Download or read book Skeletal Muscle Insulin Receptor Function and Glucose Uptake in Aging Rats written by Kristin Carlson Eiffert and published by . This book was released on 1991 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Insulin Receptor Function in Skeletal Muscle in Response to Diet Aging and Exercise written by Judy J. Boyd and published by . This book was released on 1990 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Muscle Metabolism written by Juleen R Zierath and published by CRC Press. This book was released on 2002-02-28 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav
Download or read book Effect of Age and Chronic Calorie Restriction on Muscle Glucose Transport in Female F344 Rats written by Eric William Kietzke and published by . This book was released on 1993 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alterations in Skeletal Muscle Insulin Receptor Function Pancreatic Islet Insulin Secretion and Skeletal Muscle Fatty Acid Composition in Genetically Obese Rats written by Stephanie Frances Greene and published by . This book was released on 1996 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Skeletal Muscle Metabolism in Exercise and Diabetes written by Erik A. Richter and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Copenhagen Muscle Research Centre was founded in 1994 with the support of a grant from the Danish National Research Foundation. Among the goals for the Centre is the organization of research symposia, with the aim of bringing a limited number ofintemation ally renowned scientists together to discuss the latest developments and perspectives in their field. The first Copenhagen Muscle Research Centre Conference was held in 1995 and dealt with cardiovascular regulation. The Second Copenhagen Muscle Research Centre Confer ence was held from October 23-26, 1997. The topic of the Symposium was Muscle Metabo lism: Regulation, Exercise, and Diabetes. Seventy invited scientists from all over the world discussed their latest research related to skeletal muscle metabolism. The speakers were asked to expand on their presentations and to write short, but comprehensive, chapters about their given topics. The result is 28 peer-reviewed and edited chapters covering many if not all aspects of muscle energy metabolism related to exercise and diabetes. Emphasis is on regulation of glucose and fatty acid metabolism and the mechanisms regulating their use as fuels for the muscle during exercise. In addition, abnormalities in the regulation of glucose metabolism in the diabetic state are described. However, amino acid and protein metabolism are also thoroughly discussed. We believe that this volume brings an unparralleled, up to date, and comprehensive review of the frontiers in muscle metabolism. Erik A.
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Download or read book The Effects of Ageing and High Fat Diet on the Gene Expression of Adrenomedullin and Its Receptor Components in Rat Skeletal Muscles and Adipose Tissues written by Hei-Man Chow and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "The Effects of Ageing and High-fat Diet on the Gene Expression of Adrenomedullin and Its Receptor Components in Rat Skeletal Muscles and Adipose Tissues" by Hei-man, Chow, 周熙文, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled The Effects of Ageing and High-Fat Diet on the Gene Expression of Adrenomedullin and its Receptor Components in Rat Skeletal Muscles and Adipose Tissues Submitted by Hei Man Chow for the Degree of Master of Philosophy at the University of Hong Kong In August 2007 Metabolic syndrome is characterized by obesity, hypertension, insulin resistance, dyslipidemia and atherogenesis. Insulin resistance is a state in which a given concentration of insulin produces a sub-optimal biological effect in target tissues of skeletal muscle, adipose tissue and liver. Despite reports about the presence of adrenomedullin (AM) in skeletal muscles and adipose tissues, and the effect of high-fat diet induced obesity on its expression, details of the effects of ageing on AM levels in rat have not been reported. Here, the effects of ageing and high-fat diet on the gene expression of AM and its receptor component proteins, the metabolic effects of AM on skeletal and adipose tissue and the regulation of AM gene expression by glucose and insulin are reported. Both ageing and high-fat diet reduce the gene expression of preproAM in the skeletal muscle and adipose tissue. For the gene expression of receptor component proteins in the skeletal muscle, calcitonin receptor-like receptor (CRLR) was reduced by both, but the receptor activity modifying protein (RAMP) 2 was only decreased on ageing. In the adipose tissue, significant reductions of gene expression were observed in all the receptor component proteins (CRLR, RAMP1, RAMP2 and RAMP3) from the ageing study only. Moreover, immunoreactive (ir-) AM peptide contents were decreased by the ageing and high-fat diet in both skeletal muscle and adipose tissue. All these changes might suggest a reduction of AM level and functions. Obesity is characterized by hyperinsulinemia and hyperglycemia. Ageing is also characterized by hyperinsulinemia. Hyperinsulinemia and hyperglycemia might affect the gene expression of AM in skeletal muscle and adipose tissue. We found a decrease in AM gene expression by insulin in vitro in the skeletal muscle, similar to the adipose tissue, as reported previously. However, glucose did not lead to any significant changes. These suggest the AM gene expression in the skeletal muscle and adipose tissue is under transcription control of insulin but not glucose. The changes in AM gene expression suggested that AM might play roles in the regulation of fuel metabolism in the skeletal muscle and adipose tissue. We extended the studies to the effects of AM on insulin-stimulated glucose uptake, and found that was inhibited by AM in both skeletal muscle and adipose tissue. Such effects were reversed by a specific AM blocker, hAM(22-52); as well as a specific protein kinase A blocker, H89. Lipolysis in adipose tissue was enhanced with AM. These findings showed the increase in AM might be a possible cause to the insulin resistance. DOI: 10.5353/th_b3876701 Subjects: Adrenomedullin Gene expression Adipose tissues Aging Food habits Rats - Physiology
Download or read book Post exercise Insulin Sensitivity in Rodent Skeletal Muscle written by Junghoon Kim and published by . This book was released on 2005 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Persistent Effects of Exercise of Skeletal Muscle Glucose Transport Across a Portion of the Life span of F344XBNNia Rats written by Carol A. Briggs-Tung and published by . This book was released on 1993 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Download or read book Influence of Calorie Restriction on Insulin Signalling and Glucose Transport in Skeletal Muscle of Rats written by David J. Dean and published by . This book was released on 1997 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effect of Age and Environmental Variables on Insulin Stimulated Glucose Uptake written by Diana Walker Wright and published by . This book was released on 1983 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
Download or read book Insulin Signaling written by George Grunberger and published by CRC Press. This book was released on 2003-09-02 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to provide a state-of-the-art reference for graduate researchers and students in diabetes and endocrinology. Insulin Signaling is a comprehensive study of the regulation of molecular events by insulin at a cellular level, utilizing experimental techniques ranging from molecular systems through phenotypic expression in transgenic and knockout models.
Download or read book The influence of diet and development on insulin sensitivity of skeletal muscle in the rat Studies of Insulin receptor and glucose transporter mRNAs written by Shona M. Wallace and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Influence of Calorie Restriction on Skeletal Muscle Glucose Metabolism and Insulin Sensitivity written by Annie C.. Gazdag and published by . This book was released on 1999 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
