Download or read book New Strategies Targeting Cancer Metabolism written by Galal H. Elgemeie and published by Elsevier. This book was released on 2022-05-17 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields. - Provides the only resource dedicated to synthetic strategies of antimetabolites - Features synthetic strategies for nucleosides and their analogues - Includes coverage of purine-, pyrimidine- and antifolate-based anticancer drugs - The most significant anticancer alkylating agents and natural products are demonstrated

Download or read book The British National Bibliography written by Arthur James Wells and published by . This book was released on 2001 with total page 1864 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index of Conference Proceedings written by British Library. Document Supply Centre and published by . This book was released on 2002 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis of Heterocycles via Multicomponent Reactions II written by Romano V. A. Orru and published by Springer. This book was released on 2010-07-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Download or read book Advances on Mechanics Design Engineering and Manufacturing II written by Francisco Cavas-Martínez and published by Springer. This book was released on 2019-04-27 with total page 833 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the papers presented at the International Joint Conference on Mechanics, Design Engineering and Advanced Manufacturing (JCM 2018), held on 20-22 June 2018 in Cartagena, Spain. It reports on cutting-edge topics in product design and manufacturing, such as industrial methods for integrated product and process design; innovative design; and computer-aided design. Further topics covered include virtual simulation and reverse engineering; additive manufacturing; product manufacturing; engineering methods in medicine and education; representation techniques; and nautical, aeronautics and aerospace design and modeling. The book is divided into six main sections, reflecting the focus and primary themes of the conference. The contributions presented here will not only provide researchers, engineers and experts in a range of industrial engineering subfields with extensive information to support their daily work; they are also intended to stimulate new research directions, advanced applications of the methods discussed, and future interdisciplinary collaborations.

Download or read book Sensor Technologies written by Michael J. McGrath and published by Apress. This book was released on 2014-01-23 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensor Technologies: Healthcare, Wellness and Environmental Applications explores the key aspects of sensor technologies, covering wired, wireless, and discrete sensors for the specific application domains of healthcare, wellness and environmental sensing. It discusses the social, regulatory, and design considerations specific to these domains. The book provides an application-based approach using real-world examples to illustrate the application of sensor technologies in a practical and experiential manner. The book guides the reader from the formulation of the research question, through the design and validation process, to the deployment and management phase of sensor applications. The processes and examples used in the book are primarily based on research carried out by Intel or joint academic research programs. “Sensor Technologies: Healthcare, Wellness and Environmental Applications provides an extensive overview of sensing technologies and their applications in healthcare, wellness, and environmental monitoring. From sensor hardware to system applications and case studies, this book gives readers an in-depth understanding of the technologies and how they can be applied. I would highly recommend it to students or researchers who are interested in wireless sensing technologies and the associated applications.” Dr. Benny Lo Lecturer, The Hamlyn Centre, Imperial College of London “This timely addition to the literature on sensors covers the broad complexity of sensing, sensor types, and the vast range of existing and emerging applications in a very clearly written and accessible manner. It is particularly good at capturing the exciting possibilities that will occur as sensor networks merge with cloud-based ‘big data’ analytics to provide a host of new applications that will impact directly on the individual in ways we cannot fully predict at present. It really brings this home through the use of carefully chosen case studies that bring the overwhelming concept of 'big data' down to the personal level of individual life and health.” Dermot Diamond Director, National Centre for Sensor Research, Principal Investigator, CLARITY Centre for Sensor Web Technologies, Dublin City University "Sensor Technologies: Healthcare, Wellness and Environmental Applications takes the reader on an end-to-end journey of sensor technologies, covering the fundamentals from an engineering perspective, introducing how the data gleaned can be both processed and visualized, in addition to offering exemplar case studies in a number of application domains. It is a must-read for those studying any undergraduate course that involves sensor technologies. It also provides a thorough foundation for those involved in the research and development of applied sensor systems. I highly recommend it to any engineer who wishes to broaden their knowledge in this area!" Chris Nugent Professor of Biomedical Engineering, University of Ulster

Download or read book Supramolecular Systems in Biomedical Fields written by Hans-Jorg Schneider and published by Royal Society of Chemistry. This book was released on 2013-09-06 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications. Supramolecular Systems for Biomedical Fields provides in sixteen chapters a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes. This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.

Download or read book Media Art written by Valentino Catricalà and published by . This book was released on 2015 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Shadowrun Cutting Aces written by Catalyst Game Labs and published by . This book was released on 2017-03-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hotel Bartender Who Slips You A Guests Room Number Because He Thinks It Will Help Him Get Lucky. The Security Guard Who Lets A Team Into A Top-Secret Facility Because He Thinks Hes Pitching In On Covert-Ops Training. The Business Suit Who Drops Ten Thousand Nuyen On A Project Because He Thinks Itll Earn Him Fifty Thousand. Marks, All Of Them, And The Sixth World Is Full Of Them. Yeah, Blasting Your Way Into A Well-Guarded Facility Is Fun, But Talking Your Way In, Smooth And Subtle, Might Be More Rewarding. Almost Every Kind Of Shadowrun Involves At Least A Little Con Artistry, And Some Of Them Are Full-On Long Cons. That Means You Need To Sharpen Your Con Game. With Tips, Plot Updates, Spells, Gear, And More To Improve Characters Con Abilities, Cutting Aces Gives Players The Swagger And Skills They Need To Swindle The World. It Also Includes Information On One Of The Sixth Worlds Hottest Spots For Running A Conistanbul, City Of The Worlds Desire. Cuttings Aces Is For Use With Shadowrun, Fifth Edition, And It Also Contains Plot Information, Story Ideas, And Characters That Can Be Used With Shadowrun: Anarchy With Slight Adjustments Of Character Stats.

Download or read book Photochemistry and Photophysics of Coordination Compounds II written by Vincenzo Balzani and published by Springer. This book was released on 2007-08-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photochemistry (a term that broadly speaking includes photophysics) is abranchofmodernsciencethatdealswiththeinteractionoflightwithmatter and lies at the crossroadsof chemistry, physics, and biology. However, before being a branch of modern science, photochemistry was (and still is today), an extremely important natural phenomenon. When God said: “Let there be light”, photochemistry began to operate, helping God to create the world as wenowknowit.Itislikelythatphotochemistrywasthesparkfortheoriginof life on Earth and played a fundamental role in the evolution of life. Through the photosynthetic process that takes place in green plants, photochemistry is responsible for the maintenance of all living organisms. In the geological past photochemistry caused the accumulation of the deposits of coal, oil, and naturalgasthat wenowuseasfuels.Photochemistryisinvolved inthecontrol ofozoneinthestratosphereandinagreatnumber ofenvironmentalprocesses thatoccurintheatmosphere,inthesea,andonthesoil.Photochemistryisthe essenceoftheprocessofvisionandcausesavarietyofbehavioralresponsesin living organisms. Photochemistry as a science is quite young; we only need to go back less than one century to ?nd its early pioneer [1]. The concept of coordination compound is also relatively young; it was established in 1892, when Alfred Werner conceived his theory of metal complexes [2]. Since then, the terms coordination compound and metal complex have been used as synonyms, even if in the last 30 years, coordination chemistry has extended its scope to the binding ofall kinds of substrates [3, 4].

Download or read book Springer Handbook of Science and Technology Indicators written by Wolfgang Glänzel and published by Springer Nature. This book was released on 2019-10-30 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook presents the state of the art of quantitative methods and models to understand and assess the science and technology system. Focusing on various aspects of the development and application of indicators derived from data on scholarly publications, patents and electronic communications, the individual chapters, written by leading experts, discuss theoretical and methodological issues, illustrate applications, highlight their policy context and relevance, and point to future research directions. A substantial portion of the book is dedicated to detailed descriptions and analyses of data sources, presenting both traditional and advanced approaches. It addresses the main bibliographic metrics and indexes, such as the journal impact factor and the h-index, as well as altmetric and webometric indicators and science mapping techniques on different levels of aggregation and in the context of their value for the assessment of research performance as well as their impact on research policy and society. It also presents and critically discusses various national research evaluation systems. Complementing the sections reflecting on the science system, the technology section includes multiple chapters that explain different aspects of patent statistics, patent classification and database search methods to retrieve patent-related information. In addition, it examines the relevance of trademarks and standards as additional technological indicators. The Springer Handbook of Science and Technology Indicators is an invaluable resource for practitioners, scientists and policy makers wanting a systematic and thorough analysis of the potential and limitations of the various approaches to assess research and research performance.

Download or read book Alien Bestiary 5E written by Jason Nelson and published by . This book was released on 2023-10-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It Came from the Stars!The Alien Bestiary brings you an incredible array of sci-fi and space-themed monsters and menaces for the 5th Edition of the world's most famous roleplaying game! The creatures you'll find within are perfect for whenever your heroes venture into the dark tapestry of space or have to defend their homeworld from alien invasion by eldritch horrors from beyond the stars, whether you use a universe of your own design, or a dedicated sci-fi saga like the Aethera Campaign Setting or the Legendary Planet Adventure Path for 5E! You'll find allies and adversaries within these pages, from playable races for your sci-fi game to cosmic horrors and apocalyptic enemies inspired by classic themes of science fiction. This volume collects nearly 300 monsters from Challenge 1/8 to 30, from mutant minions to cosmic abominations. You'll find residents of the Legendary Planet and Aethera settings, 5E aliens and androids like the myrmidon robot, plasma ooze, and star-spawn of Cthulhu, and brand-new never-before-seen monsters like the asteroid worm, star fairy, meteor dragon, and supermassive singularity! The Alien Bestiary is more than just monsters too, with appendices devoted to cults of the Great Old Ones, creatures of the Aethera system, creature indices by type and CR, high-tech traps and hazards, and spells, feats, and expanded rules for aetherite radiation, vacuum, and more! The PDF version, of course, is hyperlinked and bookmarked for your convenience, and the book is packed with incredible artwork and delightful design by some of the best authors in the business. These monsters are dynamic and cinematic in how they play at the table, with ecology, history, and lore that are a pleasure to read. Don't let your 5th Edition campaign get lost in space or just be a trek among the stars! Grab a copy of this incredible 424-page monster accessory today and Make Your Game Legendary!

Download or read book ISO 26000 A Standardized View on Corporate Social Responsibility written by Samuel O. Idowu and published by Springer. This book was released on 2018-08-03 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and detailed introduction to the ISO 26000 standard for social responsibility (SR) in businesses and corporations. In addition to discussing the standard’s focus on various stakeholders and seven core topics, the book underscores its key aspects and most debatable issues, with a focus on its connection to sustainable business practices. It presents numerous cases and practical examples of the ISO 26000’s implementation and discusses the outcomes and lessons learned, in terms of the extent to which organizations can envision practicing CSR in ways that fit their activities, stakeholders and environment. Lately, the ISO 26000 has proved to offer an interesting and important approach to the standardization of (corporate) social responsibility. Approached and perceived as a voluntary standard that does not include any specific requirements, determining the best way to implement and work with it involved a considerable amount of experimentation. This book showcases the current state of application and discusses how different countries have developed their own specific versions of the standard, which organizations can use to certify their SR processes.

Download or read book Remote Sensing Platforms written by Alden P. Colvocoresses and published by . This book was released on 1974 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Satellite Soil Moisture Retrieval written by Prashant K. Srivastava and published by Elsevier. This book was released on 2016-04-29 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Satellite Soil Moisture Retrieval: Techniques and Applications offers readers a better understanding of the scientific underpinnings, development, and application of soil moisture retrieval techniques and their applications for environmental modeling and management, bringing together a collection of recent developments and rigorous applications of soil moisture retrieval techniques from optical and infrared datasets, such as the universal triangle method, vegetation indices based approaches, empirical models, and microwave techniques, particularly by utilizing earth observation datasets such as IRS III, MODIS, Landsat7, Landsat8, SMOS, AMSR-e, AMSR2 and the upcoming SMAP. Through its coverage of a wide variety of soil moisture retrieval applications, including drought, flood, irrigation scheduling, weather forecasting, climate change, precipitation forecasting, and several others, this is the first book to promote synergistic and multidisciplinary activities among scientists and users working in the hydrometeorological sciences. - Demystifies soil moisture retrieval and prediction - Links soil moisture retrieval techniques with new satellite missions for earth and environmental science oriented problems - Written to be accessible to a wider range of professionals with a common interest in geo-spatial techniques, remote sensing, sustainable water resource development, and earth and environmental issues

Download or read book Nucleic Acids Chemistry written by Ramon Eritja and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-01-18 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Download or read book Germanium written by Regina V. Germanno and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Germanium is an important semiconductor material used in transistors and various other electronic devices. Its major end uses are fibre-optic systems and infrared optics, but it is also used for polymerisation catalysts, as well as in electronics and solar cell applications. This book presents current research in the study of germanium, including properties and generation by irradiation of germanium point defects in Ge-doped silica; Germanium encaged fullerene-synthesis; research of silicon and germanium structures with films of oxides and fluoride rare earth elements and new generation germanium detectors for double beta decay searches.