Download or read book Serotoninergic Neurons and 5 HT Receptors in the CNS written by H.G. Baumgarten and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Download or read book Serotonin Receptors in Neurobiology written by Amitabha Chattopadhyay and published by CRC Press. This book was released on 2007-05-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l

Download or read book Serotonin and Sleep Molecular Functional and Clinical Aspects written by Jaime M. Monti and published by Springer Science & Business Media. This book was released on 2008-03-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.

Download or read book The Serotonin Receptors written by Bryan L. Roth and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Download or read book Handbook of Neurochemistry written by Abel Lajtha and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuronal Serotonin written by N. N. Osborne and published by . This book was released on 1988-06-03 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph presents wide-ranging views on the roles of serotonin in various functions, such as sleep, pain, and behavior, as well as new developments in serotonin research. Placing major emphasis on serotonin receptors, it examines the progress made in scientific understanding in the field, including coverage of specific receptors linked to the utilization of inositol phosphate(s) as a second messenger, peripheral serotonin receptors, the production and clinical significance of targeted antagonists to these receptors, and evidence supporting the presence of at least five types of serotonin receptors in the mammalian nervous system, including various experimental strategies and findings on their functional significance.

Download or read book Serotonin Neurotransmitter and Hormone of Brain Bowels and Blood written by Kaneez Fatima-Shad and published by BoD – Books on Demand. This book was released on 2024-06-19 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin is an amazing neurotransmitter and hormone that is not only responsible for mood regulation but also plays an important role in regulating various aspects of human physiology and directly affecting human health. Serotonin is key to providing nutrition and oxygen from head to toe through vasoconstriction and hemostasis. The chapters in this book describe in detail not only how the serotonin receptor network interacts with each other but also their role in various pathologies. Disorders of serotonin could be related to structural and/or functional damage to the blood, brain, and bowel. Early identification of these conditions could benefit many diseases such as atherosclerosis, stroke, depression, and irritable bowel syndrome. The effects of serotonin abnormalities extend beyond one’s intellectual capacity. These effects can be felt at any time, from embryonic life to old age. In this book, you will not only find the role of other hormones such as insulin on serotonin but will also learn how serotonin plays an essential role in both plants and animals.

Download or read book Serotonin Molecular Biology Receptors and Functional Effects written by FOZARD and published by Birkhäuser. This book was released on 2012-12-06 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second IUPHAR Satellite Meeting on Serotonin was held under the auspices of the Serotonin Club in Basel, Switzerland in July 1990. The scope was wide, ranging from molecular biology through in vitro and in vivo pharmacology to new drug tools and their clinical signifi cance. There were three invited review lectures, by J. M. Palacios, D. I. Wallis and A. Kaumann, and S. Peroutka gave the first Serotonin Club Irvine H. Page Lecture. The rest of the oral programme was put together by the Scientific Organizing Committee based on volunteered research contributions. The invited review lecturers, the platform speak ers and selected poster contributors were invited to write up their contributions for inclusion in this volume. Most complied and this book is the result of their efforts. When instructing the authors prior to the meeting, we emphasized that selected new data should be put in the context of the literature findings. In this way we hoped to achieve topicality yet preserve the review perspective which facilitates its appreciation by the non-special ist. It was truly a pleasure to read the interesting papers which resulted and to prepare them for publication. We believe they convey to a remarkable degree the spirit of what was generally felt to be a highly stimulating exchange of information on matters serotonergic which took place in Basel last July.

Download or read book 5 HT4 Receptors in the Brain and Periphery written by Richard M. Eglen and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, up-to-date review of the distribution, pharmacology and physiology of central 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes exhibit a unique pharmacology, distribution and function, of which the 5-HT4 receptor has been one of the most intensively studied in recent years, both from a basic research standpoint and as a target for novel therapeutics.

Download or read book Handbook of the Behavioral Neurobiology of Serotonin written by Christian P. Muller and published by Academic Press. This book was released on 2009-12-30 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. - The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system - Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others - The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community - Of great value not only for researchers and experts, but also for students and clinicians as a background reference

Download or read book Serotonin written by Paul M. Pilowsky and published by Academic Press. This book was released on 2018-09-21 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and for growth and development in early life. This important resource highlights serotonin’s role in normal (unstressed) conditions, and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. In addition, the book compares and contrasts the physiological effects of brain and blood serotonin systems and includes new data suggesting that the influence of serotonin is in part through the regulation of gene expression. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension, and presents compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS). Includes the latest information on new animal models of serotonin system dysfunction Explores the wide scope of serotonin’s influence on multiple organ and physiological systems Highlights the autonomous functioning of the brain and body serotonin systems Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy

Download or read book The Serotonin Receptors written by Elaine Sanders-Bush and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors. Gaddum and Picarelli first sug gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist. The purpose of this book is to provide an up-to-date report on 5-HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT. For those of us who have been work ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

Download or read book Serotonin written by Bernard Haber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.

Download or read book 5 HT2C Receptors in the Pathophysiology of CNS Disease written by Giuseppe Di Giovanni and published by Springer Science & Business Media. This book was released on 2010-11-30 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.

Download or read book Receptor Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Download or read book Serotonin Receptor Technologies written by Wolfgang Blenau and published by Humana Press. This book was released on 2014-12-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting a vast amount of new information concerning the functional characteristics of the various 5-HT receptor subtypes and the Na+-dependent serotonin transporter (SERT), this volume provides state of the art methodologies currently applied in serotonin research from leading experts in the field. Serotonin Receptor Technologies describes approaches that vary from molecular biological and biochemical techniques (e.g., regarding receptor dimerization), fluorescence microscopy and imaging applications, flow cytometry, the use of organotypic slice and cell cultures to the generation of genetically modified animal models and the development of sophisticated behavioral tests, thus covering a wide spectrum of techniques to study serotonergic signaling in detail. Written for the popular Neuromethods series, chapters include the kind of detail and practical advice that ensures successful results in the lab. Authoritative and convenient, Serotonin Receptor Technologies serves to foster both basic and translational research aiming to further deepen our understanding of the various facets of aminergic systems, as well as to aid research on similar problems with related GPCRs and neurotransmitter transporters.