Download or read book Signal Transduction and Human Disease written by Toren Finkel and published by John Wiley & Sons. This book was released on 2003-07-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Download or read book Signal Transduction Pathways Mechanisms and Diseases written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Download or read book Disease Pathways written by Anastasia P. Nesterova and published by Elsevier. This book was released on 2019-10-18 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Download or read book Signal Transduction written by Lorenzo F. Greco and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, auto-immune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms. This book presents the latest research in the field.
Download or read book Signal Transduction in Health and Disease written by Paul Greengard and published by Academic Press. This book was released on 1998-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the Ninth International Conference on Second Messengers and Phosphoproteins. Written by leading scientists - including two Nobel Laureates - the papers highlight contemporary advances in the rapidly evolving field of signal transduction. The findings presented are of vital significance to researchers in virtually all biomedical fields, including pharmacology, molecular biology, cell biology, biochemistry, the neurosciences, and physiology. The contributors offer new insights into fundamental cell signalling mechanisms and explore the role of these mechanisms in physiological and pathophysiological responses in a variety of systems. Coverage includes many topics that are currently under intensive study, such as growth factors and special signalling systems; protein phosphatases and metabolic pathways; calcium and ion channels; cyclic GMP and cyclic AMP; and receptors and G proteins.
Download or read book Focus on Signal Transduction Research written by Gavin McAlpine and published by Nova Publishers. This book was released on 2007 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Download or read book Introduction to Cellular Signal Transduction written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 1999 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanism of information transfer between cells is the subject of this text. In the past, aspects of this field were the domain of different disciplines, including endocrinology, neurochemistry, and pharmacology. However, in recent years, signal transduction has emerged as an independent discipline.
Download or read book Caveolae and Lipid Rafts Roles in Signal Transduction and the Pathogenesis of Human Disease written by Edward Bittar and published by Elsevier. This book was released on 2005-10-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Download or read book Trends in Signal Transduction Research written by Jennifer N. Meyers and published by Nova Publishers. This book was released on 2007 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Download or read book Mitogen Activated Protein Kinases written by Ritva Tikkanen and published by MDPI. This book was released on 2020-06-18 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.
Download or read book Regulation of Signal Transduction in Human Cell Research written by Nariyoshi Shinomiya and published by Springer. This book was released on 2018-02-15 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
Download or read book Tissue Specific Cell Signaling written by Joana Vieira Silva and published by Springer Nature. This book was released on 2020-05-29 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Hedgehog Gli Signaling in Human Disease written by Ariel Ruiz i Altaba and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Download or read book Cellular Signal Transduction in Toxicology and Pharmacology written by Jonathan W. Boyd and published by John Wiley & Sons. This book was released on 2019-04-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
Download or read book Smad Signal Transduction written by Peter Dijke and published by Springer Science & Business Media. This book was released on 2007-05-10 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Download or read book Cell Surface GRP78 a New Paradigm in Signal Transduction Biology written by Salvatore V. Pizzo and published by Academic Press. This book was released on 2018-03-20 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. - Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies - Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease - Provides four-color illustrations that facilitate the narrative
