Download or read book Solution and Solid Phase Synthesis of Isoxazoline Containing Heterocycles written by Kristin Ann Milinkevich and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: An efficient, multi-gram synthesis of a spiroisoxazolinoproline-based amino acid requiring minimal purification, delivering good cis:trans diastereoselectivity (ca. 1:4) and providing good yields is reported. Surface bound studies of the reduction of an aryl-nitro group in the presence of an isoxazoline ring with tin(II) dichloride dihydrate were undertaken to confirm the stability of the isoxazoline ring. Full derivitization of this spiroisoxazolinoproline-based amino acid scaffold was performed during the synthesis of a library. This work is described in Chapter 1. Condensation of 3-chloropentane-2,4-dione with thioamides gives 1-(thiazol-5-yl)ethanones and subsequent Wittig olefination followed by nitrile oxide 1,3-dipolar cycloaddition to the resulting prop-1-en-2-yl moiety delivers racemic 5-(thiazol-5-yl)-4,5-dihydroisoxazoles. Biological evaluation of these diheterocycles showed promising fungicidal activity. This work is described in Chapter 2. A route to 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles has been developed. Acid hydrazide starting materials underwent an EDC-mediated coupling with acrylic acid derivatives to form diacyl hydrazides. Cyclodehydration of the diacyl hydrazide in the presence of triphenylphospine and hexachloroethane gave 1,3,4-oxadiazoles. Lastly, in situ nitrile oxide formation and subsequent 1,3-dipolar cycloaddition to the exomethylene moiety delivered 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. Biological evaluation of these diheterocycles showed weak insecticidal activity. This work is described in Chapter 3. A library of novel, propeller-shaped dispirotriheterocyclic isoxazolinopiperidinochromanones is reported. Each rigid dispirotriheterocycle was prepared in five linear steps from commercially available tert-butyl 4-oxopiperidine-1-carboxylate plus various derivatives of 1-(2-hydroxyphenyl)ethanone, benzaldehyde oxime, and carboxylic acids. Computational chemistry was employed to analyze the three-dimensional geometries of these dispirotriheterocycles as well as to generate chemoinformatic bioavailability data. X-ray crystallographic structure determination verified the regioselectivity of the nitrile oxide 1,3-dipolar cycloaddition reaction. This work is described in Chapter 4. A route to spiroisoxazolinopiperidinylbenzamides has been developed. N-Boc-4-piperidone underwent a Wittig olefination and Boc deprotection followed by an ipso substitution with 4-fluoro-3-nitrobenzoic acid to yield the starting scaffold in excellent yields. Diversification of the acid with primary amines, followed by in situ nitrile oxide formation and subsequent 1,3-dipolar cycloaddition to the exomethylene moiety delivered the spiroisoxazolinopiperdine intermediates. Reduction of the arylnitro followed by acylation or reductive amination yielded the spiroisoxazolinopiperidinylbenzamide library. This work is described in Chapter 5.
Download or read book Combinatorial Synthesis of Hydantoin Library with Isoxazoline Heterocycle written by Kyung-Ho Park and published by . This book was released on 2000 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solid Phase Organic Synthesis written by Patrick H. Toy and published by John Wiley & Sons. This book was released on 2012-01-18 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.
Download or read book Coumarins Macrocycles and Indazoles written by Aaron Mills and published by . This book was released on 2005 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis of Isoxazol in es Via 1 3 dipolar Cycloaddition Other Heterocyclic Systems and Developments in Solid phase Organic Synthesis written by Robert E. Sammelson and published by . This book was released on 2001 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Heterocycles Via Cycloadditions I written by Stefan Bräse and published by Springer Science & Business Media. This book was released on 2008-07-21 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers hot topics of frontier research summarized by reputed scientists in the field.
Download or read book Solid Phase Synthesis of Heterocyclic Compounds written by Christophe Remy Hemmer and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Fluorous Chemistry written by John A. Gladysz and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the leading experts John Gladysz, Dennis Curran, and István Horváth, this handbook is the first to summarize all the essential aspects of this emerging field of chemistry. Whether the reader is seeking an introduction to the concept of fluorous biphase catalysis, summaries of partition coefficients involving fluorous and organic solvents, or information on the latest fluorous mixture separation techniques, this authoritative compilation of contributions, written by the world's top authors, provides key information needed for successfully working with the diverse and fascinating families of fluorous molecules. The large number of reliable experimental procedures in particular makes this the ideal guide for newcomers wanting to use this elegant method in the laboratory. In addition, experts will also find a wealth of important information concisely contained in one ready reference. The result is an indispensable resource for everyone currently working or intending to work in this field.
Download or read book Synthesis of Flavones Isoxazolines and Related Heterocycles written by Mark Francis Springsteel and published by . This book was released on 2003 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organic Synthesis Natural Products Isolation Drug Design Industry and the Environment written by Chhanda Mukhopadhyay and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-07-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, applications of various non-conventional solvents diversified in various fields such as organic synthesis, natural products, drug design, pharmaceuticals, dyes and agrochemical industries. This book consists of nine chapters, which present recent advances and applications of various non-conventional solvents in organic transformations, drug design and bioremediation. Environmental impacts of non-conventional solvents and comparison between traditional solvents and non-conventional solvents are also discussed in this book.
Download or read book Stimulating Concepts in Chemistry written by Fritz Vögtle and published by John Wiley & Sons. This book was released on 2000 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fresh ideas have always been a necessary ingredient for progress in chemistry. Without a continuous supply of stimulating ideas from creative researchers, there would be no new insights into the subject. But what are some of the ideas that pervade modern chemistry? The answer to this question is to be found in "Stimulating Concepts in Chemistry". In a collection of 24 essays, a group of leading researchers provides an overview of the most recent developments in their fields. Readers can find out about modern concepts in chemistry such as self-assembly, nanochemistry, and molecular machines. Moreover, many spectacular advances have been achieved from the fusion of chemistry with life and materials science - a development which is illustrated by contributions on enzyme mimics, molecular wires, and chemical sensors. Further, the essayists write about new nanomaterials, efficient methods in synthesis, and big biomolecules - indeed, many of the topics that have dominated some of the recent discussions in chemistry. This outstanding text makes use of a special layout to reflect the editors' aim of presenting concepts in the form of essays. Thus, the book is not merely another source of knowledge but is intended to stimulate readers to develop their own ideas and concepts. This format should help to make the book interesting to a wide range of scientists. Students of chemistry will benefit from the different style of presentation of their subject, while researchers in industry and academia will welcome the exciting way in which some of the most challenging concepts in modern chemistry are presented.
Download or read book The Combinatorial Index written by Barry A. Bunin and published by Elsevier. This book was released on 1998-04-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. - Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods - Serves as a laboratory manual for bench chemists - Includes a chapter on linkers to assist in choice of linking strategy - Discusses strengths and limitations of the various methods - Contains a structural index showing functional group transformations in solid-phase synthesis
Download or read book Progress in Heterocyclic Chemistry written by Gordon Gribble and published by Elsevier. This book was released on 2004-11-26 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the sixteenth annual volume of Progress in Heterocyclic Chemistry, and covers the literature published during 2003 on most of the important heterocyclic ring systems.This volume opens with two specialized reviews. The first covers 'Lamellarins: Isolation, activity and synthesis' a significant group of biologically active marine alkaloids and the second discusses 'Radical Additions to Pyridines, Quinolines and Isoquinolines'. The remaining chapters examine the recent literature on the common heterocycles in order of increasing ring size and the heteroatoms present.
Download or read book Solid phase Organic Synthesis SPOS of Heterocycles Preparation and Use of Functionalzed Cross linked Polymers as Solid phase Catalysts written by Beth Anne Lorsbach and published by . This book was released on 1999 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book I Combinatorial Solid phase Synthesis of Isoxasolinopyrroles II OBOC Small Molecule Combinatorial Library Encoded by Halogenated Mass tags written by Sung Hee Hwang and published by . This book was released on 2004 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fmoc Solid Phase Peptide Synthesis written by W. Chan and published by OUP Oxford. This book was released on 1999-12-16 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.
Download or read book Progress in Heterocyclic Chemistry written by G.W. Gribble and published by Elsevier. This book was released on 2001-10-16 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Heterocyclic Chemistry(PHC) is the thirteenth annual review of the literature, covering the work published on important heterocyclic ring systems during 2000. In this volume there are two specialized reviews. The first, by H. Ila, H. Junjappa and P.K. Mohanta, covers their work on annulation using ∝-oxoketene dithioacetals, a synthetic method that provides useful routes to an impressively wide range of fused heterocycles. The second, by R. N. Warrener, is on the synthesis of fused 7-azanorbornanes. The 7-azanorbornane structural unit is incorporated into a series of elegant polycyclic molecules with rigid geometry. The subsequent chapters, arranged by increasing heterocycle ring size, review recent advances in the field of heterocyclic chemistry with emphasis on synthesis and reactions.
