Download or read book Sex Differences in the Aging Brain written by Sivaniya Subramaniapillai and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The mechanisms underlying sex differences in many neurodegenerative conditions have been historically understudied, despite established sex differences in the prevalence of these conditions. For example, men are more likely to be diagnosed with Parkinson's Disease, while women are at greater risk of developing Alzheimer's disease (AD). In the case of AD, two-thirds of clinically diagnosed cases are women, emphasizing the importance of investigating sex-specific biological and gender-specific sociocultural factors that might increase women's AD risk. This thesis aims to characterize brain-aging differences of women and men throughout the adult lifespan, and the factors that differentiate typical aging from atypical cases, such as AD. Understanding individual differences, whether sex, gender, non-modifiable risk factors (e.g., family history of AD), or modifiable factors (e.g., education, physical exercise) can help to clarify the heterogeneity underlying brain-aging differences, and thus inform specialized health interventions based on individual differences. The thesis describes three studies investigating sex differences in the effect of age on brain structure, function, and cognition throughout the adult lifespan. In Study 1, we report sex differences in how age affected memory-related brain activity despite there being no differences in memory performance. Older women showed retrieval-related deficits in frontoparietal and medial temporal areas that was associated with worse memory performance but demonstrated compensatory recruitment of these areas at encoding to support their performance. In men, we found that older individuals were not able to successfully recruit semantic processing brain areas (i.e., ventral lateral prefrontal and ventral visual areas) that younger men were able to recruit for successful memory performance. In Study 2, we demonstrate that cognitively normal women and men may have varied brain-aging differences depending on the presence of non-modifiable risk factors, such as a family history of AD. Despite the negative consequences of AD risk factors to brain aging, we provide preliminary evidence indicating that modifiable factors, such as physical exercise and body mass index, can buffer against AD risk factors to protect against greater brain aging. In Study 3, we conducted a systematic literature review to determine what is known about sex and gender differences in lifestyle and demographic factors, such as education, occupation, and physical activity, in promoting healthy brain aging and reducing AD risk. We found some evidence indicating that these protective factors benefit women and men equally, and in some cases, women benefit more from engaging in these factors to lower their AD risk. Taken together, the findings across these studies highlight the importance of investigating sex and gender differences in healthy aging, and the role of modifiable and non-modifiable factors in contributing to differences in brain aging"--

Download or read book Sex and Gender Differences in Alzheimer s Disease written by Maria Teresa Ferretti and published by Academic Press. This book was released on 2021-07-23 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex and Gender Differences in Alzheimer’s Disease: The Women’s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer’s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer’s disease families, in the frame of a precision medicine approach to Alzheimer’s disease.This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer’s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer’s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer’s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer’s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer’s disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel

Download or read book Sex Differences in Brain Function and Dysfunction written by Claire Gibson and published by Springer Nature. This book was released on 2023-03-01 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mental health and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.

Download or read book Sex Differences in the Influence of Brain and Lifestyle Factors on Neurocognitive Aging written by Christina Joanne Van Den Brink and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Declines in executive functioning (EF) are a hallmark of neurocognitive aging. Much research has focused on the impact of exercise, brain structure, and brain function on neurocognitive aging, yet their relative predictive weights had not been evaluated. Further, the impact of sex differences on the influence of these factors had not yet been investigated. Fifty-one older adults participated in this study evaluating the outcome of cardiorespiratory fitness (CRF), prefrontal cortex volume, and global efficiency of functional brain networks on EF. A stratified, multiple hierarchical regression was performed to identify the best predictors of EF for each sex. For females, a model containing solely CRF served as the best predictor of EF. A model containing both CRF and network efficiency best predicted EF in males. These results demonstrate that CRF and metrics of structural and functional brain health in older adulthood are independently associated with EF in a sex-dependent manner.

Download or read book Sex Differences in Neurology and Psychiatry written by and published by Elsevier. This book was released on 2020-09-30 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders. Explores sex differences in human neuroanatomy and neurophysiology Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context

Download or read book Cognitive Sex Differences in Normal and Pathological Aging written by Paula Kay Shear and published by . This book was released on 1991 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Sex Differences in the Brain written by Jill B. Becker and published by Oxford University Press. This book was released on 2007-12-04 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the basic and clinical biomedical research community, there is increasing recognition that differences between males and females across the lifespan affect an individual's health, his/her development of disease, signs and symptoms of pathophysiology, and response to therapy. This book is intended as a resource for scientists, clinicians, and students of the nervous system and behavior- a trove of practical information about how to study sex differences in the brain as well as a discussion of what is already known on the topic.

Download or read book Pink Brain Blue Brain written by Lise Eliot and published by Houghton Mifflin Harcourt. This book was released on 2009 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: A neuroscientist shatters the myths about gender differences, arguing that the brains of boys and girls are largely shaped by how they spend their time, and offers parents and teachers concrete ways to avoid reinforcing harmful stereotypes.

Download or read book Physical Activity and the Aging Brain written by Ronald Ross Watson and published by Academic Press. This book was released on 2016-12-15 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function is a complete guide to the manifold effects of exercise and physical activity on the aging brain. Cognitive decline and motor impairment, onset of diseases and disorders, and even changes in family structure and social settings that occur as we age can all impact activity levels, yet continued physical activity is crucial for successful neurological functioning. This book examines the role that exercise and physical activity play in halting or modulating the deleterious effects of these numerous aging concerns by first examining the current state of research into how exercise manifests physical changes in the brain. It then discuss how physical activity combines with other lifestyle factors to benefit the aging brain, including nutrition, computerized brain training, and social engagement. Most significantly, it also covers how physical activity can serve as therapy to help alleviate the symptoms of various neurological diseases impacting aging populations, with particular emphasis on Alzheimer’s disease and age-related cognitive decline. The book provides broad coverage of the effects of exercise and physical activity on the aging brain, its therapeutic effects, and the many factors that influence the aging process. Presents research scientists with a complete understanding of the role of exercise in healthy brain aging Considers the roles of nutrition, the mind-body connection, and other lifestyle factors Presents a major resource for exercise and physical activity in the neurological health of older adults Provides a synopsis of key ideas associated with the many aspects of physical activity, along with lifestyle factors that can modify neurological diseases and age-related neurological decline

Download or read book Mitochondrial Function written by William S. Allison and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Brain Training written by Syrie Gallows and published by Self Publisher. This book was released on 2020-07-08 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are cognitive functions? How does our brain work? What facts and myths about our minds are out there, and which should you believe? These and several other questions will be answered in this comprehensive manual. You will also learn about the sex differences pertaining to the human brain, how those differences manifest themselves in children’s play, and other topics that relate to our cognizant awareness. Pick up this book now and learn more!

Download or read book The Male and Female Brain Molecular Mechanisms of Sex Differences written by Laura Musazzi and published by Frontiers Media SA. This book was released on 2021-12-30 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Microcircuits written by Sten Grillner and published by MIT Press. This book was released on 2006 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits. The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists. Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste

Download or read book The Female Brain written by Louann Brizendine, MD and published by Harmony. This book was released on 2007-08-07 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Dr. Brizendine wrote The Female Brain ten years ago, the response has been overwhelming. This New York Times bestseller has been translated into more than thirty languages, has sold nearly a million copies between editions, and has most recently inspired a romantic comedy starring Whitney Cummings and Sofia Vergara. And its profound scientific understanding of the nature and experience of the female brain continues to guide women as they pass through life stages, to help men better understand the girls and women in their lives, and to illuminate the delicate emotional machinery of a love relationship. Why are women more verbal than men? Why do women remember details of fights that men can’t remember at all? Why do women tend to form deeper bonds with their female friends than men do with their male counterparts? These and other questions have stumped both sexes throughout the ages. Now, pioneering neuropsychiatrist Louann Brizendine, M.D., brings together the latest findings to show how the unique structure of the female brain determines how women think, what they value, how they communicate, and who they love. While doing research as a medical student at Yale and then as a resident and faculty member at Harvard, Louann Brizendine discovered that almost all of the clinical data in existence on neurology, psychology, and neurobiology focused exclusively on males. In response to the overwhelming need for information on the female mind, Brizendine established the first clinic in the country to study and treat women’s brain function. In The Female Brain, Dr. Brizendine distills all her findings and the latest information from the scientific community in a highly accessible book that educates women about their unique brain/body/behavior. The result: women will come away from this book knowing that they have a lean, mean, communicating machine. Men will develop a serious case of brain envy.

Download or read book The Cambridge Handbook of the International Psychology of Women written by Fanny M. Cheung and published by Cambridge University Press. This book was released on 2020-08-06 with total page 1524 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing knowledge base in understanding the differences and similarities between women and men, as well as the diversities among women and sexualities. Although genetic and biological characteristics define human beings conventionally as women and men, their experiences are contextualized in multiple dimensions in terms of gender, sexuality, class, age, ethnicity, and other social dimensions. Beyond the biological and genetic basis of gender differences, gender intersects with culture and other social locations which affect the socialization and development of women across their life span. This handbook provides a comprehensive and up-to-date resource to understand the intersectionality of gender differences, to dispel myths, and to examine gender-relevant as well as culturally relevant implications and appropriate interventions. Featuring a truly international mix of contributors, and incorporating cross-cultural research and comparative perspectives, this handbook will inform mainstream psychology of the international literature on the psychology of women and gender.

Download or read book From Sex Differences in Neuroscience to a Neuroscience of Sex Differences New Directions and Perspectives written by Belinda Pletzer and published by Frontiers Media SA. This book was released on 2015 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research topic aims to integrate scattered findings on sex differences in neuroscience into a broader theory of how the human brain is shaped by sex and sex hormones in order to cause the great variety of sex differences that are commonly observed. It can be assumed that these differences didn’t occur arbitrarily, but that they rather determined and still determine evolutionary success of individuals and were shaped by the processes of natural and in particular sexual selection. Therefore, sex differences are not negligible and sex difference research cannot be discriminating against one sex or the other. In fact a better understanding of the underlying causes of sex differences has great advantages for both men and women and society as a whole, not only in terms of health care, but in every aspect of life. Gender equality can only work out if it is equally well understood for men and women what their individual resources and needs are. Therefore, it is of great importance to pave the way for identifying the underlying principles of structural and functional brain organization that cause men and women to act, think and feel differently. To this end it is of particular interest to identify possible similarities and interrelations between sex differences that did so far stand separately, in order to investigate whether they share a common source. To understand, where a specific sex difference comes from and whether or not it is caused by the same principle as other sex differences, it is necessary to explicitly link sex differences in behavior to their neuronal correlates and vice versa link sex differences in brain structure and function to their behavioral outcomes. In particular a new understanding of male and female brain functioning may arise from findings on how sex hormones interact with various neurotransmitter systems. In the past few years several findings demonstrated that women’s behavior is influenced by the sex hormone fluctuations they experience naturally during their menstrual cycle to the extent that sex differences may only be detectable in one cycle phase but not another. The study of menstrual cycle dependent effects gives important hints about which sex differences are activational and which are organizational. Additionally it only recently came to attention, that hormonal contraception may alter a women’s mood, cognition and behavior as a consequence of changes in brain structure and function. The underlying mechanisms are so poorly understood that it is even hard to predict, whether hormonal contraception will mask or amplify sex differences in a given task. Since the oral hormonal contraceptive pill is meanwhile used by 100 million women worldwide and even by teenagers whose brains are not yet fully developed, the question of how the synthetic steroids contained in hormonal contraceptives act on the brain is to be studied hand in hand with naturally occurring sex differences. This topic summarizes the current state of the art in sex difference research and gives new perspectives in terms of hypothesis generation an methodology. Both are necessary to gain a complete picture of what it is that makes a brain male or female and move towards a neuroscience of sex differences.

Download or read book Brain Storm written by Rebecca M. Jordan-Young and published by Harvard University Press. This book was released on 2011-10-15 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Female and male brains are different, thanks to hormones coursing through the brain before birth. That’s taught as fact in psychology textbooks, academic journals, and bestselling books. And these hardwired differences explain everything from sexual orientation to gender identity, to why there aren’t more women physicists or more stay-at-home dads. In this compelling book, Rebecca Jordan-Young takes on the evidence that sex differences are hardwired into the brain. Analyzing virtually all published research that supports the claims of “human brain organization theory,” Jordan-Young reveals how often these studies fail the standards of science. Even if careful researchers point out the limits of their own studies, other researchers and journalists can easily ignore them because brain organization theory just sounds so right. But if a series of methodological weaknesses, questionable assumptions, inconsistent definitions, and enormous gaps between ambiguous findings and grand conclusions have accumulated through the years, then science isn’t scientific at all. Elegantly written, this book argues passionately that the analysis of gender differences deserves far more rigorous, biologically sophisticated science. “The evidence for hormonal sex differentiation of the human brain better resembles a hodge-podge pile than a solid structure...Once we have cleared the rubble, we can begin to build newer, more scientific stories about human development.”