Download or read book Progress in Human African Trypanosomiasis Sleeping Sickness written by Michel Dumas and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.
Download or read book The Dreamers written by Karen Thompson Walker and published by Random House. This book was released on 2019-01-15 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BOOK REVIEW EDITORS’ CHOICE • An ordinary town is transformed by a mysterious illness that triggers perpetual sleep in this mesmerizing novel from the bestselling author of The Age of Miracles. “Stunning.”—Emily St. John Mandel, author of Station Eleven • “A startling, beautiful portrait of a community in peril.”—Entertainment Weekly NAMED ONE OF THE BEST BOOKS OF THE YEAR BY Glamour • Real Simple • Good Housekeeping One night in an isolated college town in the hills of Southern California, a first-year student stumbles into her dorm room, falls asleep—and doesn’t wake up. She sleeps through the morning, into the evening. Her roommate, Mei, cannot rouse her. Neither can the paramedics, nor the perplexed doctors at the hospital. When a second girl falls asleep, and then a third, Mei finds herself thrust together with an eccentric classmate as panic takes hold of the college and spreads to the town. A young couple tries to protect their newborn baby as the once-quiet streets descend into chaos. Two sisters turn to each other for comfort as their survivalist father prepares for disaster. Those affected by the illness, doctors discover, are displaying unusual levels of brain activity, higher than has ever been recorded before. They are dreaming heightened dreams—but of what? Written in luminous prose, The Dreamers is a breathtaking and beautiful novel, startling and provocative, about the possibilities contained within a human life—if only we are awakened to them. Praise for The Dreamers “Walker’s roving fictive eye by turns probes characters’ innermost feelings and zooms out to coolly parse topics like reality versus delusion. . . . [It has] the perfect ambiguous frame for a tense and layered plot.”—O: The Oprah Magazine “[Walker’s] gripping, provocative novel should come with a warning: may cause insomnia.”—People (Book of the Week) “Powerful and moving . . . written with symphonic sweep.”—The New York Times Book Review “2019’s first must-read novel . . . Alternately terrifying and moving . . . The Dreamers is overflowing with humanity.”—Jezebel “This is an exquisite work of intimacy. Walker’s sentences are smooth, emotionally arresting—of a true, ethereal beauty. . . . This book achieves [a] dazzling, aching humanity.”—Entertainment Weekly
Download or read book The Colonial Disease written by Maryinez Lyons and published by Cambridge University Press. This book was released on 2002-06-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: A case-study in the history of sleeping sickness, relating it to the western 'civilising mission'.
Download or read book African Sleeping Sickness written by Wanda Coleman and published by David R. Godine Publisher. This book was released on 1990 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Coleman is one of the decade's most moral poets, showing us in feverishly focused first- and third-person dramatic monologues the grim life of L.A.'s streets. It's impossible to paraphrase her colloquial, dynamic style ... Understanding does not mean, to Coleman, mild forgiveness, it means hot rage against those of any color who prey on others in pain. Contextualizing murder, rape, poverty, addiction showing us their human faces gives Coleman a 'shattered heart,' makes her feel 'thrown heart first into this ruin,' but the experience transforms the reader"--From Booklist review.
Download or read book Hunter s Tropical Medicine and Emerging Infectious Diseases E Book written by Edward T Ryan and published by Elsevier Health Sciences. This book was released on 2019-03-25 with total page 1265 pages. Available in PDF, EPUB and Kindle. Book excerpt: New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You'll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. - Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. - Provides new vaccine schedules and information on implementation. - Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. - Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. - Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. - Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
Download or read book A Naturalist on Lake Victoria written by Geoffrey Douglas Hale Carpenter and published by London : T.F. Unwin. This book was released on 1920 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sleep Disorders and Sleep Deprivation written by Institute of Medicine and published by National Academies Press. This book was released on 2006-10-13 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
Download or read book Encephalitis Lethargica written by Paul Bernard Foley and published by Springer. This book was released on 2018-02-07 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encephalitis lethargica (‘sleeping sickness’) was a mysterious disorder that swept the world in the decade following the First World War, before disappearing without its cause having been identified. Around 85% of its victims, predominantly children, adolescents and younger adults, survived the acute disorder, but most developed severe neurological syndromes, particularly severe post-encephalitic parkinsonism and other severe motor abnormalities, that incapacitated them for the remainder of their lives. Despite its brief history, encephalitis lethargica played a major role in a variety medical discussions between the two World Wars, as this epitome of neuropsychiatric disease – attacking both motor and mental functions – appeared just as the separation of neurology and psychiatry had reached a critical point. Encephalitis lethargica sufferers presented an unprecedented combination of neurologic and psychiatric symptoms – including previously puzzling phenomena primarily associated with schizophrenia and hysteria, as well as behavioral changes and attention deficit disorders in children – that not only underscored the unity of mind and movement in the CNS, but also illuminated the critical role played by subcortical structures in consciousness and other higher mental functions that had formerly been associated with the soul and more recently presumed to be localized to the human cerebral cortex. Encephalitis lethargica exerted a greater influence on clinical and theoretic neuroscientific thought between the two World Wars than any other single disorder and had an enduring impact upon neurology and psychiatry. This book will be of interest to an educated audience active or interested in clinical (neurology, psychiatry, psychology) or laboratory neuroscience, particularly those interested in neuropsychiatry, as well as to those interested in the history of the biomedical sciences.
Download or read book Asleep written by Molly Caldwell Crosby and published by Penguin. This book was released on 2010-03-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating look at a bizarre, forgotten epidemic from the national bestselling author of The American Plague. In 1918, a world war raged, and a lethal strain of influenza circled the globe. In the midst of all this death, a bizarre disease appeared in Europe. Eventually known as encephalitis lethargica, or sleeping sickness, it spread worldwide, leaving millions dead or locked in institutions. Then, in 1927, it disappeared as suddenly as it arrived. Asleep, set in 1920s and '30s New York, follows a group of neurologists through hospitals and asylums as they try to solve this epidemic and treat its victims-who learned the worst fate was not dying of it, but surviving it.
Download or read book Lords of the Fly written by Kirk A. Hoppe and published by Bloomsbury Publishing USA. This book was released on 2003-11-20 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: British sleeping sickness control in colonial Uganda and Tanzania became a powerful mechanism for environmental and social engineering that defined and delineated African landscapes, reordered African mobility and access to resources. As colonialism shifted from conquest to occupation, colonial scientists exercised much influence during periods of administrative uncertainty about the role and future of colonial rule. Impartial and objective science helped to justify the British civilizing mission in East Africa by muting the moral ambiguities and violence of colonial occupation. Africans' actions shaped systems of western scientific knowledge as they evolved in colonial contexts. Bridging what might otherwise be viewed as the disparate colonial functions of environmental and health control, sleeping sickness policy by the British was not a straightforward exercise of colonial power. The implementation of sleeping sickness control compelled both Africans and British to negotiate. African elite, farmers, and fishers, and British administrators, field officers, and African employees, all adjusted their actions according to on-going processes of resistance, cooperation and compromise. Interactions between colonial officials, their African agents, and other African groups informed African and British understandings about sleeping sickness, sleeping sickness control and African environments, and transformed Western ideas in practice.
Download or read book The Sleeping Beauties written by Suzanne O'Sullivan and published by Pan Macmillan. This book was released on 2021-04-01 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shortlisted for the Royal Society Science Book Prize 2021 'To compare any book to a Sacks is unfair, but this one lives up to it . . . I finished it feeling thrillingly unsettled, and wishing there was more.' James McConnachie, Sunday Times 'A study of diseases that we sometimes say are 'all in the mind', and an explanation of how unfair that characterisation is.' Tom Whipple, The Times Books of the Year In Sweden, refugee children fall asleep for months and years at a time. In upstate New York, high school students develop contagious seizures. In the US Embassy in Cuba, employees complain of headaches and memory loss after hearing strange noises in the night. These disparate cases are some of the most remarkable diagnostic mysteries of the twenty-first century, as both doctors and scientists have struggled to explain them within the boundaries of medical science and – more crucially – to treat them. What unites them is that they are all examples of a particular type of psychosomatic illness: medical disorders that are influenced as much by the idiosyncratic aspects of individual cultures as they are by human biology. Inspired by a poignant encounter with the sleeping refugee children of Sweden, Wellcome Prize-winning neurologist Suzanne O’Sullivan travels the world to visit other communities who have also been subject to outbreaks of so-called ‘mystery’ illnesses. From a derelict post-Soviet mining town in Kazakhstan, to the Mosquito Coast of Nicaragua via an oil town in Texas, to the heart of the Maria Mountains in Colombia, O’Sullivan hears remarkable stories from a fascinating array of people, and attempts to unravel their complex meaning while asking the question: who gets to define what is and what isn’t an illness? Reminiscent of the work of Oliver Sacks, Stephen Grosz and Henry Marsh, The Sleeping Beauties is a moving and unforgettable scientific investigation with a very human face. 'To compare any book to a Sacks is unfair, but this one lives up to it.' Sunday Times
Download or read book Arthropod Borne Diseases written by Carlos Brisola Marcondes and published by Springer. This book was released on 2016-11-09 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthropod borne diseases cause enormous morbidity and mortality in most countries, mostly in those situated in tropical areas, but also in temperate regions. This book provides organized information on all arthropod related diseases, to prevent suffering and deaths, for medical students and professionals. Since arthropod borne diseases are present in many regions of the world and can even surprise professionals and lays in non-endemic regions, like malaria in UK and Canada, the author and its many expert collaborators are sure that it will be essential in all hospitals, clinics and medical libraries around the world. As arthropod borne diseases of domesticated animals are very numerous and in some cases related to human diseases, they are also included in the book.
Download or read book Human Emerging and Re emerging Infections written by Sunit Kumar Singh and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 2365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.
Download or read book The Family That Couldn t Sleep written by D. T. Max and published by Random House. This book was released on 2006-09-05 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass. What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world. In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study. With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.
Download or read book Uveitis written by C. Stephen Foster and published by Springer Nature. This book was released on 2020-12-03 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing solely on uveitis care, this quick reference guide will provide a compiled and easy to navigate differential diagnosis – making an often daunting task for clinicians easier, quicker, and more accurate by using a concise outline format to list the most critical aspects of a disease entity. Uveitis: A Quick Guide to Essential Diagnosis opens with a Diagnosis Flowchart, so that the reader can select the most probable diagnoses based on patient’s history and exam. From there the reader can then quickly turn to the corresponding chapter to learn about the most critical aspects of the disease entity: epidemiology, characteristic exam and imaging findings, prognostic factors, and treatment options. This book is written for ophthalmic care providers including general ophthalmologists, subspecialists, fellows, residents and optometrists and features research and contributions from institutions that are global leaders in uveitis care.
Download or read book Proteins and Proteomics of Leishmania and Trypanosoma written by André L.S. Santos and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
Download or read book WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis written by World Health Organization and published by . This book was released on 2019 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human African trypanosomiasis (HAT), or sleeping sickness, is a parasitic infection that is almost invariably fatal unless treated. It is a neglected tropical disease that occurs in sub-Saharan Africa. The incidence of the disease is declining in response to intensive surveillance and control in endemic areas. As a result, HAT is among the neglected tropical diseases targeted by the World Health Organization (WHO) for elimination. WHO maintains exhaustive records of all declared cases; in 2018, a historically low number of cases (less than 1000) was reported. The remarkable progress in the control of gambiense HAT has relied on case-finding and curative treatment, a strategy that interrupts transmission by depleting the reservoir of parasites in humans. This has been combined occasionally with vector control activities. The subject of these guidelines, therefore, is of utmost importance for the continuation of progress to eliminate HAT. The recent approval of a new medicine (fexinidazole) for the treatment of gambiense HAT has opened new possibilities for the management of cases and thus warrants the new WHO recommendations contained herein. While studies of fexinidazole and other therapies are ongoing, these guidelines are considered interim guidelines until new information becomes available. This document focuses on the management of patients affected by gambiense HAT and constitutes an update to the WHO therapeutic guidance issued in 2013.
