Download or read book Somatostatin and Its Receptors written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Download or read book Handbook of Neuroendocrinology written by George Fink and published by Academic Press. This book was released on 2012 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Download or read book The Pharmacological and Cellular Effects of Human Somatostatin Receptor Homo and Heterodimerization written by Michael Grant and published by . This book was released on 2008 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gigantism and Acromegaly written by Constantine A. Stratakis and published by Academic Press. This book was released on 2021-06-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
Download or read book Symposium The Biological and Clinical Relevance of the Somatostatin Receptor written by Irvin M. Modlin and published by . This book was released on 1997 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Somatostatin Analogues written by Alicja Hubalewska-Dydejczyk and published by John Wiley & Sons. This book was released on 2015-06-11 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research Covers topics by authors who are renowned experts and researchers in the field
Download or read book Somatostatin written by Coimbatore B. Srikant and published by Springer Science & Business Media. This book was released on 2004-06-17 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Each chapter is written by expert(s) active in somatostatin research (experimental and/or clinical) - It will serve as the only single one-stop source of the most up to date information on the basic and clinical aspects of the biology of somatostatin
Download or read book Somatostatin Analogues written by Alicja Hubalewska-Dydejczyk and published by John Wiley & Sons. This book was released on 2015-06-22 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research Covers topics by authors who are renowned experts and researchers in the field
Download or read book Nuclear Medicine The Requisites written by Harvey A. Ziessman, MD and published by Elsevier Health Sciences. This book was released on 2013-03-21 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the essential tools you need to make an accurate diagnosis with Nuclear Medicine: The Requisites! The newest edition of his bestselling volume by Drs. Harvey Ziessman, Janis O'Malley, and James Thrall delivers the conceptual, factual, and interpretive information you need for effective clinical practice in nuclear medicine imaging, as well as for certification and recertification review. Prepare for the written board exam and for clinical practice with critical information on nuclear medicine physics, detection and instrumentation, SPECT and PET imaging, and clinical nuclear medicine imaging. Get the best results from today's most technologically advanced approaches, including hybrid imaging, PET/CT, and SPECT/CT, as well as recent developments in instrumentation, radiopharmaceuticals, and molecular imaging. Clearly visualize the findings you're likely to see in practice and on exams with nearly 200 vibrant new full-color images. Access the fully searchable text and downloadable images online at www.expertconsult.com.
Download or read book Meningiomas E Book written by M. Necmettin Pamir and published by Elsevier Health Sciences. This book was released on 2010-01-25 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meningiomas, by M. Necmettin Pamir, MD, Peter M. Black, MD, PhD, and Rudolf Fahlbusch, MD, presents current and comprehensive guidance on this most common, yet clinically challenging type of brain tumor. Written and edited by the world’s most prominent brain tumor neurosurgeons, it helps you to not only determine the type and location of the tumor, but also the most ideal surgical approach to provide your patients with the best outcomes. An extensive collection of surgical photographs covers unique and original cases, while discussions of pre-surgical techniques and approaches emphasize decision making with the help of all imaging modalities and analysis of symptoms and patient history. Expert Consult functionality enhances your reference power with convenient online access to the complete text and illustrations from the book, along with videos that depict surgical techniques in real time. Provides access to the complete text online—fully searchable, along with all of the illustrations downloadable for your personal presentations, and real-time surgical videos covering microscopic extended endonasal approach to suprasellar meningioma, and more, at expertconsult.com. Covers today’s full range of management methods, including adjuvant therapies, providing you with the best strategies for obtaining optimal outcomes. Features the work of the world’s most prominent brain tumor neurosurgeons—a completely international authorship—bringing you the best procedures globally. Offers an in-depth section on surgical methods and approaches based upon tumor location, to help you in the decision-making process. Includes coverage of spinal meningiomas including pre-diagnosis symptoms and outcomes.
Download or read book Growth Hormone in Adults written by Anders Juul and published by Cambridge University Press. This book was released on 2000-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.
Download or read book Properties of Somatostatin Receptor Subtypes written by Karen Lee Raynor and published by . This book was released on 1992 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Canine and Feline Endocrinology E Book written by Edward C. Feldman and published by Elsevier Health Sciences. This book was released on 2014-11-14 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: No other title offers such dedication to the depth, experience, and focus of endocrinology as Canine and Feline Endocrinology, 4th Edition. Comprehensive coverage includes virtually every common and uncommon condition in endocrinology, plus the most updated information on nutrition, geriatric care, pathophysiology, testing procedures, and cost-effective and expedient diagnostic protocols. With its logical, step-by-step guidance for decision making, diagnosis, and prescribing, you will be well-equipped to care for the wide spectrum of endocrine and metabolic disorders in dogs and cats. Expert authorship, including the addition of three world-renowned endocrinology experts — Claudia Reusch, Catharine Scott-Moncrieff, and Ellen Behrend — offers unparalleled guidance on the latest advances in the field. Separation of cats and dogs into separate chapters ensures information on each species is covered to its fullest. Focus on diagnosis and treatment with less discussion on anatomy and physiology allows the book to concentrate on practical, current information that today’s clinician most use. Thorough coverage of indications and interpretation of testing procedures in endocrine diseases enables reliable and accurate diagnosis. Detailed discussions of diagnostic strategies and treatment recommendations provide practical, cost-effective, and expedient approaches while ensuring they represent standard of care backed by research and experience. Algorithms on diagnostic and therapeutic approaches provide a practical, logical resource for the busy practitioner needing quick access to information. Logical, step-by-step guidelines aid in accurate decision-making and diagnosis. Comprehensive tables and boxes summarize and clarify key information for quick reference. In-depth discussions from experts in the field include coverage of treatment, monitoring, and management of complications as well as clinical signs, differential diagnoses and diagnostic approaches Extensive reference lists provide readers with sources for additional information on clinical investigative studies Separate chapters devoted to each key topic provide thorough, distinct coverage of all content areas. NEW! Updated content includes the latest information on: thyroid disease; current imaging studies; atypical Addison's disease; atypical Cushing's disease; idiopathic hypercalcemia in cats; insulin therapy in dogs and cats; diagnostics and treatments; and radiotherapy. NEW! Integration of sound nutrition practices into the treatment of endocrine disorders ensures that you have the knowledge you need to efficiently treat these disorders. NEW! Expanded coverage provides more information on geriatric dogs and cats and the latest findings regarding the treatment of diabetes (two factors which are often interrelated).
Download or read book Biology of Somatostatin and Somatostatin Receptors in Breast Cancer written by Yogesh Patel and published by . This book was released on 1997 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: The longterm goal of our work is to elucidate the pattern of expression of the five somatostatin receptor (SSTR1-5) isoforms in breast cancer, to determine which SSTR subtypes and signalling mechanisms mediate the antiproliferative effects of somatostatin (SST), whether the available SST analogs are effective in binding to these antiproliferative SSTR subtypes, and whether the pattern of SSTR expression in tumors can provide an independent prognostic marker. Towards these goals, we have characterized the pattern of expression and relative abundance of mRNA and proteins for SSTR1-5 in 101 primary breast cancers. All tumors expressed at least one SSTR and the majority expressed multiple SSTRs including subtypes 2, 3, and 5 which bind to octapeptide SST analogs. A good correlation was found between SSTR protein expression by immunocytochemistry and mRNA analysis by RT-PCR. SSTRs exert significant antitumor activity both by cytostatic and cytotoxic (apoptotic) actions in breast cancer cells. Apoptosis is dependent on estrogen receptor expression and is potentiated by tamoxifen. Apoptosis is induced uniquely via the SSTR subtype and is associated with induction of wild type p53 and of Bax and endonuclease 2. By contrast, the other four SSTR subtypes signal cell cycle arrest with the following rank order - SSTR5> SSTR2> SSTR4> SSTR1. These changes are associated with the induction of the retinoblastoma protein pRB and the cyclin-dependent kinase inhibitor p21.
Download or read book Regulation of Somatostatin Receptor Subtype 2 Trafficking in Endocrine Cells written by Walaa Alshafie and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The pituitary gland controls most endocrine functions in the body through secretion of five major hormones. The secretion of these hormones is under the control of releasing and inhibiting factors released from the hypothalamus. The neuropeptide somatostatin (SOM) is the major hypothalamic regulator of pituitary gland hormone secretion. Five receptor subtypes (SSTR1-5) bind and transduce SOM signaling. Because SSTR2 is the major receptor subtype, my goal was to understand the physiological trafficking of SSTR2 following SOM binding in neuroendocrine cells. Several observations had suggested that SSTR2 cell surface expression is regulated by SSTR5 co-expression. Thus, we aimed to understand how SSTR5 regulates SSTR2 trafficking by activating SSTR2 with a selective agonist (L-779,976) in the presence or absence of SSTR5. The results from this thesis demonstrate that SSTR5 does not regulate SSTR2 trafficking but rather agonistic property of L-779,976 is responsible for selective SSTR2 trafficking pattern induced by this agonist. Additionally, we demonstrated that following SOM binding, SSTR2 traffics to a juxta-nuclear compartment. Excitingly, the effort to characterize this compartment resulted in the identification of a new class of storage vesicles in pituitary cells homologous to GLUT4 storage vesicles present in myocytes and adipocytes. We called those vesicles GLUT4 like storage vesicles (GLSVs) and showed that they harbor internalized SSTR2 and they are responsible for the regulated surfacing of SSTR2 in response to activation of hypothalamic releasing factor receptors on pituitary cells. We demonstrate that this mechanism fine-tunes pituitary gland hormones release. Therefore, in this doctoral thesis we have provided a detailed characterization of SSTR2 trafficking and identified a new storage carrier in pituitary cells that stores internalized SSTR2 and contributes to the regulation of pituitary hormone secretion"--
Download or read book Somatostatin written by Allison Anderson and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Somatostatins (SST) form a family of cyclopeptides that are mainly produced by normal endocrine, gastrointestinal, immune and neuronal cells, as well as by certain tumours. By binding to G-protein-coupled receptors on target cells, SST act as neuromodulators and neurotransmitters, as well as potent inhibitors of various secretory processes and cell proliferation. In this book, the authors discuss the synthesis, mechanisms-of-action and physiological effects of somatostatins. Topics include the effects of somatostatin in animal models of retinal disease; radiolabelled somatostatin analogues for use in molecular imaging; somatostain analogs as a treatment for congenital hyperinsulinism; somatostain and its receptors in the mammalian cochlea; diagnostic accuracy of positron emission tomography with somatostatin analogues in gastroenteropancreatic and thoracic neuroendocrine tumours.
