Download or read book Modeling of Physiological Flows written by Davide Ambrosi and published by Springer Science & Business Media. This book was released on 2012-10-31 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling the cardiovascular system or, more broadly, physiological flows.
Download or read book Wall Fluid Interactions in Physiological Flows written by M.W. Collins and published by WIT Press. This book was released on 2004-05-19 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: All fluid flow problems in the human body involve interaction with the vessel wall. This volume presents a number of studies where primarily mathematical modelling has been applied to a variety of medical wall-fluid interaction problems. The medical applications discussed are highly varied, while some key clinical areas are also addressed. Unusually, a number of important medical challenges involving fluid flow are considered in combination with the relevant solid mechanics. The complexity of addressing combined fluid flow and solid behaviour is viewed positively by the book’s distinguished contributors. For the researcher it offers new scope for developing and demonstrating a mastery of the scientific principles involved.
Download or read book Hemodynamical Flows written by Giovanni P. Galdi and published by Springer Science & Business Media. This book was released on 2008-04-17 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book surveys research results on the physical and mathematical modeling, as well as the numerical simulation of complex fluid and structural mechanical processes occurring in the human blood circulation system. Topics treated include continuum mechanical description; choice of suitable liquid and wall models; mathematical analysis of coupled models; numerical methods for flow simulation; parameter identification and model calibration; fluid-solid interaction; mathematical analysis of piping systems; particle transport in channels and pipes; artificial boundary conditions, and many more. The book was developed from lectures presented by the authors at the Oberwolfach Research Institute (MFO), in Oberwolfach-Walke, Germany, November, 2005.
Download or read book Simulation of Physiological Flows written by Alejandro Roldán-Alzate and published by . This book was released on 2008 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Three dimensional Physiological Flow Simulation on Multi box Computational Domains written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluid flow phenomena in biological systems are typically complex. The complexity is originated from, for example, non-Newtonian behavior of body fluids, complicated geometry, as well as the interaction of muscle and fluid. With the advent of modern computational technology, both in hardware and software, gradually these problems can be resolved. The present research illustrates two such examples. Grid generation is a branch of applied mathematics that is essential for conducting numerical simulation of fluid flow. In this research, a new grid generation technique is developed and implemented in a flow solver. This technique enables one to perform grid generation for complex geometry using only a single computational zone. Fluid flow can then be analyzed without iteration between zones. The scheme is based on the composite transformation of an algebraic mapping and a mapping governed by the Laplace equation. The governing equations for the grid generation are derived first and then solved numerically. The scheme used for solving the grid generating equations is an extension of the traditional three-dimensional Douglass-Gunn scheme. Areas of extension include the inclusion of mixed derivative terms as well as first-order derivative terms. A unique feature of the proposed grid generation scheme is the concept of multi-box computational domains. In this scheme, the physical domain is mapped onto a geometry composed of many boxes in the computational space, rather than a single box as the traditional method does. The numerical solution routine is adjusted accordingly to accommodate this new feature. Grids were generated for two model geometries using the proposed grid generation software. The graft model features one inflow conduit and two outflow conduits, while the left atrium (LA) model has four inflow conduits and one outflow conduit. Flow simulation was performed using the research code INS3D, which employs the method of artificial compressibility. This method transforms the Navier-Stokes equations into a hyperbolic-parabolic set by adding to them pseudo-pressure gradient terms. The scheme is then marched along the pseudo-time axis, until the velocity field becomes divergence-free. For the flow simulation in side the graft, the effect of Reynolds number and flow-division ratio is examined ... In summary, the present research demonstrates applications of computational fluid dynamics technique in the analysis of flow in biological system. A new grid generation technique is realized, and proved to be very useful in simulating these flows. Flow simulation results provide insights into the system and may be of use for clinic reference.
Download or read book Biology and Mechanics of Blood Flows written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2007-12-20 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases.
Download or read book Mathematical and Computer Modeling of Physiological Systems written by Vincent C. Rideout and published by . This book was released on 1991 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Applied Mathematical Models in Human Physiology written by Johnny T. Ottesen and published by SIAM. This book was released on 2004-02-01 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors discuss models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation. This is the only book available that analyzes up-to-date models of the physiological system at several levels of detail; both simple 'real-time' models that can be directly used in larger systems, and more detailed 'reference' models that show the underlying physiological mechanisms and provide parameters for and validation of simpler models. The book also covers two-dimensional modeling of the fluid dynamics in the heart and its ability to pump, and includes a discussion of modeling wave-propagation throughout the systemic arteries.
Download or read book Visualization and Simulation of Complex Flows in Biomedical Engineering written by Rui Lima and published by Springer Science & Business Media. This book was released on 2013-11-18 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the most recent advances in the application of visualization and simulation methods to understand the flow behavior of complex fluids used in biomedical engineering and other related fields. It shows the physiological flow behavior in large arteries, microcirculation, respiratory systems and in biomedical microdevices.
Download or read book Dimension Reduced Modeling of Blood Flow in Large Arteries written by Tobias Köppl and published by Springer Nature. This book was released on 2023-07-15 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains an in-depth and coherent treatment of dimension-reduced modeling of blood flows on the level of large vessels (macrocirculation). The authors reduce the complexity by combining a one-dimensional Navier-Stokes equation and a simplified FSI-concept. The influence of omitted vessels, which are subsequent to the outlets of larger vessels, is accounted for by systems of ordinary differential equations (0D models). The target audience primarily comprises research experts in the field of biomedical engineering, but the book may also be beneficial for graduate students alike.
Download or read book Modeling the Heart and the Circulatory System written by Alfio Quarteroni and published by Springer. This book was released on 2015-04-24 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.
Download or read book Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2013-01-11 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.
Download or read book Biological Flows written by Colin G. Caro and published by Springer. This book was released on 2013-12-19 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics has a distinguished history extending at least to the 16th Century. However the later half oftbis century has seen an explosion ofthe field with it being viewed as affering exciting challenges for physical scientists and engineers interested in the life sciences, and wonderful opportunities for life scientists eager to collaborate with physical scientists and engineers and to render their scientific work more fundamental. That the field is now weil established and expanding is demonstrated by the formation of a World Committee for Biomechanics and the success and large participation in the 1st and 2nd World Congresses of Biomechanics, held respectively in San Diego in 1990 and in Amsterdam in 1994. With more than 1350 scientific papers delivered at the 2nd World Congress, either within symposia or oral or poster sessions, it would have been out of the question to try to produce comprehensive edited proceedings. Moreover, we are confident that most of the papers have been or will be published in one ofthe excellentjoumals covering the field. But of effort contributed by the plenary lecturers and the tutorial we thought that the large amount and keynote speakers of various symposia deserved tobe recognised in the form of a specific publication, thus also allowing those unable to attend the presentatiops . . tC\ sh?r~ in the findings. Furthermore, we feel that there is now a need to review aspects 'oftlie freld.
Download or read book Control of Cell Fate in the Circulatory and Ventilatory Systems written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2011-11-01 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volumes 1 and 2 are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment. Volume 1 examined cellular features that allow adaptation to environmental conditions. Volume 2 begins with a survey of the cell types of the nervous and endocrine systems involved in the regulation of the vasculature and respiratory tract and growth factors. It then describes major cell events in the circulatory and ventilatory systems, such as cell growth, proliferation, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered.
Download or read book Cardiovascular Mathematics written by Luca Formaggia and published by Springer Science & Business Media. This book was released on 2010-06-27 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.
Download or read book Modeling and Simulation in Biomedical Engineering Applications in Cardiorespiratory Physiology written by Willem L. van Meurs and published by McGraw Hill Professional. This book was released on 2011-08-07 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation. A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications. Coverage includes: Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators “Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014 “This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.
Download or read book A Computer Code for Modeling Physiological Flows written by Byron Lavon Hansen and published by . This book was released on 2002 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
