Download or read book Shh Signaling in Limb Development written by Jiang Liu and published by . This book was released on 2013 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interaction of FGF and SHH Signaling in Limb Development written by Zhen Zhang and published by . This book was released on 2009 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epithelial mesanchymal Interactions written by Raul Fleischmajer (ed) and published by . This book was released on 1968 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulators of Shh Signaling in Limb Patterning and Development written by Olena Zhulyn and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The embryonic limb is one of the best understood examples of pattern formation in vertebrates. Patterning, along its anterior-posterior (AP) and proximo-distal (PD) axes, has been studied almost exclusively within the framework of positional information - the idea that the fate of individual cells is determined by their positional value in an embryonic field. This value is conferred through signaling molecules, called morphogens, in a concentration dependent manner. This idea is best illustrated in the chick wing whose AP pattern is imposed by an organizing center called the "zone of polarizing activity" (ZPA), through secretion of the morphogen Sonic hedgehog (Shh). Studies over the past 20 years show that Shh regulates patterning and growth through regulation of Gli-family transcription factors. The mouse has been an excellent genetic model for the study of Shh-mediated limb patterning and signal transduction, as well as the pathway's role in development and disease. However, these studies have also revealed critical differences between the mouse and chick models resulting in a need to re-evaluate positional information as a universal framework for vertebrate development. In this thesis, I propose the two-population model as a complimentary framework that allows us to reconcile the discrepancies of existing models. Using genetic models in the mouse, and pharmacological manipulation in the chick, I demonstrate that specific changes in Gli activity produce a defined spectrum of limb malformations and I utilize this spectrum as a tool to study a previously uncharacterized component of the Shh signal cascade, the receptor Ptch2, demonstrating that it is a critical, context-dependent regulator of the Shh signaling receptor Smoothened. This body of work illustrates that the vertebrate limb remains a prescient model for the study of signal transduction, development and disease and opens the door for the study of universal mechanisms of patterning in vertebrate organisms.
Download or read book HOX Gene Expression written by Spyros Papageorgiou and published by Springer Science & Business Media. This book was released on 2007-08-28 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hox Gene Expression starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes, their evolution, structure, normal and abnormal function. Researchers and graduate students in biology and medicine will benefit from this integrated overview of Hox gene activities.
Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
Download or read book Shh and Gli Signalling in Development written by Sarah Howie and published by Springer Science & Business Media. This book was released on 2008-05-24 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (shh) pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.
Download or read book Hedgehog Gli Signaling in Human Disease written by Ariel Ruiz i Altaba and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Download or read book Vertebrate Limb and Somite Morphogenesis written by British Society for Developmental Biology and published by CUP Archive. This book was released on 1977-12-22 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Avian Embryology written by and published by Academic Press. This book was released on 2011-09-21 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised edition will continue to serve as the most complete and up-to-date guide to the use of the avian embryo in studies of vertebrate development. It will include new approaches to analysis of the chick genome, gene knock-out studies using RNA interference, morpholinos, and other cutting edge techniques. As with the original edition, emphasis has been placed on providing practical guidance, highlighting potentials and pitfalls of all key cell biological and embryological techniques. *fully revised second edition *organized into basic and advanced Methods *new section on Functional Genomics
Download or read book Animal Anomalies written by Lewis I. Held, Jr and published by Cambridge University Press. This book was released on 2021-03-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights what we know about the pathways pursued by embryos and evolution, and stresses what we do not yet know.
Download or read book Long Range Control of Gene Expression written by Veronica van Heyningen and published by Academic Press. This book was released on 2011-09-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. Discusses the evolution of cis-regulatory sequences in drosophila Includes information on genomic imprinting and imprinting defects in humans Includes a chapter on epigenetic gene regulation in cancer
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signalling Pathways in Embryonic Development written by Juan J. Sanz-Ezquerro and published by Frontiers Media SA. This book was released on 2017-11-30 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.
Download or read book Fetal and Neonatal Lung Development written by Alan H. Jobe and published by Cambridge University Press. This book was released on 2016-04-18 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
