Download or read book Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades written by Danilo Quartullo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LIU program at CERN is of paramount importance at international level. The program foresees a significant upgrade of the LHC injector chain to increase the luminosity of the LHC beam by a factor of ten after 2024, when the HL-LHC era will start. This thesis deals with longitudinal beam dynamics studies for two LHC injectors (PSB and SPS), the main goal being the analysis of beam instabilities in the HL-LHC scenario.
Download or read book High Luminosity Large Hadron Collider The New Machine For Illuminating The Mysteries Of The Universe Second Edition written by Lucio Rossi and published by World Scientific. This book was released on 2024-02-06 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the physics and technology of the High-Luminosity Large Hadron Collider (LHC), highlighting the most recent modifications that shaped the final configuration, which is now in the advanced stages of its construction.This new High-Luminosity configuration of the LHC is the major accelerator project of this decade and will give new life to the LHC after its first fifteen years of operation, allowing for more precise measurements of the Higgs Boson and extending the mass limit reach for new particles.The LHC is such a highly optimized machine that upgrading it requires breakthroughs in many areas. Unsurprisingly, the High-Luminosity LHC required a long R&D period to bring into life an innovative accelerator magnet, based on Nb3Sn and capable of generating fields in the 11-12 T range, as well as many other new accelerator technologies such as superconducting compact RF crab cavities, advanced collimation concepts, a novel powering technology based on high temperature superconducting links, and others.The book is a self-consistent series of papers, which addresses all technology and design issues. Each paper can be read separately as well. The first few papers provide a summary of the whole project, the physics motivation, and the accelerator challenges. Altogether, this book brings the reader to the heart of the technologies that will also be key for the next generation of hadron colliders.This book is an essential reference for physicists and engineers in the field of hadron colliders and LHC related issues and can also be read by postgraduate students.
Download or read book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS Directed Therapies written by Ludovica Monti and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.
Download or read book Agave negatively regulates YAP and TAZ transcriptionally and post translationally in osteosarcoma cell lines written by Maria Ferraiuolo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Previously published works indicate that Agave exhibits anticancer properties. In the present study, anticancer effects of Agave leaf extract were investigated in the OS cells, discovering that Agave inhibits cell growth and cell migration, and sensitizes OS cells to cisplatin (CDDP), to overcome chemoresistance. Agave’s mechanisms of action include an initial process in which Agave induces YAP/TAZ oncogenic protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription through NF-κB p65:p50 heterodimers deregulation. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.
Download or read book Multi drug resistant Klebsiella pneumoniae strains circulating in hospital setting written by Eleonora Cella and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings. In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.
Download or read book Towards Recognizing New Semantic Concepts in New Visual Domains written by Massimiliano Mancini and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being the leading paradigm in computer vision, deep neural networks are inherently limited by the visual and semantic information contained in their training set. In this thesis, we aim to design deep models operating with previously unseen visual domains and semantic concepts. We first describe different solutions for generalizing to new visual domains, applying variants of normalization layers to multiple challenging settings e.g. where new domain data is not available but arrives online or is described by metadata. In the second part, we incorporate new semantic concepts into pretrained deep models. We propose specific solutions for different problems such as multi-task/incremental learning and open-world recognition. Finally, we merge the two challenges: given images of multiple domains and categories, can we recognize unseen concepts in unseen domains? We propose an approach that is the first, promising step, towards solving this problem. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.
Download or read book Physics of Intensity Dependent Beam Instabilities written by King-Yuen Ng and published by World Scientific. This book was released on 2006 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive treatment of intensity dependent particle beam instabilities in accelerating rings. Written for researchers, the material is also suitable for use as a textbook in an advanced graduate course for students studying accelerator physics. The presentation starts with a brief review of the basic concept of wake potentials and coupling impedances in the vacuum chamber followed by a discussion on static and dynamic solutions of their effects on the particle beams. Special emphasis is placed separately on proton and electron machines. Other special topics of interest covered include Landau damping, BalakinOCoNovokhatskyOCoSmirnov damping, Sacherer''s integral equations, Landau cavity, saw-tooth instability, Robinson stability criteria, beam loading, transition crossing, two-stream instabilities, and collective instability issues of isochronous rings. After the formulation of an instability, readers are provided a thorough description of one or more experimental observations together with a discussion of the cures for the instability. Although the book is theory oriented, the use of mathematics has been minimized. The presentation is intended to be rigorous and self-contained with nearly all the formulas and equations derived."
Download or read book High Luminosity Large Hadron Collider HL LHC written by G.. Apollinari and published by . This book was released on 2017 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Elementary Particles Accelerators and Colliders written by Ugo Amaldi and published by Springer. This book was released on 2013-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: After a historical consideration of the types and evolution of accelerators the physics of particle beams is provided in detail. Topics dealt with comprise linear and nonlinear beam dynamics, collective phenomena in beams, and interactions of beams with the surroundings. The design and principles of synchrotrons, circular and linear colliders, and of linear accelerators are discussed next. Also technological aspects of accelerators (magnets, RF cavities, cryogenics, power supply, vacuum, beam instrumentation, injection and extraction) are reviewed, as well as accelerator operation (parameter control, beam feedback system, orbit correction, luminosity optimization). After introducing the largest accelerators and colliders of their times the application of accelerators and storage rings in industry, medicine, basic science, and energy research is discussed, including also synchrotron radiation sources and spallation sources. Finally, cosmic accelerators and an outlook for the future are given.
Download or read book The CERN Larg Hardron Collider written by Amos Breskin and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book LHC Design Report written by and published by . This book was released on 2004 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Large Hadron Collider written by Lyndon R. Evans and published by EPFL Press. This book was released on 2009-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the technology and engineering of the Large Hadron collider (LHC), one of the greatest scientific marvels of this young 21st century. This book traces the feat of its construction, written by the head scientists involved, placed into the context of the scientific goals and principles.
Download or read book Nuclear and Particle Physics written by Brian R. Martin and published by John Wiley & Sons. This book was released on 2011-08-31 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible introduction to nuclear and particle physics with equal coverage of both topics, this text covers all the standard topics in particle and nuclear physics thoroughly and provides a few extras, including chapters on experimental methods; applications of nuclear physics including fission, fusion and biomedical applications; and unsolved problems for the future. It includes basic concepts and theory combined with current and future applications. An excellent resource for physics and astronomy undergraduates in higher-level courses, this text also serves well as a general reference for graduate studies.
Download or read book Particle Physics Reference Library written by Stephen Myers and published by Springer Nature. This book was released on 2020-01-01 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third open access volume of the handbook series deals with accelerator physics, design, technology and operations, as well as with beam optics, dynamics and diagnostics. A joint CERN-Springer initiative, the "Particle Physics Reference Library" provides revised and updated contributions based on previously published material in the well-known Landolt-Boernstein series on particle physics, accelerators and detectors (volumes 21A,B1,B2,C), which took stock of the field approximately one decade ago. Central to this new initiative is publication under full open access.
Download or read book Design Study of the Large Hadron Collider LHC written by and published by . This book was released on 1991 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Search for Displaced Leptons in the ATLAS Detector written by Lesya Horyn and published by Springer. This book was released on 2023-02-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents a search for long-lived particles decaying into displaced electrons and/or muons with large impact parameters. This signature provides unique sensitivity to the production of theoretical lepton-partners, sleptons. These particles are a feature of supersymmetric theories, which seek to address unanswered questions in nature. The signature searched for in this thesis is difficult to identify, and in fact, this is the first time it has been probed at the Large Hadron Collider (LHC). It covers a long-standing gap in coverage of possible new physics signatures. This thesis describes the special reconstruction and identification algorithms used to select leptons with large impact parameters and the details of the background estimation. The results are consistent with background, so limits on slepton masses and lifetimes in this model are calculated at 95% CL, drastically improving on the previous best limits from the Large Electron Positron Collider (LEP).
Download or read book Lectures on QCD written by Frieder Lenz and published by Springer Verlag. This book was released on 1997 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a collection of pedagogically written articles on quantum chromodynamics. Based on lectures given over the past years to graduate students, the articles are ideally suited as an introduction into modern research. The book contains concepts and applications of lattice gauge theories, finite temperature field theory, an article on the method of sum rules in QCD, and so on. Furthermore axial anomalies, the Skyrme model and recent developments of supersymmetric QCD are discussed in depth. A second volume on phenomenology is in preparation.
