Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures IV written by Michael Waters and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures.
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures V written by Shahbeg S. Sandhu and published by Springer. This book was released on 1987 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures III written by Michael D. Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures II written by Michael Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing.
Download or read book Genetic Toxicology of Complex Mixtures written by Michael D. Waters and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character ization and source apportionment were discussed as an aid to understand ing the origin and relative contribution of various kinds of complex mix tures to the ambient environment. Similarly, investigations of genotoxi cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects.
Download or read book Arctic and Alpine Mycology II written by Gary A. Laursen and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the summer of 1980, the First International symposium on Arctic and Alpine Mycology (ISAM-I) was held at the then extant Naval Arctic Research Laboratory near Barrow, Alaska, U.S.A., well within the Arctic Circle (Laursen and Ammirati, Arctic and Alpine Mycology. The First International symposium on Arcto-Alpine Mycology. Univ. Wash. Press, 1982). The facility is currently owned and operated by the Utkeagvik Inupiat community and is named the National Academic and Research Laboratory, thus retaining its acronym NARL. Twenty-five scientists participated in that historic first meeting. Their interests in the fungi spanned a vast geographic area of cold dominated habitats in both the northern and southern hemispheres that included four continents (N. and S. America, Eurasia,and Antarctica), nine countries, and numerous islands ranging from Greenland to Jan Mayen in the Svalbard group. ISAM-I helped to develop ongoing interests and initiate others. This is what ISAM-I founders hoped would happen. Asa result, the organizing committee for ISAM-II was formed. Its mandate was to: involve a maximum of one third new participants in future ISAM meetings: divide the responsibility for organizing future meetings at sites located in areas of interest to research thrusts in Arctic and alpine environments: keep the number of participants small enough to ensure manageability, taking full advantage of field collecting opportunities with minimal complications and cost.
Download or read book Nitroarenes written by Paul C. Howard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.
Download or read book Environmental Radon written by C.Richard Cothern and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is intended for the professional who is a newcomer to the area of environmental radon. It marks the first time that chapters on these subjects have been brought together in a single volume, and it is arranged so that anyone with some basic university-level chemistry and physics can develop a clear understanding of the different aspects involved. The volume is intended to serve as a supplementary textbook in public health, environmental, and health physics courses. It also can be used by the professional to get "up to speed" in this rapidly evolving field. The chapters are not necessarily a discussion of the latest research in this fast-moving field, but are intended to bring the reader to a level at which he can easily understand the current literature. At the back of this volume the reader will find the references for the individual chapters, a general list of reading materials, a glossary, an appendix describing the equations for radioactive decay for a series of progeny, a table of often used conversion factors, and the addresses and brief biographies of the authors and editors. Both historical and SI (International System) units are used throughout the book to provide information for the widest range of readers. Thanks go to Tom Hess for the idea for this volume and to Jessica Barron for help in editing.
Download or read book In Situ Evaluation of Biological Hazards of Environmental Pollutants written by Shabeg S. Sandhu and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the relationship between environmental pollution and human health is in its infancy. The number of substances and mixtures that have been identified in uncontrolled hazardous waste sites or that have been in advertently released into the environment is large and data on how thes~ substances are modified as they interact with one another as they migrate through soil, air, and water are limited. There are also limits on our un derstanding of how these substances may be ingested, inhaled, or absorbed by people. The complexity of possible interactions between biological, chemical, and physical components in a given environment makes it virtually impossible to evaluate the potential for adverse biological effects ade quately in the laboratory. Other, more comprehensive methods which provide realistic and interpretable results must be used. Many scientists believe that humans represent the ultimate sentinel species of a toxic exposure re sUlting from environmental pollution, however such exposures may also se verely impact environmental health. There exists a wide variety of organ isms in the natural environment that could be used to provide an early warning for potential human health effects as well as to indicate adverse ecological effects. The issue of effective utilization of sentinel species for environment al monitoring is a rapidly developing area of research which has grown in importance during the last decade.
Download or read book Methods for Genetic Risk Assessment written by David Brusick and published by CRC Press. This book was released on 1994-01-11 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms. Topics considered include:
Download or read book Acid Rain Economic Assessment written by Paulette Mandelbaum and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, Proceedings of the Conference ACID RAIN: Economic Assessment, is meant to present the areas of agreement which economists have established and the uncertainties which they have discovered in their attempts to use the methodology of economics to better understand the nature of the acid rain issue. Scientific articles about acid rain initially appeared in 1972. The public turned its attention to the issue in the mid-1970s. In April 1979, the first acid rain bill was introduced in the Senate, authored by New York's Senator Daniel P. Moynihan. The bill sought to establish a federal research program dedicated to filling the gaps in understanding of the phenomena of long-range transport of air pollutants and their environmental, health and economic impacts. 'The bill was passed into law in 1980. Since then, tens of bills have been proposed to control emissions of S02 and NO , x thought to be the precursors of acid rain. And yet, in contrast with the pattern set by the majority of environmental issues, where legislation followed very quickly on the heels of public anxiety and involvement, by July 1985 not a single federal acid rain control bill had been passed.
Download or read book Hazards Decontamination and Replacement of PCB written by Jean-Pierre Crine and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poly Chlorinated Biphenyls (PCBs) are dielectric liquids which have been widely used in various industries for more than 50 years because of their supposed nonflammabi 1 i ty and thei r chemical inertness. Recent acc idents all over the world have shown PCBs can burn and their combustion by products (dioxines, furanes, etc.) are highly toxic. In fact, confusion has been created in the pub 1 ie mind between the dangers and hazards induced by PCBs themselves and those generated by their byproducts. Meanwhile, PCB pollution and toxicity is a major concern for regulating agencies, such as EPA in the United States and industry. Most Western countries now ban PCB production and strictly control their use. However, enormous amounts of PCB remain in use and their safe handling, destruction and replacement are heavy burdens for industrial users. PCB pollution and its side effects are the subject of various studies with recent conferences devoted to these PCB studies. Thus a large body of specialized information now exists on the environmental, medical, bio logical and safety aspects of PCB handling, use, cleaning and decontami nation. However, no single comprehensive publication is yet available which deals with all the problems associated with PCBs. The major objective of the present book is to provide such a guide for PCB users. One interest of this book is that it brings together the point of view of scientists from widely different backgrounds: biologists, physicians, environmentalists, toxicologists, chemists, electrical engineers, etc.
Download or read book Current Bibliographies in Medicine written by and published by . This book was released on 1988 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Download or read book Literature Search written by National Library of Medicine (U.S.) and published by . This book was released on 1984 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Toxicology Program Annual Report for Fiscal Year written by National Toxicology Program (U.S.) and published by . This book was released on 1991 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fundamentals Of Aquatic Toxicology written by Gary M. Rand and published by CRC Press. This book was released on 2020-08-06 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.
