Download or read book Serotonin Receptors in Neurobiology written by Amitabha Chattopadhyay and published by CRC Press. This book was released on 2007-05-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l

Download or read book Handbook of the Behavioral Neurobiology of Serotonin written by Christian P. Muller and published by Academic Press. This book was released on 2009-12-30 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. - The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system - Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others - The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community - Of great value not only for researchers and experts, but also for students and clinicians as a background reference

Download or read book Serotonin Neurotransmitter and Hormone of Brain Bowels and Blood written by Kaneez Fatima-Shad and published by BoD – Books on Demand. This book was released on 2024-06-19 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin is an amazing neurotransmitter and hormone that is not only responsible for mood regulation but also plays an important role in regulating various aspects of human physiology and directly affecting human health. Serotonin is key to providing nutrition and oxygen from head to toe through vasoconstriction and hemostasis. The chapters in this book describe in detail not only how the serotonin receptor network interacts with each other but also their role in various pathologies. Disorders of serotonin could be related to structural and/or functional damage to the blood, brain, and bowel. Early identification of these conditions could benefit many diseases such as atherosclerosis, stroke, depression, and irritable bowel syndrome. The effects of serotonin abnormalities extend beyond one’s intellectual capacity. These effects can be felt at any time, from embryonic life to old age. In this book, you will not only find the role of other hormones such as insulin on serotonin but will also learn how serotonin plays an essential role in both plants and animals.

Download or read book Neurobiology of Body Fluid Homeostasis written by Laurival Antonio De Luca Jr. and published by CRC Press. This book was released on 2013-10-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.

Download or read book The Serotonin Receptors written by Elaine Sanders-Bush and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors. Gaddum and Picarelli first sug gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist. The purpose of this book is to provide an up-to-date report on 5-HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT. For those of us who have been work ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

Download or read book Serotonin Receptor Subtypes written by Stephen J. Peroutka and published by Wiley-Liss. This book was released on 1991 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative work explores the complex biochemical interactions of serotonin and related serotonergic agents with their receptors. It covers the molecular pharmacology of serotonin receptor subclasses, relating serotonin's influence on behavior, neuropsychiatric disease, and electrophysiology to characterizations at the molecular level.

Download or read book The Serotonin Receptors written by Bryan L. Roth and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Download or read book Serotoninergic Neurons and 5 HT Receptors in the CNS written by H.G. Baumgarten and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Download or read book Serotonin Receptors and their Ligands written by B. Olivier and published by Elsevier. This book was released on 1997-07-10 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters.The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account.The (potential) therapeutic applications of ligands of the different subtypes are described.Altogether an excellent addition to the Pharmacochemical Library series.

Download or read book Serotonin written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2017-07-26 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.

Download or read book Serotonin Molecular Biology Receptors and Functional Effects written by FOZARD and published by Birkhäuser. This book was released on 2012-12-06 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second IUPHAR Satellite Meeting on Serotonin was held under the auspices of the Serotonin Club in Basel, Switzerland in July 1990. The scope was wide, ranging from molecular biology through in vitro and in vivo pharmacology to new drug tools and their clinical signifi cance. There were three invited review lectures, by J. M. Palacios, D. I. Wallis and A. Kaumann, and S. Peroutka gave the first Serotonin Club Irvine H. Page Lecture. The rest of the oral programme was put together by the Scientific Organizing Committee based on volunteered research contributions. The invited review lecturers, the platform speak ers and selected poster contributors were invited to write up their contributions for inclusion in this volume. Most complied and this book is the result of their efforts. When instructing the authors prior to the meeting, we emphasized that selected new data should be put in the context of the literature findings. In this way we hoped to achieve topicality yet preserve the review perspective which facilitates its appreciation by the non-special ist. It was truly a pleasure to read the interesting papers which resulted and to prepare them for publication. We believe they convey to a remarkable degree the spirit of what was generally felt to be a highly stimulating exchange of information on matters serotonergic which took place in Basel last July.

Download or read book The Serotonin System written by Mark Tricklebank and published by Academic Press. This book was released on 2019-06-15 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Serotonin System: History, Neuropharmacology, and Pathology provides an up-to-date accounting on the physiology and pathophysiology of serotonin and the role it plays in behavioral functions. In addition, the book explores the potential roles of 5-HT1 in neurodevelopmental disorders and summarizes the history of the discovery and development of serotonergic drugs for the treatment of neuropsychiatric disorders. This concise, yet thorough, volume is the perfect introduction to this critical neurotransmitter. It is ideal for students and researchers new to the study of behavior, neuropsychiatry or neuropharmacology, but is also a great resource for established investigators who want a greater perspective on serotonin. Examines the role of serotonin in physiological functions and neuropsychiatric disorders Provides in-depth knowledge on all aspects of the serotonin system Explores serotonergic receptors as targets for both current and new therapeutic compounds

Download or read book Serotonin and Sleep Molecular Functional and Clinical Aspects written by Jaime M. Monti and published by Springer Science & Business Media. This book was released on 2008-03-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.

Download or read book Serotonin written by Bernard Haber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.

Download or read book Serotonin and Anxiety written by Caio Maximino and published by Springer Science & Business Media. This book was released on 2012-05-31 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system. In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure – the dorsal raphe nucleus – that structure is not homogeneous from anatomical, physiological and neurochemical points of view, nor are its projections to the cerebral aversive and behavioral inhibition systems. The diverse findings which compose this picture of complexity – whether they arise from developmental neurobiology, electrophysiology, neurochemistry, neuroendocrinology, neuropsychopharmacology or behavioral neuroscience – are integrated in this book. Advanced undergraduate, graduate students, and researchers will benefit from the information. The result sheds light on many important questions regarding the neuroanatomical, pharmacological and functional aspects of the role of serotonin in anxiety disorders, and points to future avenues of research.

Download or read book Receptors in the Human Nervous System written by F. A. O. Mendelsohn and published by Academic Press. This book was released on 2013-10-22 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.