Download or read book Neuropilin written by Dominique Bagnard and published by Springer Science & Business Media. This book was released on 2011-04-27 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica tion of several families of adhesion molecules, well conserved throughout evolu tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi gration, or differentiation depends on both cell surface adhesion properties and acti vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.
Download or read book Semaphorins Receptor and Intracellular Signaling Mechanisms written by Gerard Pasterkamp and published by Springer Science & Business Media. This book was released on 2007-12-05 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. It covers the entire semaphorin field from neurosciences to cardiovascular research and beyond, detailing all the latest techniques and results. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.
Download or read book Semaphorins written by Atsushi Kumanogoh and published by Springer. This book was released on 2015-05-07 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders. Based on this current research background, the book covers the essential state-of-the-art findings for basic scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, as well as for physicians in neurology, cardiology, oncology, orthopedic surgery, otorhinolaryngology, ophthalmology, allergology, and rheumatology.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Download or read book Semaphorins Receptor and Intracellular Signaling Mechanisms written by Gerard Pasterkamp and published by Springer. This book was released on 2007-06-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. It covers the entire semaphorin field from neurosciences to cardiovascular research and beyond, detailing all the latest techniques and results. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.
Download or read book Fundamental Neuroscience written by Larry Squire and published by Elsevier. This book was released on 2002-11-19 with total page 1447 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates.The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.Key Features* Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters* Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts* Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM
Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Download or read book Kidney Development Disease Repair and Regeneration written by Melissa Helen Little and published by Academic Press. This book was released on 2015-08-06 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
Download or read book Textbook of Aging Skin written by Miranda A. Farage and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.
Download or read book Engineered Targeted Cancer Immunotherapies written by Massimo Fantini and published by Frontiers Media SA. This book was released on 2022-08-01 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Intercellular Signaling in Development and Disease written by Edward A. Dennis and published by Academic Press. This book was released on 2011-04-05 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations intranscription factors that provide new targets for treating disease. - Articles written and edited by experts in the field - Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease - Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
Download or read book Guidance Molecules in Cancer and Tumor Angiogenesis written by Ira Daar and published by Academic Press. This book was released on 2012-05-29 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Guidance molecules in Cancer and cancer angiogenesis". With outstanding and original reviews, this volume covers topics such as Guidance for life, death and neoplasia by netrin receptors, Semaphorin signals tweaking the tumor microenvironment, NOTCH Activation in Human Malignancy, and Essential roles of EphrinB in endothelial cell function and angiogenesis.
Download or read book Targeting Angiogenesis to Treat Autoimmune Diseases and Cancer written by Michal Amit Rahat and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neuropilins Role and Function in Health and Disease written by Gera Neufeld and published by Springer. This book was released on 2017-02-06 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.
Download or read book Tumor Angiogenesis written by Dieter Marmé and published by Springer Science & Business Media. This book was released on 2007-12-05 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.
Download or read book Advances in Immunology written by and published by Elsevier. This book was released on 2003-12-18 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries. - Edited by a new editor, Frederick W. Alt - Covers molecular mechanisms of host-pathogen interaction - Discusses prions and the immune system
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2011-10-14 with total page 4071 pages. Available in PDF, EPUB and Kindle. Book excerpt: The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in 7 Volumes with an A-Z format of approx. 7000 entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public.
