correlations makes this a true diagnostic decision-making guide. A consistent format enables you to locate critical information quickly, and morethan 1500 high-quality illustrations — most in full color — make diagnosis even easier. Presents the practice-proven experience of today’s authorities to enable you to diagnose with confidence. Limits coverage of general mechanisms of disease and anatomy to the most relevant information needed to fully comprehend the clinical picture. Includes boxed lists of types and causes of diseases, differential diagnosis, characteristic features of diseases, complications, classifications, and staging that help you quickly locate the specific information you need. Presents two brand-new chapters covering urinary cytology and fine needle aspiration to keep you up to date. Covers newly described entities and application of ancillary study for precise diagnosis. Features integration of new molecular techniques and immunohistochemical analysis for differential diagnosis. Equips you with the latest recommended diagnostic approaches help you make the most informed decisions. Provides you with a critical review of the current classifications of cancer and disease. Features more than 1500 high-quality illustrations-in full color—providing a complete visual perspective of the conditions encountered in pathology.
Download or read book Sensing Signaling and Cell Adaptation written by J.M. Storey and published by Elsevier. This book was released on 2002-09-16 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume of Cell and Molecular Responses to Stress articles provide up-to-date information on key areas of signal sensing (sensing of pain, heat, cold, light, infrared radiation), molecules involved in the intracellular transmission of these signals, metabolic responses to stress including changes in gene expression and production of specialized proteins that aid cell responses to factors including interrupted blood supply (ischemia), oxygen limitation (hypoxia/anoxia), freezing and dehydration, amino acid limitation, radiation and processing drugs. There are chapters which also provide insights into new technologies (such as cDNA arrays), analysis of metabolic control theory (a key method for analysing stress effects on cells), and examine how enzymes evolve in the face of stress.
Download or read book Kidney Transplant Rejection written by G. Melville Williams and published by . This book was released on 1986 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prenatal Diagnosis of Congenital Anomalies written by Roberto Romero and published by McGraw-Hill/Appleton & Lange. This book was released on 1988 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Environmental Science of Drinking Water written by Patrick Sullivan and published by Elsevier. This book was released on 2005-08-01 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today's chemically dependent society, environmental studies demonstrate that drinking water in developed countries contains numerous industrial chemicals, pesticides, pharmaceuticals and chemicals from water treatment processes. This poses a real threat. As a result of the ever-expanding list of chemical and biochemical products industry, current drinking water standards that serve to preserve our drinking water quality are grossly out of date. Environmental Science of Drinking Water demonstrates why we need to make a fundamental change in our approach toward protecting our drinking water. Factual and circumstantial evidence showing the failure of current drinking water standards to adequately protect human health is presented along with analysis of the extent of pollution in our water resources and drinking water. The authors also present detail of the currently available state-of-the-art technologies which, if fully employed, can move us toward a healthier future.* Addresses the international problems of outdated standards and the overwhelming onslaught of new contaminants. * Includes new monitoring data on non-regulated chemicals in water sources and drinking water.* Includes a summary of different bottled waters as well as consumer water purification technologies.
Download or read book Protein Kinases in Drug Discovery written by Rossen Donev and published by Academic Press. This book was released on 2021-03-11 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more. Contains timely chapters written by well-renown authorities in their field Includes a number of high-quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students Integrates experimental and computational methods for studying the role of protein kinases in different diseases, along with sections on the design of suitable protein kinase inhibitors for use in the treatment of patients
Download or read book Congenital and Acquired Bone Marrow Failure written by Mahmoud Deeb Aljurf and published by Elsevier. This book was released on 2017-01-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.
